A Deep Learning approach to challenge live imaging of EndoMAMs (endosomal membranes associated with mitochondria)
Jean Salamero is an internationally renowned expert in imaging. He led a team at Curie for many years, working on endomembrane trafficking and developping various live, fixed and correlative imaging methods. In addition to his research acitivities, Jean played a major role to develop imaging infrastructures nationwide. He created and developped the Curie imaging facility, he was also a key player for the creation of France-BioImaging and later led this National Infrastructure dedicated to biological...
Virginie Courtier-Orgogozo is a research director at the CNRS, she leads a team at the Institut Jacques Monod in Paris (https://courtier.ijm.fr/), she is an invited professor at the Collège de France (https://www.college-de-france.fr/fr/chaire/virginie-courtier-orgogozo-biodiversite-et-ecosystemes-chaire-annuelle/)
Nick started his career as a PhD student in the biochemistry department at Edinburgh University, and continued his training as a postdoc with Professor Wendy Bickmore. He started his lab in the Edinburgh Cancer Research Centre in 2006 with a fellowship from the Wellcome Trust and moved to the Human Genetics Unit in 2012 funded by an MRC Senior Fellowship. Nick is currently an MRC Investigator and holds a Wellcome Investigator award.
Orateur:
Pengyi YANG (University of Sydney, Australia)
IGH seminar room
Computational methods for stem cell biology and engineering
Computational methods are essential for characterising molecular programs that control cell-identity and stem cell-fate decisions. In this seminar, I will present our research on developing and applying computational methods for studying stem cells and stem cell-derived organoids. This will be followed by some initial results from using this knowledge and methodologies for cellular conversion and cell-fate engineering, a key foundation for tissue engineering, disease modelling, and regenerative medicine.
Orateur:
Carissa CHEN (University of Sydney, Australia)
IGH seminar room
Computational systems approaches to spatial and multi-omics analysis of tissues and organoid models
Defining the molecular networks orchestrating human brain formation is crucial for understanding neurodevelopment and neurological disorders. In the first part of my talk, I will present my research work on elucidating the molecular programs that drive this highly dynamic process by reconstructing molecular networks that control human cerebral organoids formation using trans-omics data. Next, I will focus on spatial transcriptomics data analysis and present our findings on comparing methods for detecting...