Publications
Toxic R-loops: Cause or consequence of replication stress?
Maintenance of genome integrity during DNA replicationSamira Kemiha, Jérôme Poli, Yea-Lih Lin, Armelle Lengronne, Philippe Pasero
Chromatin-associated MRN complex protects highly transcribing genes from genomic instability
Gene regulationKader Salifou, Callum Burnard, Poornima Basavarajaiah, Marion Helsmoortel, Victor Mac, David Depierre, Giuseppa Grasso, Céline Franckhauser, Emmanuelle Beyne, Xavier Contreras, Jérôme Dejardin, Sylvie Rouquier, Olivier Cuvier, Rosemary Kiernan
Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes.
Molecular Basis of InflammationTaffoni C, Steer A, Marines J, Chamma H, Vila IK, Laguette N
Discovery of candidate DNA methylation cancer driver genes.
Epigenome modifications and genomic instability in normal and malignant B cellsPan H, Renaud L, Chaligne R, Bloehdorn J, Tausch E, Mertens D, Fink AM, Fischer K, Zhang C, Betel D, Gnirke A, Imielinski M, Moreaux J, Hallek M, Meissner A, Stilgenbauer S, Wu CJ, Elemento O, Landau DA
Understanding 3D genome organization by multidisciplinary methods
Chromatin and cell biologyIvana Jerkovic´ & Giacomo Cavalli
Histone marks are drivers of the splicing changes necessary for an epithelial-to-mesenchymal transition
Chromatin and SplicingAlexandre Segelle, Yaiza Nunez-Alvarez, Andrew J Oldfield, Kimberly M Webb, Philipp Voigt, Reini F Luco
A cell-to-patient machine learning transfer approach uncovers novel basal-like breast cancer prognostic markers amongst alternative splice variants
Chromatin and SplicingJean-Philippe Villemin, Claudio Lorenzi, Marie-Sarah Cabrillac, Andrew Oldfield, William Ritchie & Reini F. Luco
Translesion Synthesis or Repair by Specialized DNA Polymerases Limits Excessive Genomic Instability upon Replication Stress.
Genome Surveillance and StabilityMaiorano D, El Etri J, Franchet C, Hoffmann JS
Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling
Neurogenetics and memoryAna Boulanger, Camille Thinat, Stephan Züchner, Lee G. Fradkin, Hugues Lortat-Jacob & Jean-Maurice Dura
TopBP1 assembles nuclear condensates to switch on ATR signaling.
Genetic Instability and CancerFrattini C, Promonet A, Alghoul E, Vidal-Eychenie S, Lamarque M, Blanchard MP, Urbach S, Basbous J, Constantinou A
Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis
Cell Biology of RNAOh Sung Kwon, Rahul Mishra, Adham Safieddine, Emeline Coleno, Quentin Alasseur, Marion Faucourt, Isabelle Barbosa, Edouard Bertrand, Nathalie Spassky & Hervé Le Hir
A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport
Cell Biology of RNAAdham Safieddine, Emeline Coleno, Soha Salloum, Arthur Imbert, Abdel-Meneem Traboulsi, Oh Sung Kwon, Frederic Lionneton, Virginie Georget, Marie-Cécile Robert, Thierry Gostan, Charles-Henri Lecellier, Racha Chouaib, Xavier Pichon, Hervé Le Hir, Kazem Zibara, Florian Mueller, Thomas Walter, Marion Peter & Edouard Bertrand
Regulation of the conserved 3'-5' exoribonuclease EXOSC10/Rrp6 during cell division, development and cancer.
Mammalian Cell BiologyStuparević I, Novačić A, Rahmouni AR, Fernandez A, Lamb N, Primig M
Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition.
Chromatin and SplicingAgirre E, Oldfield AJ, Bellora N, Segelle A, Luco RF
Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation.
mRNA Regulation and DevelopmentBamia A, Sinane M, Naït-Saïdi R, Dhiab J, Keruzoré M, Nguyen PH, Bertho A, Soubigou F, Halliez S, Blondel M, Trollet C, Simonelig M, Friocourt G, Béringue V, Bihel F, Voisset C
Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses
Molecular Basis of InflammationIsabelle K. Vila, Hanane Chamma, Alizée Steer, Clara Taffoni, Line S. Reinert, Evgenia Turtoi, Mathilde Saccas, Johanna Marines, Lei Jin, Xavier Bonnefont, Soren R. Paludan, Dimitrios Vlachakis, Andrei Turtoi, Nadine Laguette
Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics. Nat. Comm, in revision.
Cell Biology of RNAPimmett, L., Dejean, M., Fernandez, C., Trullo, A., Bertrand, E., Radulescu, O., and M. Lagha.