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Evolution and function of molecular scissors: topoisomerases and meiosis
During meiosis, numerous exchanges between maternal and paternal chromosomes occur. These recombination events proceed by a mechanism of DNA breakage and repair during the prophase of the first division of meiosis.
These breaks are produced by enzymes related to topoisomerases.
In two studies published in Molecular Biology and Evolution and Nature communications, scientists have contributed to understand how this activity has specialized during evolution to become involved in sexual reproduction...
The Y chromosome has been degenerating for thousands of years and has already disappeared in some species. Could it disappear in humans? If so, would this mark the end of Homo sapiens?
"Y chromosome: towards the end of the male?" Podcast Radio France : La Science, CQFD
With
- Bernard de Massy Agricultural engineer and doctor in microbiology, specialist in molecular genetics Institute of Human Genetics, team Meiosis and recombination
- William Rowe-Pirra Freelance journalist for Sciences et Avenir andPour...
Born in Algiers in July 1939, Jacques Demaille was one of the fathers of the French genome program. As a physician and researcher, he left his mark on medical research in Montpellier. After a stay in the United States in the laboratory of Edmond H. Fischer's laboratory in the United States, where he won the Nobel Prize in Physiology in 1992, he directed the Centre de Recherche en Biochimie Macromoléculaire (CRBM) from 1983 to 1997 and founded the Institut de Génétique Humaine (IGH) in 1998, which...
