Speaker:
Pengyi YANG (University of Sydney, Australia)
IGH seminar room
Computational methods for stem cell biology and engineering
Computational methods are essential for characterising molecular programs that control cell-identity and stem cell-fate decisions. In this seminar, I will present our research on developing and applying computational methods for studying stem cells and stem cell-derived organoids. This will be followed by some initial results from using this knowledge and methodologies for cellular conversion and cell-fate engineering, a key foundation for tissue engineering, disease modelling, and regenerative medicine.
Speaker:
Carissa CHEN (University of Sydney, Australia)
IGH seminar room
Computational systems approaches to spatial and multi-omics analysis of tissues and organoid models
Defining the molecular networks orchestrating human brain formation is crucial for understanding neurodevelopment and neurological disorders. In the first part of my talk, I will present my research work on elucidating the molecular programs that drive this highly dynamic process by reconstructing molecular networks that control human cerebral organoids formation using trans-omics data. Next, I will focus on spatial transcriptomics data analysis and present our findings on comparing methods for detecting...
Immune cells in the choreography of cerebral development
Neurobiologist Sonia GAREL, Professor at the Collège de France and Member of the Academy of Sciences, has led the « Brain Development and Plasticity team » at the ENS Institute of Biology (IBENS) since 2008. Sonia Garel is a pioneer in the study of the mechanisms that control the assembly of forebrain neural circuits during embryogenesis and postnatal development. Her fascinating research shows that brain activity is regulated by immune cells, called “microglia” that play a key role in neurodegenerative...
Speaker:
John Diffley (Crick Institute, Londres)
Genopolys Amphitheatre
DNA Replication Forks and the DNA Damage Checkpoint
On Tuesday, June 4th, Genopolys Amphitheater, at 11h30, John Diffley (Crick Institute, London) will give an exciting seminar on DNA damage and replication titled “DNA Replication Forks and the DNA Damage Checkpoint.”
John Diffley, the Associate Director of the Francis Crick Institute, London, is a pioneer in the field of DNA replication and DNA damage. His groundbreaking research involves characterizing the mechanisms of DNA replication and has provided unparalleled insights into the initiation...
Topologically Associating Domains regulate gene activity by restricting enhancer-promoter loops.
Topologically Associating Domains regulate gene activity by restricting enhancer-promoter loops. TADs are formed by loop extrusion and its blocking by CTCF at their boundaries. How optimal separation between TADs is achieved remains incompletely understood.
I will present our recent work showing that most TAD boundaries consist of clustered CTCF sites, with each site imperfectly and additively contributing to loop extrusion blocking. Moreover, I will present unpublished biophysical modeling and...
