DNA N6-adenine methylation (6mA) is rediscovered as an important epigenetic mark in eukaryotes. It however remains unclear what the de novo methyltransferases (MTases) are and how they fulfill their biological functions. The binucleated Tetrahymena thermophila happens to possess a unique time window for the study of de novo methylation, when the 6mA-free zygotic nucleus develops into 6mA-positive new macronucleus (MAC). In this study, we found that the MT-A70 family members, AMT2 and AMT5, are not required for the maintenance 6mA in the vegetative MAC but for de novo 6mA in the new MAC. As a consequence loss of AMT2 and/or AMT5 reduces the fitness of sexual progeny.
de novo methylation of N6-methyladenine (6mA) showcased in the unicellular eukaryote Tetrahymena Epigenetic Chromatin Regulation
ORGANIZED BY IGH
International Summer-School on Epigenetics from 15/07/2024 until 19/07/2024 Genopolys, Montpellier - France
Meiosis and recombinationMBHD Dpt. Seminar Series
IGH Seminar Series of the Department “Molecular basis of Human Diseases” from 02/04/2024 until 11/10/2024 11:30 - 14:00 Genopolys amphitheater
GCB&D Dpt. Seminar Series
IGH Seminar Series of the Department “Genetics, Cell Biology and Development” from 19/02/2024 until 15/11/2024 Genopolys amphitheater
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Selective autophagy of DNA lesions promotes DNA repair and cell survival
11/10/2024 11:30 Genopolys AmphitheatreIchthyosporeans and the evolution of animal embryogenesis
15/11/2024 11:30 Genopolys amphitheaterCongresses
Transcription and Genome maintenance
09/09/2024 until 13/09/2024 Roscoff, France2024 RNase H meeting
16/09/2024 until 18/09/2024 Engelthal Ingelheim, GermanyCBS2 day 2024
26/09/2024 Université Montpellier, FrTweet