PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma.
Published the 03/02/2022
- Blood
- pmid : 35108359
Epigenome modifications and genomic instability in normal and malignant B cells
Haas M, Caron G, Chatonnet F, Manenti S, Alaterre E, Devin J, Delaloy C, Bertolin G, Viel R, Pignarre A, Llamas-Gutierrez F, Marchalot A, Decaux O, Tarte K, Delpy L, Moreaux J, Fest T
Devin J, Caneque T, Lin YL, Mondoulet L, Veyrune JL, Abouladze M, Garcia De Paco E, Karmous Gadacha O, Cartron G, Pasero P, Bret C, Rodriguez R, Moreaux J
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SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers.
Published the 27/01/2022
- Mol Cell
- pmid : 35081363
Chromatin and cell biology
Barral A, Pozo G, Ducrot L, Papadopoulos GL, Sauzet S, Oldfield AJ, Cavalli G, Déjardin J
Published the 26/01/2022
- BioRxiv
Gene regulation
Giuseppa Grasso, Charbel Akkawi, Celine Franckhauser, Rima Nait-Saidi, Maxime Bello, Jérôme Barbier, Rosemary Kiernan
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Published the 25/01/2022
- Nucleic Acids Research
Genome Surveillance and Stability
Lo Furno E., Busseau, I., Aze, A., Lorenzi, C., Saghira, C., Danzi, M., Zuchner, S., Maiorano, D.
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Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice
Published the 22/01/2022
- Nucleic Acid Research
Meiosis and recombination
Ihsan Dereli, Marcello Stanzione, Fabrizio Olmeda, Frantzeskos Papanikos, Marek Baumann, Sevgican Demir, Fabrizia Carofiglio, Julian Lange, Bernard de Massy, Willy M Baarends, James Turner, Steffen Rulands, Attila Tóth
Mechanisms of Polycomb group protein function in cancer.
Published the 21/01/2022
- Cell Res
- pmid : 35046519
Chromatin and cell biology
Parreno V, Martinez AM, Cavalli G
Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.
Published the 14/01/2022
- PLoS Genet
- pmid : 35025870
mRNA Regulation and Development
Ribot C, Soler C, Chartier A, Al Hayek S, Naït-Saîdi R, Barbezier N, Coux O, Simonelig M
Published the 04/01/2022
- Cell Metabolism
Molecular Basis of Inflammation
Isabelle K.Vila, Hanane Chamma, Alizée Steer, Mathilde Saccas, Clara Taffoni, Evgenia Turtoi, Line S.Reinert, Saqib Hussain, Johanna Marines, Lei Jin, Xavier Bonnefont, Mathieu Hubert, Olivier Schwartz, Soren R.Paludan, Gaetan Van Simaeys, Gilles Doumont, Bijan Sobhian, Dimitrios Vlachakis, Andrei Turtoi, Nadine Laguette
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Angiogenic factors could help us to define patients obtaining complete response with undetectable minimal residual disease in untreated CLL patients treated by FCR: results from the CLL2010FMP, a FILO study.
Published the 23/11/2021
- Leuk Lymphoma
- pmid : 34806520
Epigenome modifications and genomic instability in normal and malignant B cells
Gagez AL, Paul F, Alaterre E, Gouilleux-Gruart V, Tuaillon E, Lepretre S, Ternant D, Letestu R, Moreaux J, Cartron G
Studying the DNA damage response in embryonic systems.
Published the 16/11/2021
- Methods Enzymol
- pmid : 34776225
Genome Surveillance and Stability
Lo Furno E, Recolin B, van der Laan S, Aze A, Maiorano D
Editorial: Nucleic Acid-Associated Inflammation.
Published the 27/10/2021
-
- pmid : 34777401
Molecular Basis of Inflammation
Laguette N, Langevin C, Olagnier D, Torraca V, Vanpouille-Box C, Verrier ER.
RNA-Sequencing-Based Transcriptomic Score with Prognostic and Theranostic Values in Multiple Myeloma.
Published the 24/10/2021
- J Pers Med
- pmid : 34683129
Epigenome modifications and genomic instability in normal and malignant B cells
Alaterre E, Vikova V, Kassambara A, Bruyer A, Robert N, Requirand G, Bret C, Herbaux C, Vincent L, Cartron G, Elemento O, Moreaux J
A regulatory phosphorylation site on Mec1 controls chromatin occupancy of RNA polymerases during replication stress.
Published the 28/09/2021
- EMBO J
- pmid : 34569643
Maintenance of genome integrity during DNA replication
Hurst V, Challa K, Jonas F, Forey R, Sack R, Seebacher J, Schmid CD, Barkai N, Shimada K, Gasser SM, Poli J
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma.
Published the 18/09/2021
- Clin Epigenetics
- pmid : 34530900
Epigenome modifications and genomic instability in normal and malignant B cells
Herviou L, Ovejero S, Izard F, Karmous-Gadacha O, Gourzones C, Bellanger C, De Smedt E, Ma A, Vincent L, Cartron G, Jin J, De Bruyne E, Grimaud C, Julien E, Moreaux J