In this presentation, I will discuss our recent discovery of a novel function of the synaptonemal complex protein SIX6OS1, which redefines the traditional understanding of the relationship between synapsis and meiotic recombination in mammals. Classically, synapsis and crossing over (CO) are viewed as interdependent processes that ensure genetic diversity and accurate chromosome segregation during gametogenesis. However, the molecular mechanisms linking these processes remain elusive. In humans,...
Whole slide images (WSI) are microscopy images of stained tissue sections, routinely used in cancer treatment centers for diagnosis, patient stratification, and treatment selection. WSIs are large and complex, often containing hundreds of thousands of individual cells, and their analysis requires specialized algorithmic solutions.
In this lecture, I will present our recent advancements in this field. First, I will discuss our recently published approach for predicting Homologous Recombination...
Orateur:
Dr. Carolina Eliscovich (Albert Einstein College of Medicine, New-York)
Amphitheater of Genopolys
Imaging the spatial organization of single mRNA molecules in the liver
PI from Albert Einstein College of Medicine in New-York, Dr. Carolina Eliscovich works on the functional organization of the normal and regenerating liver using RNA imaging approaches, looking at both the tissue-level and the intra-cellular spatial organization of RNAs.
Orateur:
Joseph Matthew (University of Copenhagen, Department of Drug Design and pharmacology)
1st floor room at IGH
Targeting protein disorder using protein design and cyclic peptide screening
Protein disorder is abundant in biology. Many of these disordered regions are essential for cellular function, and many of these are linked to human disease. Molecules able to bind to, and modulate, disordered regions would be valuable research tools and could form the basis for future therapeutics. Yet, discovery of such molecules is highly challenging using traditional ligand- and drug- discovery methods. Here, we describe two new modalities to target disordered proteins: de novo microproteins...
All animals develop from a single-celled zygote and undergo complex morphogenetic processes to form multicellular organisms. These processes are regulated by intrinsic and extrinsic factors that drive key developmental events, such as symmetry breaking, cell division, and differentiation. Despite the remarkable conservation of these pathways across species, the evolutionary origins of these morphogenetic mechanisms remain unclear. A major challenge in addressing this question is the limited availability...
The host E3 ubiquitin ligase MARCH8 plays a crucial role in antiviral defense by targeting various viral envelope glycoproteins, preventing their incorporation into virions, and thereby reducing viral infectivity. As a key factor in the human body’s intrinsic immunity— referred to as the third immunity—MARCH8 has emerged as one of the essential players in host antiviral protection.
Our team initially worked on MARCH8 from the cell-biological aspect (1), and subsequently discovered its antiviral...
