Orateur:
Filippo Rijli (Friedrich Miescher Institute, Basel, Switzerland)
Amphitheatre Genopolys
Shaping Faces by 3D Genome Regulation
This project builds on our previous work exploring Polycomb-dependent epigenetic chromatin signatures in mouse cranial neural crest cells (Minoux et al., Science 2017). During cell migration, key transcription factor genes remain transcriptionally repressed but poised for activation. Specific cues trigger a switch from a poised to an active chromatin state in postmigratory cells, enabling position-specific transcriptional programs that drive facial structure development.
We recently mapped promoter-promoter...
In this presentation, I will discuss our recent discovery of a novel function of the synaptonemal complex protein SIX6OS1, which redefines the traditional understanding of the relationship between synapsis and meiotic recombination in mammals. Classically, synapsis and crossing over (CO) are viewed as interdependent processes that ensure genetic diversity and accurate chromosome segregation during gametogenesis. However, the molecular mechanisms linking these processes remain elusive. In humans,...