PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma.

Epigenome modifications and genomic instability in normal and malignant B cells

Haas M, Caron G, Chatonnet F, Manenti S, Alaterre E, Devin J, Delaloy C, Bertolin G, Viel R, Pignarre A, Llamas-Gutierrez F, Marchalot A, Decaux O, Tarte K, Delpy L, Moreaux J, Fest T

SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers.

Chromatin and cell biology

Barral A, Pozo G, Ducrot L, Papadopoulos GL, Sauzet S, Oldfield AJ, Cavalli G, Déjardin J

Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice

Meiosis and recombination

Ihsan Dereli, Marcello Stanzione, Fabrizio Olmeda, Frantzeskos Papanikos, Marek Baumann, Sevgican Demir, Fabrizia Carofiglio, Julian Lange, Bernard de Massy, Willy M Baarends, James Turner, Steffen Rulands, Attila Tóth

Mechanisms of Polycomb group protein function in cancer.

Chromatin and cell biology

Parreno V, Martinez AM, Cavalli G

Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.

mRNA Regulation and Development

Ribot C, Soler C, Chartier A, Al Hayek S, Naït-Saîdi R, Barbezier N, Coux O, Simonelig M

Molecular mechanisms of transgenerational epigenetic inheritance.

Chromatin and cell biology

Fitz-James MH, Cavalli G

STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

Molecular Basis of Inflammation

Isabelle K.Vila, Hanane Chamma, Alizée Steer, Mathilde Saccas, Clara Taffoni, Evgenia Turtoi, Line S.Reinert, Saqib Hussain, Johanna Marines, Lei Jin, Xavier Bonnefont, Mathieu Hubert, Olivier Schwartz, Soren R.Paludan, Gaetan Van Simaeys, Gilles Doumont, Bijan Sobhian, Dimitrios Vlachakis, Andrei Turtoi, Nadine Laguette


Angiogenic factors could help us to define patients obtaining complete response with undetectable minimal residual disease in untreated CLL patients treated by FCR: results from the CLL2010FMP, a FILO study.

Epigenome modifications and genomic instability in normal and malignant B cells

Gagez AL, Paul F, Alaterre E, Gouilleux-Gruart V, Tuaillon E, Lepretre S, Ternant D, Letestu R, Moreaux J, Cartron G

Studying the DNA damage response in embryonic systems.

Genome Surveillance and Stability

Lo Furno E, Recolin B, van der Laan S, Aze A, Maiorano D

Editorial: Nucleic Acid-Associated Inflammation.

Molecular Basis of Inflammation

Laguette N, Langevin C, Olagnier D, Torraca V, Vanpouille-Box C, Verrier ER.

A regulatory phosphorylation site on Mec1 controls chromatin occupancy of RNA polymerases during replication stress.

Maintenance of genome integrity during DNA replication

Hurst V, Challa K, Jonas F, Forey R, Sack R, Seebacher J, Schmid CD, Barkai N, Shimada K, Gasser SM, Poli J

Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma.

Epigenome modifications and genomic instability in normal and malignant B cells

Herviou L, Ovejero S, Izard F, Karmous-Gadacha O, Gourzones C, Bellanger C, De Smedt E, Ma A, Vincent L, Cartron G, Jin J, De Bruyne E, Grimaud C, Julien E, Moreaux J