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MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling
Nat Commun. 2024
Maintenance of genome integrity during DNA replication
Principles of chromosome organization for meiotic recombination
Mol Cell. 2024
Meiosis and recombination
Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
Cell Reports 2024
Genetic Instability and Cancer
Chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms
Development 2023
Neurogenetics and memory
A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation.
Sci Adv 2023
Tubulin code
Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
Molecular Cell 2023
Genetic Instability and Cancer
PAPγ associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs
Nature Communications 2023
Gene regulation
POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape from innate immune sensing
Science Advances 2023
Laboratory of Molecular Virology
Transposable elements acquire time-and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development
Front. Cell Dev. Biol. 2024
Development and Pathology of the gonad
RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart
The EMBO Journal 2023
Maintenance of genome integrity during DNA replication
Two redundant transcription factor binding sites in a single enhancer are essential for mammalian sex determination
Nucleic Acids Res 2024
Development and Pathology of the gonad
Transient loss of Polycomb components induces an epigenetic cancer fate.
Nature 2024
Chromatin and cell biology
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer-promoter communication.
Nat Struct Mol Biol 2024
Chromatin and cell biology
Spatial organization of translation and translational repression in two phases of germ granules
Nature Communications 2024
mRNA Regulation and Development
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The Institute of Human Genetics is dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology
3
DEPARTMENTS
26
RESEARCH TEAMS
1516
PUBLICATIONS
12
ERC LAUREATES
(7 Adv, 2 StG, 2 COG & 1PoC)
55
PHD THESES AND HDR DEFENCES
Headlines
Ph. Pasero elected to EMBO Membership
Marcel elected as member of The Academy of Europe
Martine, Séverine & Kaz awarded of FRM Occitanie
Research departments
Molecular Bases of Human Diseases
High quality research in the fields of immunology and cancer
Genome Dynamics
Research on understanding the multiple activities of the genome in various model systems
Genetics, Cell Biology and Development
Understand genetic information translated into the production of many different cell types
Last publications
All publications
A case of refractory IgG4-related disease successfully...
Rheumatology (Oxford) 2024
Epigenome modifications and genomic instability in normal and malignant B cells
FCGR3A F158V alleles frequency differs in multiple...
Oncoimmunology 2024
Epigenome modifications and genomic instability in normal and malignant B cells
A new perspective on microRNA-guided gene regulation...
Nucleic Acids Res 2024
Systemic impact of small regulatory RNAs
FIGNL1-FIRRM is essential for meiotic recombination...
Nat Commun. 2024
Meiosis and recombination
The TOPOVIBL meiotic DSB formation protein: new insights...
Nucleic Acids Res . 2024
Meiosis and recombination
Mapping Meiotic DNA Breaks: Two Fully-Automated Pipelines...
Methods Mol Biol. 2024
Meiosis and recombination
Quantitative Integrative Survival Prediction in Multiple...
JCO Precis Oncol 2024
Epigenome modifications and genomic instability in normal and malignant B cells
Brexucabtagene autoleucel in relapsed or refractory...
Haematologica 2024
Epigenome modifications and genomic instability in normal and malignant B cells
Flow cytometric analysis of peripheral blood neutrophil...
BMJ Open 2024
Epigenome modifications and genomic instability in normal and malignant B cells
Genome organization: Raison d'être of ancestral linkage...
Curr Biol 2024
Epigenetic Chromatin Regulation
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MBHD Dpt. Seminar Series
IGH Seminar Series of the Department “Molecular basis of Human Diseases”
from 02/04/2024 until 11/10/2024 11:30 - 14:00
Genopolys amphitheater
GCB&D Dpt. Seminar Series
IGH Seminar Series of the Department “Genetics, Cell Biology and Development”
from 19/02/2024 until 15/11/2024
Genopolys amphitheater
Seminars
Regulation of large-scale chromatin architecture in human cells
20/09/2024 11:30 Genopolys
Evolution of Drosophila glue, a promising system for biomimetic applications
25/09/2024 11:30 IGH seminar room
Dual DNA demethylation mechanisms implement epigenetic memory triggered by the pioneer factor Pax7
Chromatin and cell biology
26/09/2024 11:30 Genopolys Amphitheatre
All seminars
Congresses
Epigenetics and Chromatin Dynamics in Homeostasis and Disease
Chromatin and cell biology
24/09/2024 13:30 Genopolys amphitheater
Integrated approaches to fight colorectal cancer: all together to break down barriers
25/09/2024 09:00 - 13:30 IRCM, Montpellier
CBS2 day 2024
26/09/2024 Université Montpellier, Fr
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