Computational systems approaches to spatial and multi-omics analysis of tissues and organoid models Biology of distal regulatory elements

Defining the molecular networks orchestrating human brain formation is crucial for understanding neurodevelopment and neurological disorders. In the first part of my talk, I will present my research work on elucidating the molecular programs that drive this highly dynamic process by reconstructing molecular networks that control human cerebral organoids formation using trans-omics data. Next, I will focus on spatial transcriptomics data analysis and present our findings on comparing methods for detecting spatially variable gene (SVGs). Our study highlights the discrepancies among different methods and potential impact they may have on downstream analysis of spatial transcriptomics data.