Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression
Published the 13/12/2022 - Cell Reports
, https://doi.org/10.1016/j.celrep.2022.111784
Kalina Timcheva, Solenne Dufour, Leila Touat-Todeschini, Callum Burnard, Marie-Christine Carpentier, Florent Chuffart, Rémy Merret, Marion Helsmoortel, Sabrina Ferré, Aude Grézy, Yohann Couté, Sophie Rousseau, Saadi Khochbin, Claire Vourc’h, Cécile Bousquet-Antonelli, Rosemary Kiernan, Daphné Seigneurin-Berny and André Verdel
read publication
more
The Polyvalent Role of NF90 in RNA Biology
Published the 05/11/2022 - International Journal of Molecular Sciences
Giuseppa Grasso and Rosemary Kiernan
more
NF90 interacts with components of RISC and modulates association of Ago2 with mRNA.
Published the 02/09/2022 - BMC Biol
, 20(1):194 36050755
Grasso G*, Akkawi C*, Franckhauser C, Nait-Saidi R, Bello M, Barbier J, Kiernan R
NF90 Interacts with Components of RISC and Modulates Association of Ago2 with mRNA
Published the 26/01/2022 - BioRxiv
, doi: https://doi.org/10.1101/2021.09.23.461467
Giuseppa Grasso, Charbel Akkawi, Celine Franckhauser, Rima Nait-Saidi, Maxime Bello, Jérôme Barbier, Rosemary Kiernan
more
Chromatin-associated MRN complex protects highly transcribing genes from genomic instability
Published the 21/05/2021 - Science Advances
Kader Salifou, Callum Burnard, Poornima Basavarajaiah, Marion Helsmoortel, Victor Mac, David Depierre, Giuseppa Grasso, Céline Franckhauser, Emmanuelle Beyne, Xavier Contreras, Jérôme Dejardin, Sylvie Rouquier, Olivier Cuvier, Rosemary Kiernan
more
PAF1 facilitates RNA polymerase II ubiquitination by the Elongin A complex through phosphorylation by CDK12
Published the 17/09/2020 - BioRxiv
Gabriel Sanchez, Jérôme Barbier, Céline Elie, Rosemary Kiernan, Sylvie Rouquier
more
NF90 modulates processing of a subset of human pri-miRNAs
Published the 19/05/2020 - Nucleic Acids Research
Grasso G, Higuchi T, Mac V, Barbier J, Helsmoortel M, Lorenzo C, Sanchez G, Bello M, Ritchie W, Sakamoto S, and Kiernan R.
more
[Nuclear RNA surveillance complexes control HIV-1 transcription].
Published the 19/02/2019 - Med Sci (Paris)
, 35(2):113-115 30774074
Salifou K, Kiernan R, Contreras X
An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression.
Published the 23/03/2018 - Cell Res
, 28(5):556-571 29563539
Barbier J, Chen X, Sanchez G, Cai M, Helsmoortel M, Higuchi T, Giraud P, Contreras X, Yuan G, Feng Z, Nait-Saidi R, Deas O, Bluy L, Judde JG, Rouquier S, Ritchie W, Sakamoto S, Xie D, Kiernan R
+
Machine learning and gene regulation
Nuclear RNA surveillance complexes silence HIV-1 transcription.
Published the 20/03/2018 - PLoS Pathog
, 14(3):e1006950 29554134
Contreras X, Salifou K, Sanchez G, Helsmoortel M, Beyne E, Bluy L, Pelletier S, Rousset E, Rouquier S, Kiernan R
Identification of histone 3 variant 2 interacting factors
Published the 01/01/2014 - Nucleic Acids Res.
, 42,6, 3542-3550 24393775
Latreille D, Bluy L, Benkirane M, Kiernan RE.
+
Laboratory of Molecular Virology
Premature termination of transcription by RNAP II: The beginning of the end.
Published the 01/01/2013 - Transcription
, 4(2):72-6. 23714697
Contreras X, Benkirane M, Kiernan R.
+
Laboratory of Molecular Virology
Microprocessor, Setx, Xrn2 and Rrp6 Co-Operate to Induce Premature Termination of Transcription by RNAPII
Published the 01/01/2012 - CELL
, 150, 1147-1157, http://dx.doi.org/10.1016/J.cell.2012.08.004 22980978
Wagschal, A., Rousset, E., Basavarajaiah, P., Contreras, X. , Harwig, A., Laurent-Chabalier, S. , Nakamura, M., Chen, X., Zhang, K., Meziane, O., Boyer, F., Parrinello, H., Berkhout, B., Terzian, C., Benkirane, M., Kiernan, R.
+
Laboratory of Molecular Virology
Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR
Published the 01/01/2012 - Retrovirology
, 9(1):13 22316138
Nakamura M, Basavarajaiah P, Rousset E, Beraud C, Latreille D, Henaoui IS, Lassot I, Mari B, Kiernan R.
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP
Published the 01/01/2010 - Molecular Cell
, 38, 3, 439-451 20471949
Sobhian, B., Laguette, N., Yatim, A., Nakamura, M., Levy, Y., Kiernan, R., Benkirane, M.
+
Laboratory of Molecular Virology
Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post integration latency.
Published the 01/01/2007 - EMBO.J.
, 26(2):424-35. 17245432
du Chéné, I., Basyuk, E., Lin,YL., Triboulet, R., Knezevich, A., Chable-Bessia, C., Mettling, C., Baillat, V., Reynes, J., Corbeau, P., Bertrand, E., Marcello, A., Emiliani, S., Kiernan, R., Benkirane, M.
+
Laboratory of Molecular Virology
Intrinsic ubiquitylation activity of PCAF controls the stability of the oncoprotein Hdm2
Published the 01/01/2007 - Nature Cell Biology
, 9(3):331-338 17293853
Linares, Laetitia, Rosemary Kiernan, Robinson Triboulet, Christine Chable-Bessia, Daniel Latreille, Olivier Cuvier, Matthieu Lacroix, Laurent Le Cam, Olivier Coux, and Monsef Benkirane.
+
Laboratory of Molecular Virology
The Proteasome Regulates HIV-1 Transcription by Both Proteolytic and Non-Proteolytic Mechanisms
Published the 01/01/2007 - Molecular Cell
, 25, 369-383 17289585
Lassot, L., Latreille, D., Rousset, E., Sourisseau, M., Linares, L.K., Chable-Bessia, C., Coux, O., Benkirane, M., Kiernan, R.
+
Laboratory of Molecular Virology
The HIV-1 Tat protein stimulates reverse transcription in vitro.
Published the 01/01/2007 - Curr. HIV Res.
, 5 ,5, 473-483 17896967
Apolloni, A., Meredith, LW., Suhrbier, A., Kiernan, R., Harrich, D
+
Laboratory of Molecular Virology
Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter.
Published the 01/01/2006 - EMBO J.
, 25, 1690-1699 16601680
Treand C, du Chene I, Bres V, Kiernan R, Benarous R, Benkirane M, Emiliani S.
+
Laboratory of Molecular Virology
A non proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter
Published the 01/01/2003 - Nature Cell Biology
, 5, 754-761
Vanessa Brès, Rosemary E. Kiernan, Laetitia K. Linares, Christine Chable-Bessia, Olga Plechakova, Céline Tréand, Stephane Emiliani, Jean-Marie Peloponese, Kuan-Teh Jeang, Olivier Coux, Martin Scheffner, and Monsef Benkirane
+
Laboratory of Molecular Virology
Tat acetyl-acceptor lysines are important for Human Immunodeficiency Virus type-1 replication
Published the 01/01/2002 - J. Biol. Chem. 277
, 22215-22221
Brès, V., Rosemary Kiernan, Stéphane Emiliani and Monsef Benkirane
+
Laboratory of Molecular Virology
Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF.
Published the 01/01/2002 - EMBO.J.
, 21:6811-6819
Brès V. Tagami H. Péloponèse J.M. Loret E. Jeang K-T. Nakatani Y. Emiliani S. Benkirane M. and Kiernan ER.
+
Laboratory of Molecular Virology
Interaction between cyclin T1 and SCFSKP2 targets CDK9 for ubiquitination and degradation by the proteasome.
Published the 01/01/2001 - Mol. Cell. Biol.
, 21 (23), 7956-7970
Kiernan, R., Emiliani, S., Nakayama, K., Castro, A., Labbé, J.C., Lorca, T., Nakayama, K.-I., and Benkirane, M.
+
Laboratory of Molecular Virology
HIV-1 Tat transcriptional activity is regulated by acetylation.
Published the 01/01/1999 - EMBO J.
, 18, 6106-6118.
Kiernan, R., Vanhulle, C., Schiltz, L., Adam, E., Xiao, H., Maudoux, F., Calomme, C., Burny, A., Nakatani, Y., Jeang, K.-T., Benkirane, M. and Van Lint, C.
+
Laboratory of Molecular Virology