Project : To explore the molecular mechanisms of oculopharyngeal muscular dystrophy (OPMD) using the Drosophila model

We are addressing the role of small RNAs and ribosomal RNAs in OPMD, as well as the role of cellular stresses.

We are also using our Drosophila OPMD model to identify molecules that might have a strong potential for future treatments.

Figure : Role of polyadenylation and deadenylation in OPMD (Chartier et al. PLOS Genetics 2015).