Skobelkina et al. show that a newly identified domain of the mitotic protein KIF2C binds to phosphorylated sites on BRCA2 to promote KIF2C condensate formation, enhancing PLK1 activity at microtubule ends, an essential step for proper chromosome alignment and genome integrity.

KIF2C condensation concentrates PLK1 and phosphorylated BRCA2 on kinetochore microtubules in mitosis
Skobelkina et al. Nucleic Acids Research 2025
https://doi.org/10.1093/nar/gkaf476

Jihane Basbous-Mesnard - Genetic instability and cancer