There has been tremendous progress in the past few years regarding our understanding of DNA replication in eukaryotes, both yeast and mammals. Many important questions in the field are poised to be answered within the next decade. These include understanding DNA replication at the biochemical and three-dimensional protein structure levels. In addition, studies using high throughput technologies at the cellular and organismal levels are poised to answer how accurate replication of the genome is ensured by controlling origin firing in space and time.
Session topics
- Replisome structure
- Origin selection, licensing and firing
- Chromatin replication
- Replication stress and fork stability
- Replication in cancer – etiology and treatment opportunities
