Dufourd, Huynh et al. identify TELS1 as essential for stabilizing telomeric t-loops in mouse embryonic stem cells by controlling telomerase accessibility and telomere length. Their study establishes t-loops as fundamental protective structures independent of conventional telomere-associated proteins.

TELS1 stabilizes t-loops independently of TRF2 and controls telomere length in pluripotent cells
Dufourd, Huynh et al. Cell Reports 2025
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01031-9

Jérôme Dejardin - Biology of repetitive sequences