Mutation hotspots during meiosis
Meiosis and recombinationBaudat, F. de Massy, B.
Publications
RNA-sequencing based first choice of treatment and determination of risk in multiple myeloma.
Epigenome modifications and genomic instability in normal and malignant B cellsEmde-Rajaratnam M, Beck S, Benes V, Salwender H, Bertsch U, Scheid C, Hänel M, Weisel K, Hielscher T, Raab MS, Goldschmidt H, Jauch A, Maes K, De Bruyne E, Menu E, De Veirman K, Moreaux J, Vanderkerken K, Seckinger A, Hose D
POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape from innate immune sensing
Laboratory of Molecular VirologySuzie Thenin-Houssier, Shinichi Machida, Cyprien Jahan, Lucie Bonnet-Madin, Scarlette Abbou, Heng-Chang Chen, Robel Tesfaye, Olivier Cuvier, Monsef Benkirane
Extreme thrombocytosis with an aggressive evolution harboring a novel variant of calreticulin (CALR) in exon 3.
Epigenome modifications and genomic instability in normal and malignant B cellsBonnet S, Carillo S, Legrand B, Burroni B, Lavabre-Bertrand T, Requirand G, Robert N, Fornero L, Al Mansoori A, Moreaux J, Cartron G, Gabellier L, Herbaux C
PAPγ associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs
Gene regulationXavier Contreras, David Depierre, Charbel Akkawi, Marina Srbic, Marion Helsmoortel, Maguelone Nogaret, Matthieu LeHars, Kader Salifou, Alexandre Heurteau, Olivier Cuvier, Rosemary Kiernan
RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart
Maintenance of genome integrity during DNA replication
Chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms
Neurogenetics and memoryClarisse Perron, Pascal Carme, Arnau Llobet Rosell, Eva Minnaert, Salomé Ruiz Demoulin, Héloïse Szczkowski, Lukas Jakob Neukomm, Jean-Maurice Dura and Ana Boulanger
A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation.
Tubulin codeNicot S, Gillard G, Impheng H, Joachimiak E, Urbach S, Mochizuki K, Wloga D, Juge F, Rogowski K
Metazoan nuclear pore complexes in gene regulation and genome stability.
Nuclear architecture in physiology and pathologyNobari P, Doye V, Boumendil C
Non-Relapse Mortality after CAR T-Cell therapy for Large B-Cell Lymphoma: A LYSA Study from the DESCAR-T Registry.
Epigenome modifications and genomic instability in normal and malignant B cellsLemoine J, Bachy E, Cartron G, Beauvais D, Gastinne T, Di Blasi R, Rubio MT, Guidez S, Mohty M, Casasnovas O, Joris M, Castilla-Llorente C, Haioun C, Hermine O, Loschi M, Carras S, Bories P, Fradon T, Herbaux C, Sesques P, Le Gouill S, Morschhauser F, Thieblemont C, Houot R
EZH2 targeting induces CD38 upregulation and response to anti-CD38 immunotherapies in multiple myeloma.
Epigenome modifications and genomic instability in normal and malignant B cellsChemlal D, Varlet E, Machura A, Ovejero S, Requirand G, Robert N, Cartron G, Alaterre E, Bret C, Vincent L, Herbaux C, Cavalli G, Bruyer A, De Boussac H, Moreaux J
S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma.
Epigenome modifications and genomic instability in normal and malignant B cellsWang Y, Muylaert C, Wyns A, Vlummens P, De Veirman K, Vanderkerken K, Zaal E, Berkers C, Moreaux J, De Bruyne E, Menu E
Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation
Meiosis and recombinationLaroussi, H. Juarez-Martinez, A. B. Le Roy, A. Boeri Erba, E. Gabel, F. de Massy, B. Kadlec, J.
Evaluation of microRNA variant maturation prior to genome edition.
Systemic impact of small regulatory RNAsBusseau I, Mockly S, Houbron É, Somaï H, Seitz H
Detection of endogenous translesion DNA synthesis in single mammalian cells
Genome Surveillance and StabilityEgger T, Aze A, Maiorano D
Compartmentalization of the DNA damage response: Mechanisms and functions
Genetic Instability and CancerALGHOUL Emile, BASBOUS Jihane, CONSTANTINOU Angelos
The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons.
Neurogenetics and memoryJi H, Wang B, Shen Y, Labib D, Lei J, Chen X, Sapar M, Boulanger A, Dura JM, Han C
Biochemistry-informed design selects potent siRNAs against SARS-CoV-2.
Systemic impact of small regulatory RNAsHoubron É, Mockly S, Rafasse S, Gros N, Muriaux D, Seitz H