Project : Chromatinian control of inflammatory responses

Although most immunogenic nucleic acids are detected in the cytosol, the proteins mediating this recognition are, to a large extent, associated with chromatin when inactive. This for example the case of the cGAS protein, central to the detection of nucleic acids in the cytosol. Our recent work shows that the cytosolic presence of immunogenic nucleic acids leads to the mobilization of numerous chromatinian proteins. We study the consequences of cytosolic mobilization of nuclear proteins and their impact on the regulation of inflammatory responses.