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embryogenèse précoce
Genome Surveillance and StabilityEarly embryos show signs of genomic instability as well as the presence of mutations whose origin was unknown until now.
In this article, published in the journal Nucleic Acids Research, scientists were able to identify a molecular mechanism responsible, and showed that it is the DNA damage tolerance system, which could also contribute to variations in genetic background between individuals.
The "3D Organization of our Genome” video
Chromatin and cell biologyA video illustrating the organization of the genome in 3D has been released by the Cavalli team. The video summarizes the current understanding of genome organization in the three-dimensional space of the cell nucleus. It illustrates the different layers of chromosome organization, from nucleosomes, which envelop 146 base pairs of DNA, to chromosome territories, which can contain hundreds of millions of base pairs of DNA sequence. Between these two extremes, the hierarchical folding of the chromatin fiber into "nucleosome clusters", "chromatin nanodomains or CNDs", "Topologically Associating Domains or TADs" (including their formation mechanism via loop-extrusion) and "Compartments A and B" are presented.
In the description of the video, references can be found that complete the content.
Team website page >>
Thanks to :
Fred Bantignies, IGH, CNRS et Univ. de Montpellier, France
Quentin Szabo, Dept Mol Life Sciences, University of Zürich, Suisse
and also :
Arkitek Scientific
New challenges in HIV research
Forty years after its discovery, HIV/AIDS has become a chronic disease thanks to triple therapy. But it still resists being cured and the vaccine is still awaited...
Monsef Benkirane, virologist at the Institute of Human Genetics, takes stock of the new research challenges.
Axel Kahn "being human"
In tribute to Axel Kahn who passed away on 6 July 2021, the IGH looks back on a rich day during which Axel Kahn honoured us with his presence.
On April 15, 2016 Axel Kahn spoke at the Genopolys amphitheatre as part of the Citizens' Days. The conference inaugurated the EUREKA cycle, with a reflection on the human being, this animal endowed with reason.
Open Group Leader Position
The Institute of Human Genetics of Montpellier (IGH) opens a call for applications to a Principal Investigator position in its main areas of interest, namely Genome Dynamics, Genomics, RNA Biology, Computational Biology and AI, Epigenetics, Immunogenetics, Developmental Biology, Cancer and Infectious Diseases.
New research will take place into an aggressive brain tumour
Genome Surveillance and StabilityNew research will take place into the rare disease after charity Worldwide Cancer Research donated almost £200,000 to a French doctor's project.
The research is led by Dr Domenico Maiorano to better understand how a gene in DNA allows brain cancer cells to survive and grow.
The Montpellier start-up working on a future treatment against glaucoma awarded by the Cercle Mozart
The Cercle Mozart presented its medical start-up prize yesterday to the Montpellier biotech company MT-Act. On this occasion, the start-up created in 2019 received a check for € 20,000 and will benefit from the support of the association for three years to develop its network.
Nature publication by the LifeTime Initiative: Improving Healthcare and Healthcare Systems in Europe Through "Interceptive" Cellular Medicine
The LifeTime initiative, in which the Institute of Human Genetics (IGH), the CNRS and the Institut Curie participate, brings together hundreds of researchers, clinicians, industry leaders and policy makers both in France and in Europe. Together, they publish their LifeTime Strategic Research Agenda as well as an article in Nature on September 7, 2020, providing their vision and a roadmap for the coming decade.
