PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.
Imai Y, Biot M, Clément J, Teragaki M, Urbach S, Robert T, Baudat F, Grey C, de Massy B
In sexually reproducing species, meiosis allows the formation of haploid gametes from diploid cells. The halving of the DNA content results from a specialized cell cycle, where a single phase of DNA replication is followed by two divisions. The reductional segregation of homologous chromosomes (homologues) at the first meiotic division requires the establishment of connections between homologues. In most species, these connections are established during a long and specialized prophase by reciprocal exchanges between homologues. These exchanges, also called crossing over, result from a highly regulated homologous recombination pathway that drives the recognition and interaction between homologues and the formation of at least one crossing over per homologue pair. Crossovers also generate new allele combinations and thus increase genetic diversity and contributes to genome evolution. The absence of crossover leads to chromosome segregation defects and sterility, and alteration of the meiotic recombination pathway can lead to genome rearrangements and aneuploidy.
Our team is investigating several aspects of the mechanism and regulation of meiotic recombination and its evolutionary implication using the mouse as a model system. Meiotic recombination events are initiated by the formation of DNA double-strand breaks (DSBs, several hundred per nucleus in mice), the repair of which leads to both crossovers and non-crossovers (gene conversion without crossover). The main steps and factors involved in this pathway are evolutionary conserved.
Imai Y, Biot M, Clément J, Teragaki M, Urbach S, Robert T, Baudat F, Grey C, de Massy B
Biot M, de Massy B
Papanikos F, Clément JAJ, Testa E, Ravindranathan R, Grey C, Dereli I, Bondarieva A, Valerio-Cabrera S, Stanzione M, Schleiffer A, Jansa P, Lustyk D, Fei JF, Adams IR, Forejt J, Barchi M, de Massy B, Toth A
Baudat F, de Massy B, Veyrunes F
Kumar R, Oliver C, Brun C, Juarez-Martinez AB, Tarabay Y, Kadlec J, de Massy B
Grey C, Baudat F, de Massy B
Diagouraga B, Clément JAJ, Duret L, Kadlec J, de Massy B, Baudat F
Grey C, Clément JA, Buard J, Leblanc B, Gut I, Gut M, Duret L, de Massy B.
Imai Y, Baudat F, Taillepierre M, Stanzione M, Toth A, de Massy B.
Robert, T, De Massy, B, Grelon, M.
Clément J, de Massy B
Grey C, Espeut J, Ametsitsi R, Kumar R, Luksza M, Brun C, Verlhac MH, Suja JÁ, de Massy B
Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B
Robert T, Vrielynck N, Mézard C, de Massy B, Grelon M
Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A
Kumar R, Ghyselinck N, Ishiguro KI, Watanabe Y, Kouznetsova A, Höög C, Strong E, Schimenti J, Daniel K, Toth A, de Massy B.
Borde V, de Massy B
Buard J, Rivals E, Dunoyer de Segonzac D, Garres C, Caminade P, de Massy B, Boursot P.
Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M.
de Massy B.
De Massy, B.
Borde V, de Massy B.
Reynolds A, Qiao H, Yang Y, Chen JK, Jackson N, Biswas K, Holloway JK, Baudat F, de Massy B, Wang J, Höög C, Cohen PE, Hunter N.
Orsi GA, Algazeery A, Meyer RE, Capri M, Sapey-Triomphe LM, Horard B, Gruffat H, Couble P, Aït-Ahmed O, Loppin B.
Ishmukhametova A, Chen JM, Bernard R, de Massy B, Baudat F, Boyer A, Méchin D, Thorel D, Chabrol B, Vincent MC, Van Kien PK, Claustres M, Tuffery-Giraud S.
Carofiglio F, Inagaki A, de Vries S, Wassenaar E, Schoenmakers S, Vermeulen C, van Cappellen WA, Sleddens-Linkels E, Grootegoed JA, Te Riele HP, de Massy B, Baarends WM.
Soumillon M, Necsulea A, Weier M, Brawand D, Zhang X, Gu H, Barthès P, Kokkinaki M, Nef S, Gnirke A, Dym M, de Massy B, Mikkelsen TS, Kaessmann H.
De massy, B.
Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec J.
Baudat F, Imai Y, de Massy B.
Flachs P, Mihola O, Simeček P, Gregorová S, Schimenti JC, Matsui Y, Baudat F, de Massy B, Piálek J, Forejt J, Trachtulec Z.
Romero Y, Vuandaba M, Suarez P, Grey C, Calvel P, Conne B, Pearce D, de Massy B, Hummler E, Nef S.
Grad I, Cederroth CR, Walicki J, Grey C, Barluenga S, Winssinger N, De Massy B, Nef S, Picard D
Grey C, Sommermeyer V, Borde V, de Massy B
Lichten, M., de Massy, B.
Romero Y, Meikar O, Papaioannou MD, Conne B, Grey C, Weier M, Pralong F, De Massy B, Kaessmann H, Vassalli JD, Kotaja N, Nef S.
Grey C, Barthès P, Chauveau-Le Friec G, Langa F, Baudat F, de Massy B.
Baudat F, Buard J, Grey C, de Massy B.
Baudat, F., Buard, J., Grey, C., Fledel-Alon, A., Ober, C., Przeworski, M., Coop, G., de Massy, B.
Kumar, R., Bourbon, H.M., De Massy, B.
Baudat F, Buard J, Grey C, de Massy B.
Meyer, RE., Delaage, M., Rosset, R., Capri, M., Ait-Ahmed, O.
Baudat, F. and de Massy, B.
Grey C, Baudat F, de Massy B.
Bolcun-Filas, E., Speed, R., Taggart, M., Grey, C., de Massy, B., Benavente, R., Cooke, HJ.
Buard, J., Barthès, P., Grey, C. and de Massy, B_.
Le Mée, G., Ezzeddine, N., Capri, M., Aït-Ahmed, O.
Svetlanov A, Baudat F, Cohen PE, de Massy B.
Buard, J., De Massy, B.
Chicheportiche A, Bernardino-Sgherri J, de Massy B, Dutrillaux B.
Baudat, F., de Massy, B
Baudat, F., de Massy, B.
Cosson, B., Gautier-Courteille, C., Maniey, D., Ait-Ahmed, O., Lesimple, M., Osborne, H.B., Paillard, L.
Bérard S., Buard J. et E. Rivals.
Guillon, H., Baudat, F., Grey, C., Liskay, R.M. and de Massy, B
Alkan, C., Tuzun, E., Buard, J., Lethiec, F., Eichler, EE., Bailey JA., Sahinalp, SC.
Guettier, C., Sebagh, M., Buard, J., Feneux, D., Ortin-Serrano, M., Gigou, M., Tricottet, V., Reynes, M., Samuel, D., Feray, C.
Delaunay J, Le Mée G, Ezzeddine N, Labesse G, Terzian C, Capri M, Aït-Ahmed O.
Laurent, A. M., Li, M., Sherman, S., Roizes, G., Buard, J.,
de Massy, B.
Ezzeddine, N., Paillard, L., Capri, M., Maniey, D., Bassez, T., Aït-Ahmed, O. and Osborne, H.B.
Lopes J., Debrauwere H., Buard J., Nicolas A.
Buard J., Brenner C., Jeffreys A.J.
Guillon H. and de Massy B.
Metzler-Guillemain, C. et de Massy B.
Buard J., Collick A., Brown J. and Jeffreys, A.J.
Buard, J., Shone, A.C. and Jeffreys, A.J.
Debrauwere H., Nicolas A., Vergnaud G., Buard J., Tessier J. et Aubert D.
Stead JD, Buard J, Todd JA, Jeffreys AJ.
Gangloff, S., De Massy, B., Lane, A., Rothstein, R. and Fabre, F.
Debrauwere H, Buard J, Tessier J, Aubert D, Vergnaud G, Nicolas A.
Capri, M., Santoni, M.J., Thomas-Delaage, M. and Aït-Ahmed, O.
Dardhalon, M., De Massy, B., Nicolas, A. and Averbeck, D.
Santoni, M.J., Aït-Ahmed, O. and Marilley, M.
Doyen CM1, Chalkley GE1, Voets O1, Bezstarosti K2, Demmers JA2, Moshkin YM1, Verrijzer CP3.
2015 - Cell Rep
, 13, 7, 1310-1318 26549447
Service porteur :
Laboratory of Molecular Virology
Rahmoun M, Perez J, Saunders PA, Boizet-Bonhoure B, Wilhelm D, Poulat F, Veyrunes F.
2014 - Sex Dev.
, 8, 6, 356-363 25359508
Service porteur :
Development and Pathology of the gonad
Psomas C, Lavigne JP, Barbuat C, Trabelsi S, Ghosn J, Lascoux-Combe C, Flandre P, Cuzin L, Reynes J, Autran B, Corbeau P.
2013 - Blood
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Service porteur :
Homing, immune activation and infection
Lutzmann M, Grey C, Traver S, Ganier O, Maya-Mendoza A, Ranisavljevic N, Bernex F, Nishiyama A, Montel N, Gavois E, Forichon L, de Massy B, Méchali M.
2012 - Mol. Cell
, 47, 4, 523-534 22771120
Service porteur :
Replication and Genome Dynamics
Lemaitre, JM., Bocquet, S., Terret, ME., Namdar, M., Ait-Ahmed, O., Kearsey, S., Verlhac, MH., and Méchali, M.
2004 - Mol Reprod Dev.
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Service porteur :
Replication and Genome Dynamics