Neurogenetics and memory

Genetics, cell biology and development

Drosophila adult brain developmental molecular genetics

Drosophila adult brain developmental molecular genetics is a youg science which is gaining momentum. We can raisonably foresee that the gene cascades at work during brain development will be conserved in mammals.

In Drosophila, recent techniques are now available and allow to work efficiently on this topic.

Mushroom bodies (MB) may be considered as the mamalian hippocampus analogue are an excellent model in order to study brain development. Each MB neuroblast generates, in a sequential fashion, three distinct classes of neurons.
First the γ then the α'β' and finally the αβ neurons appear during development.

MB are essential for several forms of learning and memory.

We have introduced in the laboratory a memory paradigm based on male courtship behavior (in collaboration with M.L. Parmentier and Y. Grau, IGF).
Therefore we are able to correlate a developing brain structure and its fonction.

PUBLICATIONS OF THE TEAM

Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling

Ana Boulanger, Camille Thinat, Stephan Züchner, Lee G. Fradkin, Hugues Lortat-Jacob & Jean-Maurice Dura

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Htt is a repressor of Abl activity required for APP-induced axonal growth

Claire Marquilly,Germain U. Busto,Brittany S. Leger,Ana Boulanger,Edward Giniger,James A. Walker,Lee G. Fradkin,Jean-Maurice Dura

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Nuclear receptors and Drosophila neuronal remodelling

Boulanger A, Dura JM.

Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors

Reynaud E, Lahaye LL, Boulanger A, Petrova IM, Marquilly C, Flandre A, Martianez T, Privat M, Noordermeer JN, Fradkin LG, Dura JM

The Drosophila Amyloid Precusor Protein is a conserved neuronal modulator of Wnt PCP signaling

Soldano A., Okray Z., Janovska P., Tmejova K., Reynaud E., Claeys A., Yan J., Atak Z. K., De Strooper B., Dura J.-M., Bryja V., Hasssan B. A.

Ecdysone signaling at metamorphosis triggers apoptosis of Drosophila abdominal muscles

Zirin J, Cheng D, Dhanyasi N, Cho J, Dura JM, Vijayraghavan K, Perrimon N.

Mushroom body neuronal remodelling is necessary for short-term but not for long-term courtship memory in Drosophila

Redt-Clouet C, Trannoy S, Boulanger A, Tokmatcheva E, Savvateeva-Popova E, Parmentier ML, Preat T, Dura JM

Drosophila Motor Neuron Retraction during Metamorphosis Is Mediated by Inputs from TGF-β/BMP Signaling and Orphan Nuclear Receptors

Boulanger A, Farge M, Ramanoudjame C, Wharton K, Dura JM

ftz-f1 and Hr39 opposing roles on EcR expression during Drosophila mushroom body neuron remodeling

Boulanger, A., Clouet-Redt, C., Farge, M., Flandre, A., Guignard, T., Fernando, C., Juge, F. & Dura, JM.

Parallel processing of appetitive short- and long-term memories in Drosophila.

Trannoy S, Redt-Clouet C, Dura JM, Preat T.

Ryks: new partners for Wnts in the developing and regenerating nervous system

Fradkin, LG., Dura, JM., Noordermeer, JN

Respective roles of the DRL receptor and its ligand WNT5 in Drosophila mushroom body development.

Grillenzoni, N., Flandre, A., Lasbleiz, C., Dura, JM

In vivo evidence for a regulatory role of the kinase activity of the linotte/derailed receptor tyrosine kinase : a Drosophila Ryk ortholog

Taillebourg E., Moreau-Fauvarque C., Delaval K. and Dura J.-M.

Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila

Perrin L. and Dura J.-M.

Identification and characterization of polyhomeotic PREs and TREs.

Bloyer S, Cavalli G, Brock HW, Dura JM

The leucine zipper motif of the Drosophila AF10 homolog can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.

Perrin L., Bloyer S., Ferraz C., Agrawal N., Sinha P., and Dura J.-M.

A gain of function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development.

Nicolaï M., Lasbleiz C. and Dura J.-M.

Genome wide prediction of Polycomb/trithorax Response Elements in Drosophila melanogaster.

Ringrose L., Rehmsmeier M., Dura J.-M. and Paro R.

Mutation of linotte causes behavioral defects independently of pigeon in Drosophila.

Moreau-Fauvarque C., Taillebourg E., Préat T. and Dura J.-M.

Dominant modifiers of the polyhomeotic extra-sex-combs phenotype induced by marked P element insertional mutagenesis in Drosophila

Fauvarque M.-O., Laurenti P., Boivin A., Bloyer S., Griffin-Shea R., Bourbon H.-M. and Dura J.-M.

P element replacement at the linotte/derailed locus in Drosophila: presence of the wild-type region in the homologous chromosome increases the efficiency.

Taillebourg E. and Dura J.-M.

One-to-one correspondence between the two genetic units and the tandemly duplicated transcriptional units of the polyhomeotic locus of Drosphila.

Boivin, A., Fauvarque, M.O. and Dura, J.M.

A novel mechanism for P element homing in drosophila.

Taillebourg, E. and Dura, J.M.

In vivo chromatin accessibility correlates with gene silencing in Drosophila.

Boivin, A. and Dura, J.M.

The receptor tyrosine kinase gene linotte is required for neuronal pathway selection in the Drosophila mushroom bodies.

Moreau, C., Taillebourg, E., Boissoneau, E., Mesnard, J. and Dura, J.M.

White+ transgenes insertions presenting a dorso-ventral pattern define a single cluster of homeobox-genes that is silenced by the Polycomb-group proteins in Drosophila melanogaster.

Netter, S., Fauvarque, M.O., Diez del Corral, R., Dura, J.M. and Coen, D.

MARQUILLY Claire
MARQUILLY Claire

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SARNELLI Clara
SARNELLI Clara

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RAMANOUDJAME Christophe
RAMANOUDJAME Christophe

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CABROL Christelle
CABROL Christelle

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CLOUET Christelle
CLOUET Christelle

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KRAFT Karoline
KRAFT Karoline

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LASBLEIZ Christelle
LASBLEIZ Christelle

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MARTIN Sabrina
MARTIN Sabrina

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NELY Julie
NELY Julie

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NICOLAI Maryse
NICOLAI Maryse

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PERRIN Laurent
PERRIN Laurent
LGPD/IBDM - Faculte des Sciences de Luminy - 13288 Marseille Cedex 09

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SALEMBIER Femke
SALEMBIER Femke

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TAILLEBOURG Emmanuel
TAILLEBOURG Emmanuel
DRDC/CEA-Grenoble

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THOMAS Jean-louis
THOMAS Jean-louis

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BABLED Amelie
BABLED Amelie
Promega

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REYNAUD Elodie
REYNAUD Elodie

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MOUSSA Salim
MOUSSA Salim

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FARGE Morgane
FARGE Morgane

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WHARTON Kristi
WHARTON Kristi
Brown University, Providence, RI 02912, USA

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CADILHAC Christelle
CADILHAC Christelle

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RUIZ Salome
RUIZ Salome

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Topic: Neuron-glia cross talk during axon degneration