Chromatine et Biologie Cellulaire

Dynamique du génome

Le génome est plus qu'une suite linéaire de gènes. Il est compacté dans l’espace tridimensionnel du noyau cellulaire en structures tertiaires et quaternaires d'ordre supérieur. Les gènes flanquants s'organisent dans des domaines chromosomiques qui sont caractérisés par de types différents de chromatine, actifs ou répressifs.
Dans l'espace 3D, chaque site à l’intérieur d’un domaine contacte les autres sites à l’intérieur du domaine plus fréquemment que les sites d’autres domaines.
Cette propriété permet de définir les domaines physiques ou topologiquement associés (TAD). Au niveau du chromosome, les TAD individuels forment des contacts avec d'autres TAD, préférentiellement du même type, afin de construire des architectures 3D ordonnées appelées territoires chromosomiques. Enfin, différents chromosomes s'organisent de manière non aléatoire dans l'espace nucléaire.
Par conséquent, le génome eucaryote est hautement organisé en 3D et cette régulation peut être transmise ou modulée pendant la vie des cellules et des organismes. Cette chorégraphie chromosomique sophistiquée implique des milliers de différents acteurs - séquences d'ADN, ARNs et protéines - mais plutôt que de se combiner en un nombre infini de formes, ces composantes organisent un nombre relativement limité de types de chromatine, soit actifs, soit répressifs.
En particulier, deux groupes principaux de facteurs régulateurs du génome sont constitués par les protéines Polycomb (PcG) et Trithorax (trxG). Les protéines PcG maintiennent la mémoire des états silencieux de l'expression de gènes à travers la physiologie cellulaire et les divisions cellulaires multiples, tandis que les membres du trxG maintiennent des états actifs de la chromatine.
Ces protéines sont capables de reconnaître les états chromatiniens de leurs gènes cibles et de maintenir ces états au fil des divisions cellulaires même après la disparition des régulateurs transcriptionnels qui les ont induits en premier lieu. Remarquablement, ces états peuvent également être transmis à une fraction de la descendance au cours de plusieurs générations.
Dans notre laboratoire, nous visons à comprendre le principe régissant l'organisation du génome en 3D, ses implications fonctionnelles et les mécanismes moléculaires par lesquels les protéines PcG et trxG régulent leurs gènes cibles, transmettent l'héritage des états chromatiniens et orchestrent le développement.
Pour atteindre cet objectif, nous utilisons une variété d'approches et de techniques complémentaires dans les domaines de la biologie moléculaire, cellulaire et de développement, de la génomique et de la bioinformatique.

Frederic BANTIGNIES
Responsable de Projet
Chercheur

0434359997
Giacomo CAVALLI
Chercheur

0434359970
Thierry CHEUTIN
Chercheur

0434359997
Cristina Fracassi
Cristina FRACASSI
Chercheur

0434359968
Anne-Marie MARTINEZ
Responsable de Projet
Chercheur

0434359969
Flora Paldi
Flora PALDI
Chercheur

0434359968
Gonzalo SABARIS
Chercheur

0434359968
Bernd SCHUTTENGRUBER
Chercheur

0434359997
Nazli AKILLI
Doctorant

0434359997
Ana-Maria Popmihaylova
Ana-Maria POPMIHAYLOVA
Doctorant

0434359968
Hadrien Reboul
Hadrien REBOUL
Doctorant

0434359997
Solène Dufau
Solène DUFAU
ITA

0434359997
Lauriane FRITSCH
ITA

0434359968
Davide NORMANNO
ITA

0434359662
Juliette Gracia
Juliette GRACIA
Stagiaire

0434359997
Mona Mazouzi
Mona MAZOUZI
Stagiaire

0411759728
Patrick Allard
Patrick ALLARD
Accueil Scientifique

0411759728

Publications de l'équipe

Phase separation and inheritance of repressive chromatin domains.

Akilli N, Cheutin T, Cavalli G

Drosophila TET acts with PRC1 to activate gene expression independently of its catalytic activity.

Gilbert G, Renaud Y, Teste C, Anglaret N, Bertrand R, Hoehn S, Jurkowski TP, Schuettengruber B, Cavalli G, Waltzer L, Vandel L

Multiplexed chromatin imaging reveals predominantly pairwise long-range coordination between Drosophila Polycomb genes.

Gurgo J, Walter JC, Fiche JB, Houbron C, Schaeffer M, Cavalli G, Bantignies F, Nollmann M

en savoir plus

Transient loss of Polycomb components induces an epigenetic cancer fate.

Parreno V, Loubiere V, Schuettengruber B, Fritsch L, Rawal CC, Erokhin M, Győrffy B, Normanno D, Di Stefano M, Moreaux J, Butova NL, Chiolo I, Chetverina D, Martinez AM, Cavalli G

The Density of Regulatory Information Is a Major Determinant of Evolutionary Constraint on Noncoding DNA in Drosophila.

Sabarís G, Ortíz DM, Laiker I, Mayansky I, Naik S, Cavalli G, Stern DL, Preger-Ben Noon E, Frankel N

en savoir plus

Editorial overview: Multiscale regulation of genome folding in space, time, and across the tree of life.

Cavalli G, Dekker J

en savoir plus

Epigenetic inheritance in adaptive evolution.

Sabarís G, Fitz-James MH, Cavalli G

Topological screen identifies hundreds of Cp190- and CTCF-dependent Drosophila chromatin insulator elements.

Kahn TG, Savitsky M, Kuong C, Jacquier C, Cavalli G, Chang JM, Schwartz YB

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Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.

Ringel AR, Szabo Q, Chiariello AM, Chudzik K, Schöpflin R, Rothe P, Mattei AL, Zehnder T, Harnett D, Laupert V, Bianco S, Hetzel S, Glaser J, Phan MHQ, Schindler M, Ibrahim DM, Paliou C, Esposito A, Prada-Medina CA, Haas SA, Giere P, Vingron M, Wittler L, Meissner A, Nicodemi M, Cavalli G, Bantignies F, Mundlos S, Robson MI

A shared ancient enhancer element differentially regulates the bric-a-brac tandem gene duplicates in the developing Drosophila leg.

Bourbon HG, Benetah MH, Guillou E, Mojica-Vazquez LH, Baanannou A, Bernat-Fabre S, Loubiere V, Bantignies F, Cavalli G, Boube M

Comprehensive characterization of the epigenetic landscape in Multiple Myeloma.

Alaterre E, Ovejero S, Herviou L, de Boussac H, Papadopoulos G, Kulis M, Boireau S, Robert N, Requirand G, Bruyer A, Cartron G, Vincent L, Martinez AM, Martin-Subero JI, Cavalli G, Moreaux J

HiCmapTools: a tool to access HiC contact maps.

Chang JM, Weng YF, Chang WT, Lin FA, Cavalli G

SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers.

Barral A, Pozo G, Ducrot L, Papadopoulos GL, Sauzet S, Oldfield AJ, Cavalli G, Déjardin J

Mechanisms of Polycomb group protein function in cancer.

Parreno V, Martinez AM, Cavalli G

Molecular mechanisms of transgenerational epigenetic inheritance.

Fitz-James MH, Cavalli G

Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types.

Erokhin M, Chetverina O, Győrffy B, Tatarskiy VV, Mogila V, Shtil AA, Roninson IB, Moreaux J, Georgiev P, Cavalli G, Chetverina D

Understanding 3D genome organization by multidisciplinary methods

Ivana Jerkovic´ & Giacomo Cavalli

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en savoir plus

test

test1, test2

Regulation of single-cell genome organization into TADs and chromatin nanodomains

Szabo Q., Donjon A., Jerkovic I., Papadopoulos G.L., Cheutin T., Bonev B., Nora E., Bruneau B.G., Bantignies F., Cavalli, G.

en savoir plus

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

Sati S., Bonev, B., Szabo, Q., Jost, D., Bensadoun, P., Serra, F., Loubiere

en savoir plus

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping.

Loubiere V, Papadopoulos GL, Szabo Q, Martinez AM, Cavalli G


+ Chromatine et Biologie Cellulaire

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping.

Loubiere V, Papadopoulos GL, Szabo Q, Martinez AM, Cavalli G


+ Chromatine et Biologie Cellulaire

Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

Pal K, Forcato M, Jost D, Sexton T, Vaillant C, Salviato E, Mazza EMC, Lugli E, Cavalli G, Ferrari F


+ Chromatine et Biologie Cellulaire

en savoir plus

Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

Pal K, Forcato M, Jost D, Sexton T, Vaillant C, Salviato E, Mazza EMC, Lugli E, Cavalli G, Ferrari F


+ Chromatine et Biologie Cellulaire

en savoir plus

Advances in epigenetics link genetics to the environment and disease

Giacomo Cavalli and Edith Heard


+ Chromatine et Biologie Cellulaire

Advances in epigenetics link genetics to the environment and disease

Giacomo Cavalli and Edith Heard


+ Chromatine et Biologie Cellulaire

Principles of genome folding into topologically associating domains.

Szabo Q, Bantignies F, Cavalli G

Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms.

Cardozo Gizzi AM, Cattoni DI, Fiche JB, Espinola SM, Gurgo J, Messina O, Houbron C, Ogiyama Y, Papadopoulos GL, Cavalli G, Lagha M, Nollmann M

Cell Fate and Developmental Regulation Dynamics by Polycomb Proteins and 3D Genome Architecture.

Loubiere V, Martinez AM, Cavalli G

PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs.

Herviou L, Kassambara A, Boireau S, Robert N, Requirand G, Müller-Tidow C, Vincent L, Seckinger A, Goldschmidt H, Cartron G, Hose D, Cavalli G, Moreaux J


+ Maintien de l'intégrité du génome au cours de la réplication

Challenges and guidelines toward 4D nucleome data and model standards.

Marti-Renom MA, Almouzni G, Bickmore WA, Bystricky K, Cavalli G, Fraser P, Gasser SM, Giorgetti L, Heard E, Nicodemi M, Nollmann M, Orozco M, Pombo A, Torres-Padilla ME

Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis.

Cheutin T, Cavalli G

lire la publication

Polycomb-Dependent Chromatin Looping Contributes to Gene Silencing during Drosophila Development.

Ogiyama Y, Schuettengruber B, Papadopoulos GL, Chang JM, Cavalli G

TADs are 3D structural units of higher-order chromosome organization in Drosophila.

Szabo Q, Jost D, Chang JM, Cattoni DI, Papadopoulos GL, Bonev B, Sexton T, Gurgo J, Jacquier C, Nollmann M, Bantignies F, Cavalli G

Technical Review: A Hitchhiker's Guide to Chromosome Conformation Capture.

Grob S, Cavalli G

Multi-scale 3D genome rewiring during mouse neural development.

Bonev, B., Mendelson Cohen, N., Szabo, Q., Fritsch, L., Papadopoulos, G., Lubling, Y., Xu, X., Hugnot, JP., Tanay, A., Cavalli, G.

Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

Schuettengruber, B., Bourbon, HM., Di Croce, L., Cavalli, G.

Chromosome topology guides the Drosophila Dosage Compensation Complex for target gene activation

Schauer T, Ghavi-Helm Y, Sexton T, Albig C, Regnard C, Cavalli G, Furlong EE, Becker PB.

Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila

Ciabrelli F, Comoglio F, Fellous S, Bonev B, Ninova M, Szabo Q, Xuéreb A, Klopp C, Aravin A, Paro R, Bantignies F, Cavalli G

Three-Dimensional Genome Organization and Function in Drosophila

Schwartz YB, Cavalli G.

Chromosome conformation capture technologies and their impact in understanding genome function

Sati S, Cavalli G.

Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

Cattoni DI, Gizzi AMC, Georgieva M, Di Stefano M, Valeri A, Chamousset D, Houbron C, Déjardin S, Fiche JB, González I, Chang JM, Sexton T, Marti-Renom MA, Bantignies F, Cavalli G, Nollmann M.

Organization and function of the 3D genome

Bonev B, Cavalli G.

Chromosome Conformation Capture on Chip (4C): Data Processing

Leblanc B, Comet I, Bantignies F, Cavalli G.

Following the Motion of Polycomb Bodies in Living Drosophila Embryos

Cheutin T, Cavalli G.

Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development

Loubière, V., Delest, A., Thomas, A., Bonev, B., Schuettengruber, B., Sati, S., Martinez AM., Cavalli, G.

Regulation of Genome Architecture and Function by Polycomb Proteins

Entrevan M, Schuettengruber B, Cavalli G

PRC1 proteins orchestrate three-dimensional genome architecture

Cavalli, G.

Enhancer of zeste acts as a major developmental regulator of Ciona intestinalis embryogenesis

Le Goff E, Martinand-Mari C, Martin M, Feuillard J, Boublik Y, Godefroy N, Mangeat P, Baghdiguian S, Cavalli G

Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains

Ea V, Sexton T, Gostan T, Herviou L, Baudement MO, Zhang Y, Berlivet S, Le Lay-Taha MN, Cathala G, Lesne A, Victor JM, Fan Y, Cavalli G, Forné T.

Histone H3 Serine 28 Is Essential for Efficient Polycomb-Mediated Gene Repression in Drosophila

Yung PY, Stuetzer A, Fischle W, Martinez AM, Cavalli G

The Role of Chromosome Domains in Shaping the Functional Genome

Sexton, T., Cavalli, G.

Developmental determinants in non-communicable chronic diseases and ageing

Bousquet J, Anto JM, Berkouk K, Gergen P, Pinto Antunes J, Augé P, Camuzat T, Bringer J, Mercier J, Best N, Bourret R, Akdis M, Arshad SH, Bedbrook A, Berr C, Bush A, Cavalli G, Charles MA, Clavel-Chapelon F, Gillman M, Gold DR, Goldberg M, Holloway JW, Iozzo P, Jacquemin S, Jeandel C, Kauffmann F, Keil T, Koppelman GH, Krauss-Etschmann S, Kuh D, Lehmann S, Lodrup Carlsen KC, Maier D, Méchali M, Melén E, Moatti JP, Momas I, Nérin P, Postma DS, Ritchie K, Robine JM, Samolinski B, Siroux V, Slagboom PE, Smit HA, Sunyer J, Valenta R, Van de Perre P, Verdier JM, Vrijheid M, Wickman M, Yiallouros P, Zins M.

+ Réplication et Dynamique du Génome

Chromatin driven behavior of topologically associating domains

Ciabrelli F, Cavalli G.

Cooperativity, Specificity, and Evolutionary Stability of Polycomb Targeting in Drosophila

Schuettengruber B, Oded Elkayam N, Sexton T, Entrevan M, Stern S, Thomas A, Yaffe E, Parrinello H, Tanay A, Cavalli G.

Topological organization of Drosophila hox genes using DNA fluorescent in situ hybridization

Bantignies, F., Cavalli, G.

Modeling epigenome folding: formation and dynamics of topologically associated chromatin domains

Jost D, Carrivain P, Cavalli G, Vaillant C.

Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen

Gonzalez I, Mateos-Langerak J, Thomas A, Cheutin T, Cavalli G.

A RING to Rule Them All: RING1 as Silencer and Activator

Cavalli, G.

Polycomb silencing: from linear chromatin domains to 3D chromosome folding

Cheutin T, Cavalli G

Chromosomes: now in 3D!

Cavalli, G.

Three-dimensional genome organization: a lesson from the Polycomb-Group proteins

Bantignies, F.

PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes.

Iovino N, Ciabrelli F, Cavalli G.

The 3D Genome Shapes Up For Pluripotency.

Sexton T, Cavalli G.

Functional implications of genome topology

Cavalli, G., Mistelli, T.

Polycomb domain formation depends on short and long distance regulatory cues.

Schuettengruber B, Cavalli G.

Chromosomal domains: epigenetic contexts and functional implications of genomic compartmentalization.

Tanay A, Cavalli G.

Progressive polycomb assembly on H3K27me3 compartments generates polycomb bodies with developmentally regulated motion

Cheutin T, Cavalli G.

Polycomb: a paradigm for genome organization from one to three dimensions.

Delest A, Sexton T, Cavalli G.

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome.

Sexton T, Yaffe E, Kenigsberg E, Bantignies F, Leblanc B, Hoichman M, Parrinello H, Tanay A, Cavalli G.

Molecular biology. EZH2 goes solo

Cavalli, G.

Trithorax group proteins: switching genes on and keeping them active.

Schuettengruber B, Martinez AM, Iovino N, Cavalli G.

Rolling ES Cells Down the Waddington Landscape with Oct4 and Sox2

Iovino, N., Cavalli, G.

Polycomb group proteins: repression in 3D.

Bantignies F, Cavalli G.

Editorial Review

Hetzer, M., Cavalli, G

Chromatin folding : from linear chromosomes to the 4D nucleus.

Cheutin, T., Bantignies, F., Leblanc, B., Cavalli, G.

From linear genes to Epigenetic inheritance of three dimensional Epigenomes.

Cavalli, G.

A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber.

Comet, I., Schuettengruber, B., Sexton, T., Cavalli, G

Polycomb-dependent Regulatory Contacts between Distant Hox Loci in Drosophila,

Bantignies, F., Roure, V., Comet, I., Leblanc, B., Schuttengruber, B., Bonnet, J., Tixier, V., Mas, A., Cavalli, G.

The DUBle life of polycomb complexes

Schuettengruber, B., Cavalli, G

Uncovering a tumor-suppressor function for Drosophila polycomb group genes.

Martinez, AM., Cavalli, G

Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice.

Schuettengruber B, Cavalli G.

Genomic interactions: Chromatin loops and gene meeting points in transcriptional regulation

Sexton, T., Bantignies, F., Cavalli, G.

Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling

Martinez, AM., Schuettengruber, B., Sakr, S., Janic, A., Gonzalez, C., and Cavalli, G.

Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos

Schuettengruber B, Ganapathi M, Leblanc B, Portoso M, Jaschek R, Tolhuis B, van Lohuizen M, Tanay A, Cavalli G.

Epigenetics and the control of multicellularity. Workshop on Chromatin at the Nexus of Cell Division and Differentiation.

Reuter G, Cavalli G.

Chapter 2 polycomb group proteins and long-range gene regulation.

Mateos-Langerak J, Cavalli G

The Role of RNAi and Noncoding RNAs in Polycomb Mediated Control of Gene Expression and Genomic Programming.

Portoso, M, and Cavalli, G.

Idefix insulator activity can be modulated by nearby regulatory elements.

Brasset E, Bantignies F, Court F, Cheresiz S, Conte C, Vaury C.

Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex.

Lanzuolo C, Roure V, Dekker J, Bantignies F, Orlando V.

Visualizing macromolecules with fluoronanogold: from photon microscopy to electron tomography.

Cheutin, T., Sauvage, C., Tchélidzé, P., O

Chromosome kissing

Cavalli, G.

Genome Regulation by Polycomb and Trithorax Proteins.

Schuettengruber B, Chourrout D, Vervoort M, Leblanc B, Cavalli G.

Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions.

Lanctot C, Cheutin T, Cremer M, Cavalli G, Cremer T

Polycomb controls the cell fate.

Negre N, Cavalli G.

Mapping the distribution of chromatin proteins by ChIP on chip.

Negre N, Lavrov S, Hennetin J, Bellis M, Cavalli G.

From genetics to epigenetics: the tale of Polycomb group and trithorax group genes.

Grimaud C, Negre N, Cavalli G.

PRE-Mediated Bypass of Two Su(Hw) Insulators Targets PcG Proteins to a Downstream Promoter.

Comet I, Savitskaya E, Schuettengruber B, Negre N, Lavrov S, Parshikov A, Juge F, Gracheva E, Georgiev P, Cavalli G.

Chromosomal Distribution of PcG Proteins during Drosophila Development.

Negre N, Hennetin J, Sun LV, Lavrov S, Bellis M, White KP, Cavalli G.

The role of polycomb group proteins in cell cycle regulation during development.

Martinez AM, Cavalli G.

Polycomb group-dependent Cyclin A repression in Drosophila.

Martinez AM, Colomb S, Dejardin J, Bantignies F, Cavalli G.

RNAi components are required for nuclear clustering of Polycomb group response elements.

Grimaud C, Bantignies F, Pal-Bhadra M, Ghana P, Bhadra U, Cavalli G.

Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity.

Cavalli G.

Cellular memory and dynamic regulation of polycomb group proteins.

Bantignies F, Cavalli G.

Epigenetic inheritance of chromatin states mediated by Polycomb- and trithorax group proteins in Drosophila

Déjardin, J., and Cavalli, G.

Recruitment of Drosophila Polycomb Group proteins to chromatin by DSP1

Déjardin, J., Rappailles, A., Cuvier, O., Grimaud, C., Decoville, M., Locker, D., and Cavalli, G.

+ Réplication et Dynamique du Génome

Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1

Dejardin J, Cavalli G.

The epigenome network of excellence.

Akhtar A, Cavalli G

Dissection of a natural RNA silencing process in the Drosophila melanogaster germ line

Aravin, A. A., Klenov, M. S., Vagin, V. V., Bantignies, F., Cavalli, G., and Gvozdev, V. A.

Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module

Déjardin, J., and Cavalli, G.

Interaction between GAF and Mod(mdg4) proteins promotes insulator bypass in Drosophila

Melnikova, L., Juge, F., Gruzdeva, N., Mazur, A., Cavalli, G., and Georgiev, P.

Combined immunostaining and FISH analysis of polytene chromosomes

Lavrov, S., Déjardin, J., and Cavalli, G.

SNR1 is an essential subunit in a subset of drosophila brm complexes, targeting specific functions during development

Zraly, C. B., Marenda, D. R., Nanchal, R., Cavalli, G., Muchardt, C., and Dingwal, A.K.

Protein-DNA interaction mapping using genomic tiling path microarrays in Drosophila

Sun, L. V., Chen, L., Greil, F., Nègre, N., Li, T. R., Cavalli, G., Zhao, H., Van Steensel, B., and White, K.

Inheritance of Polycomb-dependent chromosomal interactions in Drosophila

Bantignies, F., Grimaud, C., Lavrov, S., Gabut, M., and Cavalli, G.

Chromatin as a eukaryotic template of genetic information

Cavalli, G.

The MYST Domain Acetyltransferase Chameau Functions in Epigenetic Mechanisms of Transcriptional Repression

Grienenberger, A., Miotto, B., Sagnier, T., Cavalli, G., Schramke, V., Geli, V., Mariol, M. C., Berenger, H., Graba, Y., and Pradel, J.

Epigenetic Inheritance of active chromatin after removal of the main transactivator

Cavalli, G., Paro, R.

Mapping DNA target sites of chromatin-associated proteins by formaldehyde cross-linking in Drosophila embryos.

Cavalli, G., Orlando, V., and Paro, R.

The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis

11) Cavalli, G., and Paro, R.

Thèses et hdr

Étude du repliement tridimensionnel de la chromatine en domaines topologiques 27/11/2019

Soutenue par Quentin Szabo le 27/11/2019 sous la direction de Frédéric Bantignies et de Giacomo Cavalli

Rôle dynamique du PRC1 au cours du développement normal et de la tumorigenèse chez Drosophila melanogaster 16/11/2018

Soutenue par Vincent Loubière le 16/11/2018 sous la direction de Anne/Marie Martinez et de Giacomo Cavalli

Caractérisation de la diversité des sites de fixation des protéines du groupe Polycomb chez la Drosophile 29/09/2017

par Marianne Entrevan le 29/09/2017 sous la direction de Giacomo Cavalli et de Bernd Schuttengruber

Héritage transgénérationnel stable d'états chromatiniens alternatifs chez Drosophila melanogaster 16/12/2015

Defended by Filippo Ciabrelli on 16/12/2015 under the supervision of Giacomo Cavalli

Histone H3 Serine 28 is essential for efficient Polycomb/mediated gene repression in Drosophila 09/02/2015

Soutenue par Yuk Kwong Yung le 09/02/2015 sous la direction de Giacomo Cavalli

Ciblage dynamique et différentiel des complexes Polycomb au cours du développement de Drosophila melanogaster 30/11/2012

Anna Delest, 30/11/2012

Fonction différentielle des protéines du groupe Polycomb durant le développement de la Drosophile 24/11/2011

Soutenue par Samy Sakr le 24/10/2011

Etude génomique et structurale de la chromatine chez la Drosophile 24/10/2011

Benjamin Leblanc, 23/06/2011

Le noyau cellulaire et la régulation génique par les protéines du groupe Polycomb 28/10/2010

Bernd Stadelmayer 28/10/2010

Rôle des protéines du groupe Polycomb et trithorax dans l'organisation nucléaire des gènes homéotiques chez Drosophila melanogaster 10/12/2008

Virginie Roure 10/12/2008

Etudes moléculaires des interactions fonctionnelles entre la répression dépendante des protéines du groupe Polycomb et les insulateurs de gipsy chez la drosophile 20/11/2007

Itys Comet 20/11/2007

Recherche des Gènes Cibles des Protéines du Groupe Polycomb (PcG) chez la Drosophile 28/11/2005

Nicolas Nègre 28/11/2005

Séquences et facteurs nécessaires à la mémoire épigénétique des états chromatiniens 27/05/2004

Jérôme Déjardin 27/05/2004

BONEV Boyan
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Chercheur
SZABO Quentin
SZABO Quentin
Chercheur
AKILLI Nazli
AKILLI Nazli
Doctorant
DELEST Anna
DELEST Anna
Doctorant
DENAUD Sandrine
DENAUD Sandrine
Doctorant
ENTREVAN Marianne
ENTREVAN Marianne
Doctorant
NEGRE Nicolas
NEGRE Nicolas
Doctorant
PULICANI Sylvain
PULICANI Sylvain
Doctorant
REBOUL Hadrien
REBOUL Hadrien
Doctorant
SZALAY Michael
SZALAY Michael
Doctorant
YUNG Philip yuk kwong
YUNG Philip yuk kwong
Doctorant
DONJON Axelle
DONJON Axelle
ITA
FALLET Chloé
FALLET Chloé
ITA
JACQUIER-LABROCHE Caroline
JACQUIER-LABROCHE Caroline
ITA
LOUBIERE Vincent
LOUBIERE Vincent
ITA
ROUX Solène
ROUX Solène
ITA
SAKR Samy
SAKR Samy
ITA