Neurogenetics and memory

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Drosophila adult brain developmental molecular genetics

Drosophila adult brain developmental molecular genetics is a youg science which is gaining momentum. We can raisonably foresee that the gene cascades at work during brain development will be conserved in mammals.

In Drosophila, recent techniques are now available and allow to work efficiently on this topic.

Mushroom bodies (MB) may be considered as the mamalian hippocampus analogue are an excellent model in order to study brain development. Each MB neuroblast generates, in a sequential fashion, three distinct classes of neurons.
First the γ then the α'β' and finally the αβ neurons appear during development.

MB are essential for several forms of learning and memory.

We have introduced in the laboratory a memory paradigm based on male courtship behavior (in collaboration with M.L. Parmentier and Y. Grau, IGF).
Therefore we are able to correlate a developing brain structure and its fonction.

Jean-Maurice DURA
Researcher
0434359960

Charline GAL
PhD Student
0434359960

Ana BOULANGER
ITA
0434359960

Clarisse PERRON
ITA
0434359960

Publications of the team

Chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms

Published the 01/10/2023 - Development , Research article 37767633

Clarisse Perron, Pascal Carme, Arnau Llobet Rosell, Eva Minnaert, Salomé Ruiz Demoulin, Héloïse Szczkowski, Lukas Jakob Neukomm, Jean-Maurice Dura and Ana Boulanger

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The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons.

Published the 05/06/2023 - Proc Natl Acad Sci U S A , 120(24):e2303392120 37276397

Ji H, Wang B, Shen Y, Labib D, Lei J, Chen X, Sapar M, Boulanger A, Dura JM, Han C

Orion et le dialogue neurone-glie au cours du remodelage neuronal

Published the 21/04/2022 - La lettre des Neurosciences n°62 page 29-32

Ana Boulanger et Jean-Maurice Dura

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Neuron-glia crosstalk in neuronal remodeling and degeneration: Neuronal signals inducing glial cell phagocytic transformation in Drosophila

Published the 07/03/2022 - BioEssays

Ana Boulanger, Jean-Maurice Dura

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Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling

Published the 23/03/2021 - Nature Communications

Ana Boulanger, Camille Thinat, Stephan Züchner, Lee G. Fradkin, Hugues Lortat-Jacob, Jean-Maurice Dura

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Htt is a repressor of Abl activity required for APP-induced axonal growth

Published the 19/01/2021 - PLOS GENETICS

Claire Marquilly,Germain U. Busto,Brittany S. Leger,Ana Boulanger,Edward Giniger,James A. Walker,Lee G. Fradkin,Jean-Maurice Dura

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Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors

Published the 01/01/2015 - Cell Rep , 11(8):1293-304 25981040

Reynaud E, Lahaye LL, Boulanger A, Petrova IM, Marquilly C, Flandre A, Martianez T, Privat M, Noordermeer JN, Fradkin LG, Dura JM

Nuclear receptors and Drosophila neuronal remodelling

Published the 01/01/2015 - Biochim Biophys Acta , 1849(2):187-195 24882358

Boulanger A, Dura JM.

Ecdysone signaling at metamorphosis triggers apoptosis of Drosophila abdominal muscles

Published the 01/01/2013 - Dev Biol. , 383, 2, 375-384 24051228

Zirin J, Cheng D, Dhanyasi N, Cho J, Dura JM, Vijayraghavan K, Perrimon N.

The Drosophila Amyloid Precusor Protein is a conserved neuronal modulator of Wnt PCP signaling

Published the 01/01/2013 - PLoS Biology , 11(5):e1001562 23690751

Soldano A., Okray Z., Janovska P., Tmejova K., Reynaud E., Claeys A., Yan J., Atak Z. K., De Strooper B., Dura J.-M., Bryja V., Hasssan B. A.

Drosophila Motor Neuron Retraction during Metamorphosis Is Mediated by Inputs from TGF-β/BMP Signaling and Orphan Nuclear Receptors

Published the 01/01/2012 - PLoS One , 7(7):e40255 22792255

Boulanger A, Farge M, Ramanoudjame C, Wharton K, Dura JM

Mushroom body neuronal remodelling is necessary for short-term but not for long-term courtship memory in Drosophila

Published the 01/01/2012 - Eur J Neurosci. , 35, 11, 1684-1691. doi: 10.1111/j.1460-9568.2012.08103.x. 22571719

Redt-Clouet C, Trannoy S, Boulanger A, Tokmatcheva E, Savvateeva-Popova E, Parmentier ML, Preat T, Dura JM

Parallel processing of appetitive short- and long-term memories in Drosophila.

Published the 01/01/2011 - Curr Biol. , 21(19):1647-53 21962716

Trannoy S, Redt-Clouet C, Dura JM, Preat T.

ftz-f1 and Hr39 opposing roles on EcR expression during Drosophila mushroom body neuron remodeling

Published the 01/01/2011 - Nature Neuroscience , 14(1) : 37-44. voir Nature Neuroscience News and Views, Vol. 14 N°1 21131955

Boulanger, A., Clouet-Redt, C., Farge, M., Flandre, A., Guignard, T., Fernando, C., Juge, F. & Dura, JM.

Ryks: new partners for Wnts in the developing and regenerating nervous system

Published the 01/01/2010 - Trends Neurosci , 33,2,84-92

Fradkin, LG., Dura, JM., Noordermeer, JN

Respective roles of the DRL receptor and its ligand WNT5 in Drosophila mushroom body development.

Published the 01/01/2007 - Development , 134, 17, 3089-3097 17652353

Grillenzoni, N., Flandre, A., Lasbleiz, C., Dura, JM

In vivo evidence for a regulatory role of the kinase activity of the linotte/derailed receptor tyrosine kinase : a Drosophila Ryk ortholog

Published the 01/01/2005 - Development Genes and Evolution , 215(3):158-63

Taillebourg E., Moreau-Fauvarque C., Delaval K. and Dura J.-M.

Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila

Published the 01/01/2004 - Molecular Genetics and Genomics , 272:156-161

Perrin L. and Dura J.-M.

Identification and characterization of polyhomeotic PREs and TREs.

Published the 23/09/2003 - Dev Biol , 261(2):426-42 14499651

Bloyer S, Cavalli G, Brock HW, Dura JM

Genome wide prediction of Polycomb/trithorax Response Elements in Drosophila melanogaster.

Published the 01/01/2003 - Developmental Cell , 5, 759-771.

Ringrose L., Rehmsmeier M., Dura J.-M. and Paro R.

A gain of function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development.

Published the 01/01/2003 - Journal of Neurobiology , 57 (3), 291-302

Nicolaï M., Lasbleiz C. and Dura J.-M.

The leucine zipper motif of the Drosophila AF10 homolog can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.

Published the 01/01/2003 - Molecular and Cellular Biology , 23:119-130.

Perrin L., Bloyer S., Ferraz C., Agrawal N., Sinha P., and Dura J.-M.

Mutation of linotte causes behavioral defects independently of pigeon in Drosophila.

Published the 01/01/2002 - Neuroreport , 13:2309-2312.

Moreau-Fauvarque C., Taillebourg E., Préat T. and Dura J.-M.

Dominant modifiers of the polyhomeotic extra-sex-combs phenotype induced by marked P element insertional mutagenesis in Drosophila

Published the 01/01/2001 - Genetical Research , 78:137-148.

Fauvarque M.-O., Laurenti P., Boivin A., Bloyer S., Griffin-Shea R., Bourbon H.-M. and Dura J.-M.

P element replacement at the linotte/derailed locus in Drosophila: presence of the wild-type region in the homologous chromosome increases the efficiency.

Published the 01/01/2000 - Drosophila Information Service , 83:91-93

Taillebourg E. and Dura J.-M.

A novel mechanism for P element homing in drosophila.

Published the 01/01/1999 - Proc. Natl. Acad. Sci. USA , 96, 6856-6861.

Taillebourg, E. and Dura, J.M.

One-to-one correspondence between the two genetic units and the tandemly duplicated transcriptional units of the polyhomeotic locus of Drosphila.

Published the 01/01/1999 - Mol. Gen. Genet. , 261, 196-200.

Boivin, A., Fauvarque, M.O. and Dura, J.M.

White+ transgenes insertions presenting a dorso-ventral pattern define a single cluster of homeobox-genes that is silenced by the Polycomb-group proteins in Drosophila melanogaster.

Published the 01/01/1998 - Genetics , 149, 257-275.

Netter, S., Fauvarque, M.O., Diez del Corral, R., Dura, J.M. and Coen, D.

The receptor tyrosine kinase gene linotte is required for neuronal pathway selection in the Drosophila mushroom bodies.

Published the 01/01/1998 - Mechanisms of Development , 78, 47-61.

Moreau, C., Taillebourg, E., Boissoneau, E., Mesnard, J. and Dura, J.M.

In vivo chromatin accessibility correlates with gene silencing in Drosophila.

Published the 01/01/1998 - Genetics , 150, 1539-1549.

Boivin, A. and Dura, J.M.

Thèses et hdr

Role of APPL protein in axonal growth of pedunculated bodies in Drosophila melanogaster 25/09/2017

Defended by Claire Marquilly on 25-09-2017

Neurogenetics and memory

Drosophila adult brain developmental molecular genetics

Publications of the team

Chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms

The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons.

Orion et le dialogue neurone-glie au cours du remodelage neuronal

Neuron-glia crosstalk in neuronal remodeling and degeneration: Neuronal signals inducing glial cell phagocytic transformation in Drosophila

Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling

Htt is a repressor of Abl activity required for APP-induced axonal growth

Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors

Nuclear receptors and Drosophila neuronal remodelling

Ecdysone signaling at metamorphosis triggers apoptosis of Drosophila abdominal muscles

The Drosophila Amyloid Precusor Protein is a conserved neuronal modulator of Wnt PCP signaling

Drosophila Motor Neuron Retraction during Metamorphosis Is Mediated by Inputs from TGF-β/BMP Signaling and Orphan Nuclear Receptors

Mushroom body neuronal remodelling is necessary for short-term but not for long-term courtship memory in Drosophila

Parallel processing of appetitive short- and long-term memories in Drosophila.

ftz-f1 and Hr39 opposing roles on EcR expression during Drosophila mushroom body neuron remodeling

Ryks: new partners for Wnts in the developing and regenerating nervous system

Respective roles of the DRL receptor and its ligand WNT5 in Drosophila mushroom body development.

In vivo evidence for a regulatory role of the kinase activity of the linotte/derailed receptor tyrosine kinase : a Drosophila Ryk ortholog

Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila

Identification and characterization of polyhomeotic PREs and TREs.

Genome wide prediction of Polycomb/trithorax Response Elements in Drosophila melanogaster.

A gain of function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development.

The leucine zipper motif of the Drosophila AF10 homolog can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.

Mutation of linotte causes behavioral defects independently of pigeon in Drosophila.

Dominant modifiers of the polyhomeotic extra-sex-combs phenotype induced by marked P element insertional mutagenesis in Drosophila

P element replacement at the linotte/derailed locus in Drosophila: presence of the wild-type region in the homologous chromosome increases the efficiency.

A novel mechanism for P element homing in drosophila.

One-to-one correspondence between the two genetic units and the tandemly duplicated transcriptional units of the polyhomeotic locus of Drosphila.

White+ transgenes insertions presenting a dorso-ventral pattern define a single cluster of homeobox-genes that is silenced by the Polycomb-group proteins in Drosophila melanogaster.

The receptor tyrosine kinase gene linotte is required for neuronal pathway selection in the Drosophila mushroom bodies.

In vivo chromatin accessibility correlates with gene silencing in Drosophila.

Thèses et hdr

Role of APPL protein in axonal growth of pedunculated bodies in Drosophila melanogaster 25/09/2017

Head : Jean-Maurice DURA

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