Project : Inflammation and metabolism

Chronic inflammation can be fueled by high fat diets that promote concerted alterations of inflammatory and metabolic pathways. We recently identified the STING protein, central to the production of type I Interferons in the presnece of cytosolic nucleic acids, as a central regulator of polyunsaturated fatty acid metabolism. We are exploring the communication between these inflammatory and metabolic pathways, at the cellular, tissue and body levels, to reveal their impact on the maintenance of homeostasis and in chronic inflammatory pathologies (Vila et al. https://www.biorxiv.org/content/10.1101/2020.12.22.423950v1.)