Régulation des gènes

Dynamique du génome

All organisms must regulate the expression of their genes to achieve the silencing of certain genes, and the activation of others during development and homeostasis. Disregulation of gene expression frequently has dire consequences, and can lead to pathologies such as cancer. The regulation of gene expression occurs at different levels, all of which depend on a multitude of factors. Chromatin is a primary regulator of gene expression. Physical compaction of the genome into chromatin controls accessability to the transcription machinery. Studies performed over recent years have revealed the enormous complexity involved in modifying chromatin to regulate gene expression.

Rosemary KIERNAN
Chercheur

0434359935
Julie Bossuyt
Julie BOSSUYT
Ingénieur d'études en biologie moléculaire
IT

0434359935
Marina Srbic
Marina SRBIC
IT

0434359935
Charbel AKKAWI
Postdoc

0434359935

Publications de l'équipe

Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression

Kalina Timcheva, Solenne Dufour, Leila Touat-Todeschini, Callum Burnard, Marie-Christine Carpentier, Florent Chuffart, Rémy Merret, Marion Helsmoortel, Sabrina Ferré, Aude Grézy, Yohann Couté, Sophie Rousseau, Saadi Khochbin, Claire Vourc’h, Cécile Bousquet-Antonelli, Rosemary Kiernan, Daphné Seigneurin-Berny and André Verdel

lire la publication

en savoir plus

The Polyvalent Role of NF90 in RNA Biology

Giuseppa Grasso and Rosemary Kiernan

en savoir plus

NF90 interacts with components of RISC and modulates association of Ago2 with mRNA.

Grasso G*, Akkawi C*, Franckhauser C, Nait-Saidi R, Bello M, Barbier J, Kiernan R

NF90 Interacts with Components of RISC and Modulates Association of Ago2 with mRNA

Giuseppa Grasso, Charbel Akkawi, Celine Franckhauser, Rima Nait-Saidi, Maxime Bello, Jérôme Barbier, Rosemary Kiernan

en savoir plus

Chromatin-associated MRN complex protects highly transcribing genes from genomic instability

Kader Salifou, Callum Burnard, Poornima Basavarajaiah, Marion Helsmoortel, Victor Mac, David Depierre, Giuseppa Grasso, Céline Franckhauser, Emmanuelle Beyne, Xavier Contreras, Jérôme Dejardin, Sylvie Rouquier, Olivier Cuvier, Rosemary Kiernan

en savoir plus

PAF1 facilitates RNA polymerase II ubiquitination by the Elongin A complex through phosphorylation by CDK12

Gabriel Sanchez, Jérôme Barbier, Céline Elie, Rosemary Kiernan, Sylvie Rouquier

en savoir plus

NF90 modulates processing of a subset of human pri-miRNAs

Grasso G, Higuchi T, Mac V, Barbier J, Helsmoortel M, Lorenzo C, Sanchez G, Bello M, Ritchie W, Sakamoto S, and Kiernan R.

en savoir plus

[Nuclear RNA surveillance complexes control HIV-1 transcription].

Salifou K, Kiernan R, Contreras X

An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression.

Barbier J, Chen X, Sanchez G, Cai M, Helsmoortel M, Higuchi T, Giraud P, Contreras X, Yuan G, Feng Z, Nait-Saidi R, Deas O, Bluy L, Judde JG, Rouquier S, Ritchie W, Sakamoto S, Xie D, Kiernan R

+ Intelligence artificielle et régulation génique

Nuclear RNA surveillance complexes silence HIV-1 transcription.

Contreras X, Salifou K, Sanchez G, Helsmoortel M, Beyne E, Bluy L, Pelletier S, Rousset E, Rouquier S, Kiernan R

Identification of histone 3 variant 2 interacting factors

Latreille D, Bluy L, Benkirane M, Kiernan RE.

+ Virologie Moléculaire

Premature termination of transcription by RNAP II: The beginning of the end.

Contreras X, Benkirane M, Kiernan R.

+ Virologie Moléculaire

Microprocessor, Setx, Xrn2 and Rrp6 Co-Operate to Induce Premature Termination of Transcription by RNAPII

Wagschal, A., Rousset, E., Basavarajaiah, P., Contreras, X. , Harwig, A., Laurent-Chabalier, S. , Nakamura, M., Chen, X., Zhang, K., Meziane, O., Boyer, F., Parrinello, H., Berkhout, B., Terzian, C., Benkirane, M., Kiernan, R.

+ Virologie Moléculaire

Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR

Nakamura M, Basavarajaiah P, Rousset E, Beraud C, Latreille D, Henaoui IS, Lassot I, Mari B, Kiernan R.

HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP

Sobhian, B., Laguette, N., Yatim, A., Nakamura, M., Levy, Y., Kiernan, R., Benkirane, M.


+ Virologie Moléculaire

Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post integration latency.

du Chéné, I., Basyuk, E., Lin,YL., Triboulet, R., Knezevich, A., Chable-Bessia, C., Mettling, C., Baillat, V., Reynes, J., Corbeau, P., Bertrand, E., Marcello, A., Emiliani, S., Kiernan, R., Benkirane, M.


+ Virologie Moléculaire

Intrinsic ubiquitylation activity of PCAF controls the stability of the oncoprotein Hdm2

Linares, Laetitia, Rosemary Kiernan, Robinson Triboulet, Christine Chable-Bessia, Daniel Latreille, Olivier Cuvier, Matthieu Lacroix, Laurent Le Cam, Olivier Coux, and Monsef Benkirane.


+ Virologie Moléculaire

The Proteasome Regulates HIV-1 Transcription by Both Proteolytic and Non-Proteolytic Mechanisms

Lassot, L., Latreille, D., Rousset, E., Sourisseau, M., Linares, L.K., Chable-Bessia, C., Coux, O., Benkirane, M., Kiernan, R.


+ Virologie Moléculaire

The HIV-1 Tat protein stimulates reverse transcription in vitro.

Apolloni, A., Meredith, LW., Suhrbier, A., Kiernan, R., Harrich, D


+ Virologie Moléculaire

Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter.

Treand C, du Chene I, Bres V, Kiernan R, Benarous R, Benkirane M, Emiliani S.


+ Virologie Moléculaire

A non proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

Vanessa Brès, Rosemary E. Kiernan, Laetitia K. Linares, Christine Chable-Bessia, Olga Plechakova, Céline Tréand, Stephane Emiliani, Jean-Marie Peloponese, Kuan-Teh Jeang, Olivier Coux, Martin Scheffner, and Monsef Benkirane


+ Virologie Moléculaire

Tat acetyl-acceptor lysines are important for Human Immunodeficiency Virus type-1 replication

Brès, V., Rosemary Kiernan, Stéphane Emiliani and Monsef Benkirane


+ Virologie Moléculaire

Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF.

Brès V. Tagami H. Péloponèse J.M. Loret E. Jeang K-T. Nakatani Y. Emiliani S. Benkirane M. and Kiernan ER.


+ Virologie Moléculaire

Interaction between cyclin T1 and SCFSKP2 targets CDK9 for ubiquitination and degradation by the proteasome.

Kiernan, R., Emiliani, S., Nakayama, K., Castro, A., Labbé, J.C., Lorca, T., Nakayama, K.-I., and Benkirane, M.


+ Virologie Moléculaire

HIV-1 Tat transcriptional activity is regulated by acetylation.

Kiernan, R., Vanhulle, C., Schiltz, L., Adam, E., Xiao, H., Maudoux, F., Calomme, C., Burny, A., Nakatani, Y., Jeang, K.-T., Benkirane, M. and Van Lint, C.


+ Virologie Moléculaire

CONTRERAS Xavier
CONTRERAS Xavier
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HELSMOORTEL Marion
HELSMOORTEL Marion
BioAster
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BARBIER Jérôme
BARBIER Jérôme
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SANCHEZ Gabriel
SANCHEZ Gabriel
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SALIFOU Kader
SALIFOU Kader
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GIRAUD Pierre
GIRAUD Pierre
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FUKUHARA Mitsuko
FUKUHARA Mitsuko
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MURGUET Vivien
MURGUET Vivien
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BEYNE Emmanuelle
BEYNE Emmanuelle
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NOGARET Maguelone
NOGARET Maguelone
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GRASSO Giuseppa
GRASSO Giuseppa
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BELLO Maxime
BELLO Maxime
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CROISET Mia
CROISET Mia
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TANCELIN Mathilde
TANCELIN Mathilde
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BERAUD Cyprien
BERAUD Cyprien
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HAMED-LEBENE Sarah
HAMED-LEBENE Sarah
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ASTIER William
ASTIER William
Ecole Polytechnique Fédérale de Lausanne (EPFL), Suisse
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NAKAMURA Mirai
NAKAMURA Mirai
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ROUSSET-CARLAC Emilie
ROUSSET-CARLAC Emilie
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BASAVARAJAIAH Poornima
BASAVARAJAIAH Poornima
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ATTIK Yohan
ATTIK Yohan
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COLENO-COSTES Anne
COLENO-COSTES Anne
IGMM CNRS
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CRUNCHANT Eleonore
CRUNCHANT Eleonore
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PELLETIER Stéphane
PELLETIER Stéphane
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KLEIN Brice
KLEIN Brice
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BILGIC Merve
BILGIC Merve
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PHAM  Vu anh quan
PHAM Vu anh quan
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ZOGHLAMI Rayan
ZOGHLAMI Rayan
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VERLEENE Fantine
VERLEENE Fantine
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LE HARS Matthieu
LE HARS Matthieu
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#}