Projects Team Genome Surveillance and Stability

It has been known for a longtime that the DDR is inefficient in the early embryos, however the reasons for this regulation and the underlying molecular[...]

We have shown that ectopic expression of Rad18 in human somatic cells is sufficient to constitutively activate translesion DNA synthesis and shut down[...]

In the aim of identifying new DDR-responsive genes, we have developped an in vitro screen using protein extracts derived from Xenopus eggs and identified[...]