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IGH Intranet
Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
Cell Reports 2024
Genetic Instability and Cancer
Chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms
Development 2023
Neurogenetics and memory
A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation.
Sci Adv 2023
Tubulin code
Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
Molecular Cell 2023
Genetic Instability and Cancer
PAPγ associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs
Nature Communications 2023
Gene regulation
POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape from innate immune sensing
Science Advances 2023
Laboratory of Molecular Virology
Transposable elements acquire time-and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development
Front. Cell Dev. Biol. 2024
Development and Pathology of the gonad
RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart
The EMBO Journal 2023
Maintenance of genome integrity during DNA replication
Two redundant transcription factor binding sites in a single enhancer are essential for mammalian sex determination
Nucleic Acids Res 2024
Development and Pathology of the gonad
Transient loss of Polycomb components induces an epigenetic cancer fate.
Nature 2024
Chromatin and cell biology
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The Institute of Human Genetics is dedicated to excellence in fundamental research and pathology. The principal research interests of the IGH are genome dynamics, developmental genetics, epigenetics, and molecular and cellular pathology
3
DEPARTMENTS
26
RESEARCH TEAMS
1496
PUBLICATIONS
12
ERC LAUREATES
(7 Adv, 2 StG, 2 COG & 1PoC)
55
PHD THESES AND HDR DEFENCES
Headlines
Cavalli & Dejardin chairs of excellence winners
Ali received the 1st prize in the regional 3MT
In Memoriam - Angelos Constantinou
Research departments
Molecular Bases of Human Diseases
High quality research in the fields of immunology and cancer
Genome Dynamics
Research on understanding the multiple activities of the genome in various model systems
Genetics, Cell Biology and Development
Understand genetic information translated into the production of many different cell types
Last publications
All publications
Integrative single-cell chromatin and transcriptome...
Blood 2024
Epigenome modifications and genomic instability in normal and malignant B cells
Long-term results of Waldenström macroglobulinaemia...
Br J Haematol 2024
Epigenome modifications and genomic instability in normal and malignant B cells
An atlas of cells in the human tonsil....
Immunity 2024
Epigenome modifications and genomic instability in normal and malignant B cells
A SUMO E3 ligase promotes long non-coding RNA transcription...
Elife 2024
Epigenetic Chromatin Regulation
Combined inhibition of Wee1 and Chk1 as a therapeutic...
Front Oncol 2023
Epigenome modifications and genomic instability in normal and malignant B cells
Mutation hotspots during meiosis...
Science 2023
Meiosis and recombination
Immunophenotypic portrait of leukemia-associated-phenotype...
Cytometry B Clin Cytom 2023
Epigenome modifications and genomic instability in normal and malignant B cells
RNA-sequencing based first choice of treatment and...
Front Immunol 2023
Epigenome modifications and genomic instability in normal and malignant B cells
Extreme thrombocytosis with an aggressive evolution...
Eur J Haematol 2023
Epigenome modifications and genomic instability in normal and malignant B cells
Metazoan nuclear pore complexes in gene regulation...
DNA Repair (Amst) 2023
Nuclear architecture in physiology and pathology
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ORGANIZED BY IGH
International Summer-School on Epigenetics
from 15/07/2024 until 19/07/2024
Genopolys, Montpellier - France
Meiosis and recombination
MBHD Dpt. Seminar Series
IGH Seminar Series of the Department “Molecular basis of Human Diseases”
from 02/04/2024 until 11/10/2024 11:30 - 14:00
Genopolys amphitheater
GCB&D Dpt. Seminar Series
IGH Seminar Series of the Department “Genetics, Cell Biology and Development”
from 19/02/2024 until 15/11/2024
Genopolys amphitheater
Seminars
BRCA2 interactome in meiosis and mitosis: the role of intrinsically disordered regions
26/04/2024 10:00 Genopolys, Montpellier - France
Mechanisms of genome stability maintenance during cell division
26/04/2024 11:00 Genopolys, Montpellier - France
All seminars
Congresses
Chromatin, Epigenetics & Transcription
13/05/2024 until 17/05/2024 Suzhou, China
International Summer-School on Epigenetics
Meiosis and recombination
15/07/2024 until 19/07/2024 Genopolys, Montpellier - France
Transcription and Genome maintenance
09/09/2024 until 13/09/2024 Roscoff, France
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