TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks
Nore, A. Juarez-Martinez, A. B. Clement, J. Brun, C. Diagouraga, B. Laroussi, H. Grey, C. Bourbon, H. M. Kadlec, J. Robert, T. de Massy, B.
In sexually reproducing species, meiosis allows the formation of haploid gametes from diploid cells. The halving of the DNA content results from a specialized cell cycle, where a single phase of DNA replication is followed by two divisions. The reductional segregation of homologous chromosomes (homologues) at the first meiotic division requires the establishment of connections between homologues. In most species, these connections are established during a long and specialized prophase by reciprocal exchanges between homologues. These exchanges, also called crossing over, result from a highly regulated homologous recombination pathway that drives the recognition and interaction between homologues and the formation of at least one crossing over per homologue pair. Crossovers also generate new allele combinations and thus increase genetic diversity and contributes to genome evolution. The absence of crossover leads to chromosome segregation defects and sterility, and alteration of the meiotic recombination pathway can lead to genome rearrangements and aneuploidy.
Our team is investigating several aspects of the mechanism and regulation of meiotic recombination and its evolutionary implication using the mouse as a model system. Meiotic recombination events are initiated by the formation of DNA double-strand breaks (DSBs, several hundred per nucleus in mice), the repair of which leads to both crossovers and non-crossovers (gene conversion without crossover). The main steps and factors involved in this pathway are evolutionary conserved.
Nore, A. Juarez-Martinez, A. B. Clement, J. Brun, C. Diagouraga, B. Laroussi, H. Grey, C. Bourbon, H. M. Kadlec, J. Robert, T. de Massy, B.
Brinkmeier, J. Coelho, S. de Massy, B. Bourbon, H. M.
Ihsan Dereli, Marcello Stanzione, Fabrizio Olmeda, Frantzeskos Papanikos, Marek Baumann, Sevgican Demir, Fabrizia Carofiglio, Julian Lange, Bernard de Massy, Willy M Baarends, James Turner, Steffen Rulands, Attila Tóth
Grey C, de Massy B
Zhong-Yi Wang, Evgeny Leushkin, Angélica Liechti, Svetlana Ovchinnikova, Katharina Mößinger, Thoomke Brüning, Coralie Rummel, Frank Grützner, Margarida Cardoso-Moreira, Peggy Janich, David Gatfield, Boubou Diagouraga, Bernard de Massy, Mark E. Gill, Antoine H. F. M. Peters, Simon Anders & Henrik Kaessmann
Imai Y, Biot M, Clément J, Teragaki M, Urbach S, Robert T, Baudat F, Grey C, de Massy B
Biot M, de Massy B
Papanikos F, Clément JAJ, Testa E, Ravindranathan R, Grey C, Dereli I, Bondarieva A, Valerio-Cabrera S, Stanzione M, Schleiffer A, Jansa P, Lustyk D, Fei JF, Adams IR, Forejt J, Barchi M, de Massy B, Toth A
Baudat F, de Massy B, Veyrunes F
Kumar R, Oliver C, Brun C, Juarez-Martinez AB, Tarabay Y, Kadlec J, de Massy B
Grey C, Baudat F, de Massy B
Diagouraga B, Clément JAJ, Duret L, Kadlec J, de Massy B, Baudat F
Robert, T, De Massy, B, Grelon, M.
Grey C, Clément JA, Buard J, Leblanc B, Gut I, Gut M, Duret L, de Massy B.
Imai Y, Baudat F, Taillepierre M, Stanzione M, Toth A, de Massy B.
Clément J, de Massy B
Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B
Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A
Grey C, Espeut J, Ametsitsi R, Kumar R, Luksza M, Brun C, Verlhac MH, Suja JÁ, de Massy B
Robert T, Vrielynck N, Mézard C, de Massy B, Grelon M
Kumar R, Ghyselinck N, Ishiguro KI, Watanabe Y, Kouznetsova A, Höög C, Strong E, Schimenti J, Daniel K, Toth A, de Massy B.
Borde V, de Massy B
Doyen CM1, Chalkley GE1, Voets O1, Bezstarosti K2, Demmers JA2, Moshkin YM1, Verrijzer CP3.
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Laboratory of Molecular Virology
Rahmoun M, Perez J, Saunders PA, Boizet-Bonhoure B, Wilhelm D, Poulat F, Veyrunes F.
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Development and Pathology of the gonad
Buard J, Rivals E, Dunoyer de Segonzac D, Garres C, Caminade P, de Massy B, Boursot P.
Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M.
de Massy B.
Baudat F, Imai Y, de Massy B.
Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec J.
De massy, B.
Soumillon M, Necsulea A, Weier M, Brawand D, Zhang X, Gu H, Barthès P, Kokkinaki M, Nef S, Gnirke A, Dym M, de Massy B, Mikkelsen TS, Kaessmann H.
Carofiglio F, Inagaki A, de Vries S, Wassenaar E, Schoenmakers S, Vermeulen C, van Cappellen WA, Sleddens-Linkels E, Grootegoed JA, Te Riele HP, de Massy B, Baarends WM.
Ishmukhametova A, Chen JM, Bernard R, de Massy B, Baudat F, Boyer A, Méchin D, Thorel D, Chabrol B, Vincent MC, Van Kien PK, Claustres M, Tuffery-Giraud S.
Orsi GA, Algazeery A, Meyer RE, Capri M, Sapey-Triomphe LM, Horard B, Gruffat H, Couble P, Aït-Ahmed O, Loppin B.
Borde V, de Massy B.
De Massy, B.
Psomas C, Lavigne JP, Barbuat C, Trabelsi S, Ghosn J, Lascoux-Combe C, Flandre P, Cuzin L, Reynes J, Autran B, Corbeau P.
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Homing, immune activation and infection
Reynolds A, Qiao H, Yang Y, Chen JK, Jackson N, Biswas K, Holloway JK, Baudat F, de Massy B, Wang J, Höög C, Cohen PE, Hunter N.
Flachs P, Mihola O, Simeček P, Gregorová S, Schimenti JC, Matsui Y, Baudat F, de Massy B, Piálek J, Forejt J, Trachtulec Z.
Romero Y, Vuandaba M, Suarez P, Grey C, Calvel P, Conne B, Pearce D, de Massy B, Hummler E, Nef S.
Lutzmann M, Grey C, Traver S, Ganier O, Maya-Mendoza A, Ranisavljevic N, Bernex F, Nishiyama A, Montel N, Gavois E, Forichon L, de Massy B, Méchali M.
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Replication and Genome Dynamics
Grey C, Sommermeyer V, Borde V, de Massy B
Grad I, Cederroth CR, Walicki J, Grey C, Barluenga S, Winssinger N, De Massy B, Nef S, Picard D
Lichten, M., de Massy, B.
Grey C, Barthès P, Chauveau-Le Friec G, Langa F, Baudat F, de Massy B.
Baudat F, Buard J, Grey C, de Massy B.
Romero Y, Meikar O, Papaioannou MD, Conne B, Grey C, Weier M, Pralong F, De Massy B, Kaessmann H, Vassalli JD, Kotaja N, Nef S.
Baudat, F., Buard, J., Grey, C., Fledel-Alon, A., Ober, C., Przeworski, M., Coop, G., de Massy, B.
Kumar, R., Bourbon, H.M., De Massy, B.
Baudat F, Buard J, Grey C, de Massy B.
Meyer, RE., Delaage, M., Rosset, R., Capri, M., Ait-Ahmed, O.
Baudat, F. and de Massy, B.
Grey C, Baudat F, de Massy B.
Bolcun-Filas, E., Speed, R., Taggart, M., Grey, C., de Massy, B., Benavente, R., Cooke, HJ.
Buard, J., Barthès, P., Grey, C. and de Massy, B_.
Svetlanov A, Baudat F, Cohen PE, de Massy B.
Le Mée, G., Ezzeddine, N., Capri, M., Aït-Ahmed, O.
Chicheportiche A, Bernardino-Sgherri J, de Massy B, Dutrillaux B.
Baudat, F., de Massy, B
Baudat, F., de Massy, B.
Buard, J., De Massy, B.
Cosson, B., Gautier-Courteille, C., Maniey, D., Ait-Ahmed, O., Lesimple, M., Osborne, H.B., Paillard, L.
Bérard S., Buard J. et E. Rivals.
Alkan, C., Tuzun, E., Buard, J., Lethiec, F., Eichler, EE., Bailey JA., Sahinalp, SC.
Guettier, C., Sebagh, M., Buard, J., Feneux, D., Ortin-Serrano, M., Gigou, M., Tricottet, V., Reynes, M., Samuel, D., Feray, C.
Guillon, H., Baudat, F., Grey, C., Liskay, R.M. and de Massy, B
Delaunay J, Le Mée G, Ezzeddine N, Labesse G, Terzian C, Capri M, Aït-Ahmed O.
Lemaitre, JM., Bocquet, S., Terret, ME., Namdar, M., Ait-Ahmed, O., Kearsey, S., Verlhac, MH., and Méchali, M.
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Replication and Genome Dynamics
Laurent, A. M., Li, M., Sherman, S., Roizes, G., Buard, J.,
de Massy, B.
Ezzeddine, N., Paillard, L., Capri, M., Maniey, D., Bassez, T., Aït-Ahmed, O. and Osborne, H.B.
Lopes J., Debrauwere H., Buard J., Nicolas A.
Buard J., Brenner C., Jeffreys A.J.
Guillon H. and de Massy B.
Metzler-Guillemain, C. et de Massy B.
Buard J., Collick A., Brown J. and Jeffreys, A.J.
Debrauwere H., Nicolas A., Vergnaud G., Buard J., Tessier J. et Aubert D.
Stead JD, Buard J, Todd JA, Jeffreys AJ.
Buard, J., Shone, A.C. and Jeffreys, A.J.
Gangloff, S., De Massy, B., Lane, A., Rothstein, R. and Fabre, F.
Debrauwere H, Buard J, Tessier J, Aubert D, Vergnaud G, Nicolas A.
Capri, M., Santoni, M.J., Thomas-Delaage, M. and Aït-Ahmed, O.
Dardhalon, M., De Massy, B., Nicolas, A. and Averbeck, D.
Santoni, M.J., Aït-Ahmed, O. and Marilley, M.