Projects Team Maintenance of genome integrity during DNA replication

The integrity of the genetic information stored in DNA is constantly challenged by various types of DNA lesions. DNA topoisomerase I (Top1) has been[...]

Transcription and replication occur on the same DNA strand and the transcription process is one of the main source of obstacles for the replication[...]

Chemotherapy is still the standard treatment for a wide range of cancers despite the frequent emergence of chemotherapy[...]