Speaker:
Matthias Altmeyer
Amphitheater of Genopolys
Dynamics and Functions of DNA Repair Compartments
Our research interest is to understand how human cells deal with genotoxic stress assaults and how they coordinate genome maintenance mechanisms with other vital cellular functions. To this end we combine state-of-the-art molecular biology and biochemistry with powerful advanced cell imaging technologies, in particular employing single cell chromatin perturbations, high resolution live cell imaging, automated quantitative microscopy and software-assisted image analysis. By targeted ablation of specific...
Speaker:
Dr. Nitzan Gonen
Amphitheater of genopolys
The Battle of Sexes: Studying the Gene Regulatory Networks of Mammalian Sex Determination.
Sex Determination is the process by which an organism develops into either male or female. A main research interest of our lab is to understand, at the molecular level, how sex is determined during embryonic development.
In mammals, sex determination is genetically driven with XY individuals developing as males and XX individuals developing as females. Problems in this process lead to a large group of developmental disorders classified as Disorders of Sex Development (DSD), with...
Speaker:
Max Greenberg (Institut Jacques Monod, CNRS, Université Paris Cité, Paris, France)
IGH Seminar room 1st floor
Non-canonical functions of DNA methylation during epigenetic reprogramming in mammals
Immediately after fertilization, mammalian embryos undergo a dramatic reshaping of the epigenome as the embryo transitions from the zygote into the pluripotent cells primed for lineage commitment. This is best exemplified by 5-cytosine DNA methylation (5meC) reprogramming, as the gametic patterns are largely erased, and the embryonic genome undergoes a wave of de novo DNA methylation. Moreover, once 5meC patterns are established, mechanisms faithfully maintain the mark across cell division. Thus,...
Epigenetics workshop-Seminar Serie 7th-15th Nov 2022
The Nuclear architecture in physiology - Charlène Boumendil - and the Chromatin and cell biology - Giacomo CAVALLI - are thrilled to announce our next workshop in Epigenetics, from November 07th to November 15th.
We have a fantastic speakers line up (see below and attached flyer), all seminars will take place at 2pm in the Genopolys Amphitheatre.
7th Nov, 2pm: Dr Petra Hajkova, MRC London Institute of Medical Sciences - UK
Stability and erasure of epigenetic information in vivo and in vitro
8th Nov,...
Speaker:
Dr. Mireille Betermier (Director of research at CNRS- Institute for Integrative Biology of the Cell, Department of Genome Biology Université Paris-Saclay)
Amphitheater of Genopolys
Programmed DNA elimination in the ciliate Paramecium: from molecular mechanism to evolution
With its nuclear dimorphism, the ciliate Paramecium provides a powerful unicellular model to study how eukaryotic genomes cope with transposable elements (TEs). During evolution, the Paramecium germline genome, hosted in two transcriptionally silent micronuclei, has been continuously colonized by TEs, including in essential coding regions. Functional gene expression relies on the programmed elimination of parasitic sequences, which takes place at each sexual cycle in the transcription-prone somatic...
