IMGT/mAb-KG: the knowledge graph for therapeutic monoclonal antibodies
Gaoussou Sanou, Taciana Manso, Konstantin Todorov, Veronique Giudicelli, Patrice Duroux and Sofia Kossida
IMGT® - le système d'information international en ImMunoGénéTique
Bases moléculaires de pathologies humaines
Les activités de recherche du Laboratoire d’ImmunoGénétique Moléculaire (LIGM), créé en Mars 1983 à Montpellier par les Professeurs Marie-Paule Lefranc and Gérard Lefranc (Université de Montpellier et CNRS) depuis 1998 à l’Institut de Génétique Humaine (IGH), portent sur l'immunogénétique moléculaire, l'immunoinformatique, la bioinformatique et les maladies génétiques rares. Nous étudions la génétique, les structures, les fonctions et les répertoires des immunoglobulines (IG) des lymphocytes B et des plasmocytes, et des récepteurs des lymphocytes T (TR) sur les lymphocytes T, qui sont des composants essentiels de l'immunité adaptative chez les humains et autres vertébrés à mâchoires (Gnathostomata).
En 1989, IMGT®, the international ImMunoGeneTics® information system®, qui est à l’origine de l'immunoinformatique, a été créé par Marie-Paule Lefranc (Université de Montpellier et CNRS). Fondé sur les concepts d’IMGT-ONTOLOGY et les règles de l’‘IMGT Scientific chart’ développés par LIGM, IMGT® est devenu la référence mondiale en immunogénétique et immunoinformatique et un pionnier dans la résolution des défis immunoinformatiques. IMGT® est une marque déposée CNRS (EU, Canada et USA). IMGT® est certifié ISO 9001: 2008 depuis 2010 et NFX 50-900 depuis 2014.
IMGT® est spécialisé dans les protéines d'IG et TR et d'histocompatibilité majeure (MH) des vertébrés et dans la superfamille des immunoglobulines (IgSF), la superfamille des protéines MH (MhSF) et les protéines apparentées du système immunitaire (RPI) des invertébrés et vertébrés. IMGT® est une ressource de connaissance intégrée de haute qualité qui fournit un accès commun aux gènes, séquences et structures spécialement annotés. IMGT® comprend sept bases de données (IMGT/LIGM-DB, une base de données standardisée de 178.929 séquences nucléotidiques d’IG et TR avec traduction de 351 espèces en mai 2017; IMGT/GENE-DB, IMGT/CLL-DB, IMGT/PRIMER-DB, IMGT/2Dstructure-DB, IMGT/3Dstructure-DB et IMGT/mAb-DB), dix-sept outils interactifs et plus de 20.000 pages de ressources Web. IMGT/DomainGapAlign est largement utilisé pour l'ingénierie des anticorps et la conception d'anticorps humanisés car il permet la définition précise des FR-IMGT et CDR-IMGT et la comparaison standardisée des séquences d'acides aminés entre les domaines V non humains (souris, rat ...) et les gènes humains ‘germline’ les plus proches. IMGT/HighV-QUEST, le premier et à ce jour le seul portail en ligne pour les données IG et TR de séquençage de nouvelle génération (Next Generation Sequencing, NGS), a analysé à ce jour (avril 2017) plus de 12,5 milliards de séquences IG et TR, de 2043 utilisateurs (45% USA, 35% Europe, 20 % autres pays).
Depuis juillet 1995, IMGT® est disponible sur le Web. IMGT® est utilisé par des chercheurs et scientifiques, universitaires et d’entreprises pharmaceutiques et biotechnologiques, impliqués dans la recherche fondamentale, la recherche médicale (maladies auto-immunes et infectieuses, SIDA, leucémie, lymphome, myélome), la recherche vétérinaire, la génomique (la diversité du génome et l'évolution du système immunitaire adaptatif), la biotechnologie liée à l'ingénierie des anticorps pour l'humanisation d'anticorps thérapeutiques, le diagnostic (détection de maladies résiduelles minimales) et les approches thérapeutiques (greffes, immunothérapie, vaccination). Le serveur Web IMGT® à Montpellier est accessible par plus de 80 000 sites par an. IMGT® a une réponse exceptionnelle avec plus de 150.000 demandes par mois.
Les anticorps représentent un grand nombre de substances pharmaceutiques soumises au programme de la Dénomination Commune Internationale (DCI) de l’Organisation Mondiale de la Santé (OMS) (WHO INN). La définition INN des anticorps repose sur les concepts d’IMGT-ONTOLOGY. Depuis 2008, les séquences d'acides aminés des anticorps monoclonaux (mAb, INN suffix -mab), des protéines de fusion pour les applications immunitaires (FPIA) et des protéines composites pour les applications cliniques (CPCA) ayant un INN sont entrées dans IMGT®. Ces applications thérapeutiques mettent l'accent sur l'importance des concepts d’IMGT-ONTOLOGY pour faire le lien entre séquences et structures 2D et 3D des anticorps.
Un autre intérêt de recherche, en collaboration principalement avec l'Unité de Génétique Médicale, de l'Université St-Joseph, Beyrouth, et avec d'autres équipes en Tunisie et en Algérie et l'Hôpital pour Enfants de Boston (Pr Raif GEHA) concerne des déficiences immunitaires et des maladies génétiques autosomiques récessives rares dans les familles consanguines (il y a jusqu'à 25% de mariages entre cousins, souvent cousins germains et même double cousins germains). Les patients sont autozygotes (homozygotes par descendance) pour des gènes et des haplotypes mutés très rares, présents dans l'(les) ancêtre(s) commun(s) de leurs parents. Ces génotypes exceptionnels sont des points de départ inestimables pour permettre l'identification plus rapidement des gènes mutés encore inconnus. Leurs fonctions dans l'organisation cellulaire ou dans les voies de signalisation, y compris l’épigénétique et l’inhibition de l’expression par les microARN, sont démasquées et peuvent être étudiées. Le conseil génétique peut être effectué dans ces familles.
La meilleure compréhension de la base moléculaire de la pathophysiologie permet de faire les meilleurs choix dans le développement d'outils de diagnostic et de thérapies innovantes. Cette recherche est bénéfique non seulement dans le cas des maladies monogéniques, mais aussi celui des maladies complexes. En effet, la consanguinité, responsable aussi de l'homozygotie de grandes régions chromosomiques, identiques par descendance, permet de découvrir plus facilement les réseaux génétiques. Cette approche est également valable pour la recherche de susceptibilité ou de protection génétique contre les maladies infectieuses.
Publications de l'équipe
Mechanisms of action of monoclonal antibodies in oncology integrated in IMGT/mAb-DB.
Manso T, Kushwaha A, Abdollahi N, Duroux P, Giudicelli V, Kossida S
IMGT-KG: A Knowledge Graph for Immunogenetics.
Sanou G, Giudicelli V, Abdollahi N, Kossida S, Todorov K, Duroux P
Deep Learning Concepts For Genomics : An Overview.
Elazami Elhassani M, Maisonnasse L, Olgiati A, Rey J, Rehali M, Duroux P, Giudicelli V, Kossida S
IMGT® Immunoinformatics Tools for Standardized V-DOMAIN Analysis.
Giudicelli V, Duroux P, Rollin M, Aouinti S, Folch G, Jabado-Michaloud J, Lefranc MP, Kossida S
Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: the 2022 update of the recommendations by ERIC, the European Research Initiative on CLL.
Agathangelidis A, Chatzidimitriou A, Chatzikonstantinou T, Tresoldi C, Davis Z, Giudicelli V, Kossida S, Belessi C, Rosenquist R, Ghia P, Langerak AW, Davi F, Stamatopoulos K, ERIC: the European Research Initiative on CLL
IMGT® Biocuration and Analysis of the Rhesus Monkey IG Loci.
Nguefack Ngoune V, Bertignac M, Georga M, Papadaki A, Albani A, Folch G, Jabado-Michaloud J, Giudicelli V, Duroux P, Lefranc MP, Kossida S
IMGT® databases, related tools and web resources through three main axes of research and development.
Manso T, Folch G, Giudicelli V, Jabado-Michaloud J, Kushwaha A, Nguefack Ngoune V, Georga M, Papadaki A, Debbagh C, Pégorier P, Bertignac M, Hadi-Saljoqi S, Chentli I, Cherouali K, Aouinti S, El Hamwi A, Albani A, Elazami Elhassani M, Viart B, Goret A, Tran A, Sanou G, Rollin M, Duroux P, Kossida S
IMGT® Biocuration and Comparative Analysis of Bos taurus and Ovis aries TRA/TRD Loci.
Pégorier P, Bertignac M, Nguefack Ngoune V, Folch G, Jabado-Michaloud J, Giudicelli V, Duroux P, Lefranc MP, Kossida S
Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL.
Agathangelidis A, Chatzidimitriou A, Gemenetzi K, Giudicelli V, Karypidou M, Plevova K, Davis Z, Yan XJ, Jeromin S, Schneider C, Pedersen LB, Tschumper RC, Sutton LA, Baliakas P, Scarfò L, van Gastel EJ, Armand M, Tausch E, Biderman B, Baer C, Bagnara D, Navarro A, Langlois de Septenville A, Guido V, Mitterbauer-Hohendanner G, Dimovski A, Brieghel C, Lawless S, Meggendorfer M, Brazdilova K, Ritgen M, Facco M, Tresoldi C, Visentin A, Patriarca A, Catherwood M, Bonello L, Sudarikov A, Vanura K, Roumelioti M, Skuhrova Francova H, Moysiadis T, Veronese S, Giannopoulos K, Mansouri L, Karan-Djurasevic T, Sandaltzopoulos R, Bödör C, Fais F, Kater AP, Panovska I, Rossi D, Alshemmari S, Panagiotidis P, Costeas P, Espinet B, Antic D, Foroni L, Montillo M, Trentin L, Stavroyianni N, Gaidano G, Francia di Celle P, Niemann C, Campo E, Anagnostopoulos A, Pott C, Fischer K, Hallek M, Oscier D, Stilgenbauer S, Haferlach C, Jelinek D, Chiorazzi N, Pospisilova S, Lefranc MP, Kossida S, Langerak AW, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K
Immunoglobulins or Antibodies: IMGT® Bridging Genes, Structures and Functions.
Lefranc MP, Lefranc G
IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB.
Pégorier P, Bertignac M, Chentli I, Nguefack Ngoune V, Folch G, Jabado-Michaloud J, Hadi-Saljoqi S, Giudicelli V, Duroux P, Lefranc MP, Kossida S
Topology and expressed repertoire of the Felis catus T cell receptor loci.
Radtanakatikanon A, Keller SM, Darzentas N, Moore PF, Folch G, Nguefack Ngoune V, Lefranc MP, Vernau W
IMGT® and 30 Years of Immunoinformatics Insight in Antibody V and C Domain Structure and Function.
Lefranc MP, Lefranc G
Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming.
Ohlin M, Scheepers C, Corcoran M, Lees WD, Busse CE, Bagnara D, Thörnqvist L, Bürckert JP, Jackson KJL, Ralph D, Schramm CA, Marthandan N, Breden F, Scott J, Matsen Iv FA, Greiff V, Yaari G, Kleinstein SH, Christley S, Sherkow JS, Kossida S, Lefranc MP, van Zelm MC, Watson CT, Collins AM
Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations.
Xochelli A, Bikos V, Polychronidou E, Galigalidou C, Agathangelidis A, Charlotte F, Moschonas P, Davis Z, Colombo M, Roumelioti M, Sutton LA, Groenen P, van den Brand M, Boudjoghra M, Algara P, Traverse-Glehen A, Ferrer A, Stalika E, Karypidou M, Kanellis G, Kalpadakis C, Mollejo M, Pangalis G, Vlamos P, Amini RM, Pospisilova S, Gonzalez D, Ponzoni M, Anagnostopoulos A, Giudicelli V, Lefranc MP, Espinet B, Panagiotidis P, Piris MA, Du MQ, Rosenquist R, Papadaki T, Belessi C, Ferrarini M, Oscier D, Tzovaras D, Ghia P, Davi F, Hadzidimitriou A, Stamatopoulos K
Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling.
Kumbhar R, Vidal-Eychenié S, Kontopoulos DG, Larroque M, Larroque C, Basbous J, Kossida S, Ribeyre C, Constantinou A
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Instabilité Génétique et Cancer
Thymoquinone Potently Enhances the Activities of Classically Activated Macrophages Pulsed with Necrotic Jurkat Cell Lysates and the Production of Antitumor Th1-/M1-Related Cytokines.
Miliani M, Nouar M, Paris O, Lefranc G, Mennechet F, Aribi M
Use of IMGT® Databases and Tools for Antibody Engineering and Humanization.
Lefranc MP, Ehrenmann F, Kossida S, Giudicelli V, Duroux P
Coupling of Single Molecule, Long Read Sequencing with IMGT/HighV-QUEST Analysis Expedites Identification of SIV gp140-Specific Antibodies from scFv Phage Display Libraries.
Han SY, Antoine A, Howard D, Chang B, Chang WS, Slein M, Deikus G, Kossida S, Duroux P, Lefranc MP, Sebra RP, Smith ML, Fofana IBF
No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy.
Baliakas P, Mattsson M, Hadzidimitriou A, Minga E, Agathangelidis A, Sutton LA, Scarfo L, Davis Z, Yan XJ, Plevova K, Sandberg Y, Vojdeman FJ, Tzenou T, Chu CC, Veronese S, Mansouri L, Smedby KE, Giudicelli V, Nguyen-Khac F, Panagiotidis P, Juliusson G, Anagnostopoulos A, Lefranc MP, Trentin L, Catherwood M, Montillo M, Niemann CU, Langerak AW, Pospisilova S, Stavroyianni N, Chiorazzi N, Oscier D, Jelinek DF, Shanafelt T, Darzentas N, Belessi C, Davi F, Ghia P, Rosenquist R, Stamatopoulos K
When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions.
Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M, Burrone O, Maynard J, Ferrara F, Trimmer JS, Görnemann J, Glanville J, Wolf P, Frenzel A, Wong J, Koh XY, Eng HY, Lane D, Lefranc MP, Clark M, Dübel S
Pacific Biosciences Sequencing and IMGT/HighV-QUEST Analysis of Full-Length Single Chain Fragment Variable from an In Vivo Selected Phage-Display Combinatorial Library.
Hemadou A, Giudicelli V, Smith ML, Lefranc MP, Duroux P, Kossida S, Heiner C, Hepler NL, Kuijpers J, Groppi A, Korlach J, Mondon P, Ottones F, Jacobin-Valat MJ, Laroche-Traineau J, Clofent-Sanchez G
Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci.
Martin J, Ponstingl H, Lefranc MP, Archer J, Sargan D, Bradley A
Epidermodysplasia verruciformis as a manifestation of ARTEMIS deficiency in a young adult.
Tahiat A, Badran YR, Chou J, Cangemi B, Lefranc G, Labgaa ZM, Oussalam S, Kaddouri-Slimani A, Belarbi A, Bendissari-Bouzid K, Gharnaout M, Geha RS, Djidjik R, Massaad MJ
IG and TR single chain fragment variable (scFv) sequence analysis: a new advanced functionality of IMGT/V-QUEST and IMGT/HighV-QUEST
Giudicelli V, Duroux P, Kossida S, Lefranc MP.
Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies
Deiss TC, Vadnais M, Wang F, Chen PL, Torkamani A, Mwangi W, Lefranc MP, Criscitiello MF, Smider VV.
TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin.
Khalifa O, Balandraud N, Lambert N, Auger I, Roudier J, Sénéchal A, Geneviève D, Picard C, Lefranc G, Touitou I, Mrenda BM, Benedito C, Pardoux E, Gagez AL, Pers YM, Jorgensen C, Mahjoub T, Apparailly F.
Facial cutaneo-mucosal venous malformations can develop independently of mutation of TEK gene but may be associated with excessive expression of Src and p-Src
Brahami N, Subramaniam S, Al-Ddafari MS, Elkaim C, Harmand PO, Sari BE, Lefranc G, Aribi M.
Detection of Sp110 by Flow Cytometry and Application to Screening Patients for Veno-occlusive Disease with Immunodeficiency.
Marquardsen FA, Baldin F, Wunderer F, Al-Herz W, Mikhael R, Lefranc G, Baz Z, Rezaee F, Hanna R, Kfir-Erenfeld S, Stepensky P, Meyer B, Jauch A, Bigler MB, Burgener AV, Higgins R, Navarini AA, Church JA, Chou J, Geha R, Notarangelo LD, Hess C, Berger CT, Bloch DB, Recher M.
DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells.
Massaad MJ, Cangemi B, Al-Herz W, LeFranc G, Freeman A, Baxi S, Keles S, Metin A, Dasouki M, Sobh A, Kanariou M, Al-Sukaiti N, Ozen A, Ochs H, Chatila TA, Manis JP, Geha R.
Web Sites of Interest to Immunologists.
Lefranc M.P.
Novel Structural Parameters of Ig-Ag Complexes Yield a Quantitative Description of Interaction Specificity and Binding Affinity.
Marillet S, Lefranc MP, Boudinot P, Cazals F.
Human Immunoglobulin Heavy Gamma Chain Polymorphisms: Molecular Confirmation Of Proteomic Assessment.
Dambrun M, Dechavanne C, Emmanuel A, Aussenac F, Leduc M, Giangrande C, Vinh J, Dugoujon JM, Lefranc MP, Guillonneau F, Migot-Nabias F.
High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges
Langerak AW, Brüggemann M, Davi F, Darzentas N, van Dongen JJM, Gonzalez D, Cazzaniga G, Giudicelli V, Lefranc MP, Giraud M, Macintyre EA, Hummel M, Pott C, Groenen PJTA, Stamatopoulos K; EuroClonality-NGS Consortium
Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations
Rosenquist R, Ghia P, Hadzidimitriou A, Sutton LA, Agathangelidis A, Baliakas P, Darzentas N, Giudicelli V, Lefranc MP, Langerak AW, Belessi C, Davi F, Stamatopoulos K.
Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes.
Xochelli A, Baliakas P, Kavakiotis I, Agathangelidis A, Sutton LA, Minga E, Ntoufa S, Tausch E, Yan XJ, Shanafelt T, Plevova K, Boudjogra M, Rossi D, Davis Z, Navarro A, Sandberg Y, Vojdeman FJ, Scarfo L, Stavroyianni N, Sudarikov A, Veronese S, Tzenou T, Karan-Djurasevic T, Catherwood M, Kienle D, Chatzouli M, Facco M, Bahlo J, Pott C, Pedersen LB, Mansouri L, Smedby KE, Chu CC, Giudicelli V, Lefranc MP, Panagiotidis P, Juliusson G, Anagnostopoulos A, Vlahavas I, Antic D, Trentin L, Montillo M, Niemann C, Döhner H, Langerak AW, Pospisilova S, Hallek M, Campo E, Chiorazzi N, Maglaveras N, Oscier D, Gaidano G, Jelinek DF, Stilgenbauer S, Chouvarda I, Darzentas N, Belessi C, Davi F, Hadzidimitriou A, Rosenquist R, Ghia P, Stamatopoulos K.
Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.
Prieur A, Cappellini M, Habif G, Lefranc MP, Mazard T, Morency E, Pascussi JM, Flacelière M, Cahuzac N, Vire B, Dubuc B, Durochat A, Liaud P, Ollier J, Pfeiffer C, Poupeau S, Saywell V, Planque C, Assenat E, Bibeau F, Bourgaux JF, Pujol P, Sézeur A, Ychou M, Joubert D.
Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data
Rubelt F, Busse CE, Bukhari SAC, Bürckert JP, Mariotti-Ferrandiz E, Cowell LG, Watson CT, Marthandan N, Faison WJ, Hershberg U, Laserson U, Corrie BD, Davis MM, Peters B, Lefranc MP, Scott JK, Breden F; AIRR Community, Luning Prak ET, Kleinstein SH
Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data.
Breden F, Luning Prak ET, Peters B, Rubelt F, Schramm CA, Busse CE, Vander Heiden JA, Christley S, Bukhari SAC, Thorogood A, Matsen Iv FA, Wine Y, Laserson U, Klatzmann D, Douek DC, Lefranc MP, Collins AM, Bubela T, Kleinstein SH, Watson CT, Cowell LG, Scott JK, Kepler TB.
IMGT/StatClonotype for Pairwise Evaluation and Visualization of NGS IG and TR IMGT Clonotype (AA) Diversity or Expression from IMGT/HighV-QUEST
Aouinti S, Giudicelli V, Duroux P, Malouche D, Kossida S, Lefranc MP
Structuprint: a scalable and extensible tool for two-dimensional representation of protein surfaces
Kontopoulos DG, Vlachakis D, Tsiliki G, Kossida S.
Correction: IMGT/HighV-QUEST Statistical Significance of IMGT Clonotype (AA) Diversity per Gene for Standardized Comparisons of Next Generation Sequencing Immunoprofiles of Immunoglobulins and T Cell Receptors
Aouinti S, Malouche D, Giudicelli V, Kossida S, Lefranc MP.
COPD characteristics in subjects carrying the rare alpha-1 antitrypsin variant PIMMmalton
Denden S, Bouden B, Boudawara Keskes N, Knani J, Hassine M, Lefranc G, Ben Chibani J, Haj Khelil A
Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals.
Boudinot P, Mondot S, Jouneau L, Teyton L, Lefranc MP, Lantz O.
Cynomolgus macaque (Macaca fascicularis) immunoglobulin heavy chain locus description.
Yu GY, Mate S, Garcia K, Ward MD, Brueggemann E, Hall M, Kenny T, Sanchez-Lockhart M, Lefranc MP, Palacios G.
Erratum to: Genomic and expression analyses of Tursiops truncatus T cell receptor gamma (TRG) and alpha/delta (TRA/TRD) loci reveal a similar basic public γδ repertoire in dolphin and human.
Linguiti G, Antonacci R, Tasco G, Grande F, Casadio R, Massari S, Castelli V, Consiglio A, Lefranc MP, Ciccarese S.
12. Combined IKZF1 and IG markers as new tools for diagnosis and minimal residual disease assessment in Tunisian B-ALL
Besbes S, Hamadou WS, Boulland ML, Lefranc MP, Ben Youssef Y, Achour B, Khelif A, Fest T, Soua Z.
IMGT/HighV-QUEST statistical significance of IMGT clonotype (AA) diversity per gene for standardized comparisons of next generation sequencing immunoprofiles of immunoglobulins and T cell receptors
Aouinti, S., Malouche D, Giudicelli V, Kossida, S., Lefranc, M-P
Sheep (Ovis aries) T cell receptor alpha (TRA) and delta (TRD) genes and genomic organization of the TRA/TRD locus.
Piccinni B, Massari S, Caputi Jambrenghi A, Giannico F, Lefranc MP, Ciccarese S, Antonacci R
Antibody Informatics: IMGT, the International ImMunoGeneTics Information System
Lefranc MP.
From IMGT-ONTOLOGY to IMGT/HighV-QUEST for NGS immunoglobulin (IG) and T cell receptor (TR) repertoires in autoimmune and infectious diseases
Giudicelli V., Duroux P., Lavoie A, Aouinti S, Lefranc M-P, Kossida S
DrugOn: a fully integrated pharmacophore modeling and structure optimization toolkit
Vlachakis D, Fakourelis P, Megalooikonomou V, Makris C, Kossida S
A Novel Mutation of the hGR Gene Causing Chrousos Syndrome
Nicolaides NC, Geer EB, Vlachakis D, Roberts ML, Psarra AM, Moutsatsou P, Sertedaki A, Kossida S, Charmandari E
A broad range of mutations in HIV-1 neutralizing human monoclonal antibodies specific for V2, V3, and the CD4 binding site
Li L, Wang XH, Williams C, Volsky B, Steczko O, Seaman MS, Luthra K, Nyambi P, Nadas A, Giudicelli V, Lefranc MP, Zolla-Pazner S, Gorny MK
Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
Baliakas P, Agathangelidis A, Hadzidimitriou A, Sutton LA, Minga E, Tsanousa A, Scarfò L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M, Tzenou T, Chatzouli M, Chu CC, Veronese S, Gardiner A, Mansouri L, Smedby KE, Pedersen LB, Moreno D, Van Lom K, Giudicelli V, Francova HS, Nguyen-Khac F, Panagiotidis P, Juliusson G, Angelis L, Anagnostopoulos A, Lefranc MP, Facco M, Trentin L, Catherwood M, Montillo M, Geisler CH, Langerak AW, Pospisilova S, Chiorazzi N, Oscier D, Jelinek DF, Darzentas N, Belessi C, Davi F, Ghia P, Rosenquist R, Stamatopoulos K
Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia
Xochelli A, Agathangelidis A, Kavakiotis I, Minga E, Sutton LA, Baliakas P, Chouvarda I, Giudicelli V, Vlahavas I, Maglaveras N, Bonello L, Trentin L, Tedeschi A, Panagiotidis P, Geisler C, Langerak AW, Pospisilova S, Jelinek DF, Oscier D, Chiorazzi N, Darzentas N, Davi F, Ghia P, Rosenquist R, Hadzidimitriou A, Belessi C, Lefranc MP, Stamatopoulos K
IMGT®, the international ImMunoGeneTics information system® 25 years on
Lefranc MP, Giudicelli V, Duroux P, Jabado-Michaloud J, Folch G, Aouinti S, Carillon E, Duvergey H, Houles A, Paysan-Lafosse T, Hadi-Saljoqi S, Sasorith S, Lefranc G, Kossida S.
The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency.
Engelhardt KR, Gertz ME, Keles S, Schäffer AA, Sigmund EC, Glocker C, Saghafi S, Pourpak Z, Ceja R, Sassi A, Graham LE, Massaad MJ, Mellouli F, Ben-Mustapha I, Khemiri M, Kilic SS, Etzioni A, Freeman AF, Thiel J, Schulze I, Al-Herz W, Metin A, Sanal Ö, Tezcan I, Yeganeh M, Niehues T, Dueckers G, Weinspach S, Patiroglu T, Unal E, Dasouki M, Yilmaz M, Genel F, Aytekin C, Kutukculer N, Somer A, Kilic M, Reisli I, Camcioglu Y, Gennery AR, Cant AJ, Jones A, Gaspar BH, Arkwright PD, Pietrogrande MC, Baz Z, Al-Tamemi S, Lougaris V, Lefranc G, Megarbane A, Boutros J, Galal N, Bejaoui M, Barbouche MR, Geha RS, Chatila TA, Grimbacher B.
The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape
Busby GBJ, Hellenthal G, Montinaro F, Tofanelli S, Bulayeva K, Rudan I, Zemunik T, Hayward C, Toncheva D, Karachanak-Yankova S, Nesheva D, Anagnostou P, Cali F, Brisighelli F, Romano V, Lefranc G, Buresi C, Ben Chibani J, Haj-Khelil A, Denden S, Ploski R, Krajewski P, Hervig T, Moen T, Herrera RJ, Wilson JF, Myers S, Capelli C.
How to use IMGT® for therapeutic antibody engineering
Lefranc MP.
IMGT® immunoglobulin repertoire analysis and antibody humanization.
Lefranc MP.
Antibody informatics: IMGT®, the international ImMunoGeneTics information system®
Lefranc MP
Lack of TEK Gene Mutation in Patients with Cutaneomucosal Venous Malformations from the North-Western Region of Algeria.
Brahami N, Aribi M, Sari BE, Khau Van Kien P, Touitou I, Lefranc G, Barat-Houari M
Immunoglobulins: 25 years of immunoinformatics and IMGT-ONTOLOGY
Lefranc, MP.
Antibody informatics for drug discovery
Shirai H, Prades C, Vita R, Marcatili P, Popovic B, Xu J, Overington JP, Hirayama K, Soga S, Tsunoyama K, Clark D, Lefranc MP, Ikeda K.
2. Immunoinformatics of the V, C, and G Domains: IMGT(®) Definitive System for IG, TR and IgSF, MH, and MhSF.
Lefranc, MP.
DBAASP: Database of Antimicrobial Activity and Structure of Peptides
Gogoladze G, Grigolava M, Vishnepolsky B, Chubinidze M, Duroux P, Lefranc MP, Pirtskhalava M.
Characteristics of the somatic hypermutation in the Camelus dromedarius T cell receptor gamma (TRG) and delta (TRD) variable domains.
Ciccarese S, Vaccarelli G, Lefranc MP, Tasco G, Consiglio A, Casadio R, Linguiti G, Antonacci R.
Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics
Lefranc MP.
Antibody V and C Domain Sequence, Structure, and Interaction Analysis with Special Reference to IMGT(®).
Alamyar E, Giudicelli V, Duroux P, Lefranc MP.
Characterization of a new V gene replacement in the absence of activation-induced cytidine deaminase and its contribution to human B-cell receptor diversity
Ouled-Haddou H, Ghamlouch H, Regnier A, Trudel S, Herent D, Lefranc MP, Marolleau JP, Gubler B.
Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis.
Janssen E, Tsitsikov E, Al-Herz W, Lefranc G, Megarbane A, Dasouki M, Bonilla FA, Chatila T, Schneider L, Geha RS.
Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-α 2b therapy.
Keles S, Jabara HH, Reisli I, McDonald DR, Barlan I, Hanna-Wakim R, Dbaibo G, Lefranc G, Al-Herz W, Geha RS, Chatila TA
Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells.
Janssen E, Morbach H, Ullas S, Bannock JM, Massad C, Menard L, Barlan I, Lefranc G, Su H, Dasouki M, Al-Herz W, Keles S, Chatila T, Geha RS, Meffre E.
IMGT® information system
Lefranc MP.
IMGT-ONTOLOGY
Giudicelli V and Lefranc M.-P
Deep dermatophytosis and inherited CARD9 deficiency.
Lanternier F, Pathan S, Vincent QB, Liu L, Cypowyj S, Prando C, Migaud M, Taibi L, Ammar-Khodja A, Stambouli OB, Guellil B, Jacobs F, Goffard JC, Schepers K, del Marmol V, Boussofara L, Denguezli M, Larif M, Bachelez H, Michel L, Lefranc G, Hay R, Jouvion G, Chretien F, Fraitag S, Bougnoux ME, Boudia M, Abel L, Lortholary O, Casanova JL, Picard C, Grimbacher B, Puel A.
IMGT unique numbering
Lefranc MP.
Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria.
Khaib Dit Naib O, Aribi M, Idder A, Chiali A, Sairi H, Touitou I, Lefranc G, Barat-Houari M
Deep dermatophytosis and inherited CARD9 deficiency.
Lanternier F, Pathan S, Vincent QB, Liu L, Cypowyj S, Prando C, Migaud M, Taibi L, Ammar-Khodja A, Stambouli OB, Guellil B, Jacobs F, Goffard JC, Schepers K, Del Marmol V, Boussofara L, Denguezli M, Larif M, Bachelez H, Michel L, Lefranc G, Hay R, Jouvion G, Chretien F, Fraitag S, Bougnoux ME, Boudia M, Abel L, Lortholary O, Casanova JL, Picard C, Grimbacher B, Puel A
IMGT Collier de Perles
Lefranc MP
A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.
Jabara HH, Ohsumi T, Chou J, Massaad MJ, Benson H, Megarbane A, Chouery E, Mikhael R, Gorka O, Gewies A, Portales P, Nakayama T, Hosokawa H, Revy P, Herrod H, Le Deist F, Lefranc G, Ruland J, Geha RS
Consanguinity
Lefranc M.-P and Lefranc G.
The intellectual disability of trisomy 21: differences in gene expression in a case series of patients with lower and higher IQ.
Mégarbané A, Noguier F, Stora S, Manchon L, Mircher C, Bruno R, Dorison N, Pierrat F, Rethoré MO, Trentin B, Ravel A, Morent M, Lefranc G, Piquemal D
Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia.
Mégarbané A, Pangrazio A, Villa A, Chouery E, Maarawi J, Sabbagh S, Lefranc G, Sobacchi C
The Past, Present, and Future of Immune Repertoire Biology - The Rise of Next-Generation Repertoire Analysis
Six A, Mariotti-Ferrandiz ME, Chaara W, Magadan S, Pham HP, Lefranc MP, Mora T, Thomas-Vaslin V, Walczak AM, Boudinot P
IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling.
Li S, Lefranc MP, Miles JJ, Alamyar E, Giudicelli V, Duroux P, Freeman JD, Corbin VD, Scheerlinck JP, Frohman MA, Cameron PU, Plebanski M, Loveland B, Burrows SR, Papenfuss AT, Gowans EJ.
Teleost Fish Mount Complex Clonal IgM and IgT Responses in Spleen upon Systemic Viral Infection
Castro R, Jouneau L, Pham HP, Bouchez O, Giudicelli V, Lefranc MP, Quillet E, Benmansour A, Cazals F, Six A, Fillatreau S, Sunyer O, Boudinot P.
A novel homozygous mutation in recombination activating gene 2 in 2 relatives with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome.
Chou J, Hanna-Wakim R, Tirosh I, Kane J, Fraulino D, Lee YN, Ghanem S, Mahfouz I, Mégarbané A, Lefranc G, Inati A, Dbaibo G, Giliani S, Notarangelo LD, Geha RS, Massaad MJ
Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome.
Cliffe ST, Bloch DB, Suryani S, Kamsteeg EJ, Avery DT, Palendira U, Church JA, Wainstein BK, Trizzino A, Lefranc G, Akatcherian C, Megarbané A, Gilissen C, Moshous D, Reichenbach J, Misbah S, Salzer U, Abinun M, Ong PY, Stepensky P, Ruga E, Ziegler JB, Wong M, Tangye SG, Lindeman R, Buckley MF, Roscioli T
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, Rauter I, Benson H, Schneider L, Baxi S, Recher M, Notarangelo LD, Wakim R, Dbaibo G, Dasouki M, Al-Herz W, Barlan I, Baris S, Kutukculer N, Ochs HD, Plebani A, Kanariou M, Lefranc G, Reisli I, Fitzgerald KA, Golenbock D, Manis J, Keles S, Ceja R, Chatila TA, Geha RS
DNA replication is altered in Immunodeficiency Centromeric instability Facial anomalies (ICF) cells carrying DNMT3B mutations.
Lana E, Mégarbané A, Tourrière H, Sarda P, Lefranc G, Claustres M, De Sario A
A novel deletion in ZBTB24 in a Lebanese family with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2.
Chouery E, Abou-Ghoch J, Corbani S, El Ali N, Korban R, Salem N, Castro C, Klayme S, Azoury-Abou Rjeily M, Khoury-Matar R, Debo G, Germanos-Haddad M, Delague V, Lefranc G, Mégarbané A
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
Agathangelidis A, Darzentas N, Hadzidimitriou A, Brochet X, Murray F, Yan XJ, Davis Z, van Gastel-Mol EJ, Tresoldi C, Chu CC, Cahill N, Giudicelli V, Tichy B, Pedersen LB, Foroni L, Bonello L, Janus A, Smedby K, Anagnostopoulos A, Merle-Beral H, Laoutaris N, Juliusson G, di Celle PF, Pospisilova S, Jurlander J, Geisler C, Tsaftaris A, Lefranc MP, Langerak AW, Oscier DG, Chiorazzi N, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K.
IMGT/HighV-QUEST: the IMGT® web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing
Alamyar E, Giudicelli V, Li S, Duroux P, Lefranc MP
IMGT-ONTOLOGY 2012
Giudicelli V, Lefranc MP.
IMGT(®) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS
Alamyar E, Duroux P, Lefranc MP, Giudicelli V
IMGT/DomainGapAlign: the IMGT® tool for the analysis of IG, TR, MH, IgSF, and MhSF domain amino acid polymorphism
Ehrenmann F, Lefranc MP
Human Gm, Km, and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism
Lefranc MP, Lefranc G
Organization, complexity and allelic diversity of the porcine (Sus scrofa domestica) immunoglobulin lambda locus
Schwartz, JC., Lefranc, MP., Murtaugh, MP
Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion
Schwartz, JC., Lefranc, MP., Murtaugh, MP
Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity
Kostareli, E., Gounari, M., Janus, A., Murray, F., Brochet, X., Giudicelli, V., Pospisilova, S., Oscier, D., Foroni, L., di Celle, PF., Tichy, B., Pedersen, LB., Jurlander, J., Ponzoni, M., Kouvatsi, A., Anagnostopoulos, A., Thompson, K., Darzentas, N., Lefranc, MP., Belessi, C., Rosenquist, R., Davi, F., Ghia, P., Stamatopoulos, K
Cytomegalovirus-specific CD8+ T cells targeting different peptide/HLA combinations demonstrate varying T-cell receptor diversity
Giest, S., McWhinnie, A., Lefranc, MP., Little, AM., Grace, S., Mackinnon, S., Madrigal, JA., Travers, PJ
Diversity, Molecular Characterization and Expression of T Cell Receptor γ in a Teleost Fish, the Sea Bass (Dicentrarchus labrax, L)
Buonocore F, Castro R, Randelli E, Lefranc MP, Six A, Kuhl H, Reinhardt R, Facchiano A, Boudinot P, Scapigliati G.
Mass Spectrometry Detection of G3m and IGHG3 Alleles and Follow-Up of Differential Mother and Neonate IgG3.
Dechavanne C, Guillonneau F, Chiappetta G, Sago L, Lévy P, Salnot V, Guitard E, Ehrenmann F, Broussard C, Chafey P, Le Port A, Vinh J, Mayeux P, Dugoujon JM, Lefranc MP, Migot-Nabias F.
Use of IMGT(®) databases and tools for antibody engineering and humanization
Lefranc, MP., Ehrenmann, F., Ginestoux, C., Giudicelli, V., Duroux, P
Combined analysis of EPHX1, GSTP1, GSTM1 and GSTT1 gene polymorphisms in relation to chronic obstructive pulmonary disease risk and lung function impairment.
Lakhdar R, Denden S, Knani J, Leban N, Daimi H, Hassine M, Lefranc G, Chibani JB, Khelil AH
Update in chronic obstructive pulmonary disease: role of antioxidant and metabolizing gene polymorphisms.
Lakhdar R, Denden S, Kassab A, Leban N, Knani J, Lefranc G, Miled A, Chibani JB, Khelil AH
Heterochromatic genes undergo epigenetic changes and escape silencing in immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome.
Brun ME, Lana E, Rivals I, Lefranc G, Sarda P, Claustres M, Mégarbané A, De Sario A
Correlation of EPHX1, GSTP1, GSTM1, and GSTT1 genetic polymorphisms with antioxidative stress markers in chronic obstructive pulmonary disease.
Lakhdar R, Denden S, Mouhamed MH, Chalgoum A, Leban N, Knani J, Lefranc G, Miled A, Ben Chibani J, Khelil AH
T cell diversity and TcR repertoires in teleost fish.
Castro R, Bernard D, Lefranc MP, Six A, Benmansour A, Boudinot P
IMGT, the International ImMunoGeneTics Information System.
Lefranc, MP
IMGT Collier de Perles for the Variable (V), Constant (C), and Groove (G) Domains of IG, TR, MH, IgSF, and MhSF
Lefranc, MP
IMGT Unique Numbering for the Variable (V), Constant (C), and Groove (G) Domains of IG, TR, MH, IgSF, and MhSF
Lefranc, MP
From IMGT-ONTOLOGY CLASSIFICATION Axiom to IMGT Standardized Gene and Allele Nomenclature: For Immunoglobulins (IG) and T Cell Receptors (TR).
Lefranc, MP
From IMGT-ONTOLOGY DESCRIPTION Axiom to IMGT Standardized Labels: For Immunoglobulin (IG) and T Cell Receptor (TR) Sequences and Structures.
Lefranc, MP
From IMGT-ONTOLOGY IDENTIFICATION Axiom to IMGT Standardized Keywords: For Immunoglobulins (IG), T Cell Receptors (TR), and Conventional Genes.
Lefranc, MP
) IMGT/JunctionAnalysis: IMGT Standardized Analysis of the V-J and V-D-J Junctions of the Rearranged Immunoglobulins (IG) and T Cell Receptors (TR).
Giudicelli, V., Lefranc, MP
IMGT/V-QUEST: IMGT Standardized Analysis of the Immunoglobulin (IG) and T Cell Receptor (TR) Nucleotide Sequences
Giudicelli, V., Brochet, X., Lefranc, MP
IMGT/Collier de Perles: IMGT Standardized Representation of Domains (IG, TR, and IgSF Variable and Constant Domains, MH and MhSF Groove Domains).
Ehrenmann, F., Giudicelli, V., Duroux, P., Lefranc, MP
IMGT/3Dstructure-DB: Querying the IMGT Database for 3D Structures in Immunology and Immunoinformatics (IG or Antibodies, TR, MH, RPI, and FPIA)
Ehrenmann, F., Lefranc, MP
IMGT/DomainGapAlign: IMGT Standardized Analysis of Amino Acid Sequences of Variable, Constant, and Groove Domains (IG, TR, MH, IgSF, MhSF).
Ehrenmann, F., Lefranc, MP
Analysis of somatic hypermutations of immunoglobulin gene rearrangements in childhood acute lymphoblastic leukemia
Braoudaki, M., Katsibardi, K., Giudicelli, V., Karamolegou, K., Papathanassiou, Ch., Lefranc, MP., Tzortzatou-Stathopoulou, F
Expression and genomic analyses of Camelus dromedarius T cell receptor delta (TRD) genes reveal a variable domain repertoire enlargement due to CDR3 diversification and somatic mutation
Antonacci, R., Mineccia, M., Lefranc, MP., Ashmaoui, HM., Lanave, C., Piccinni, B., Pesole, G., Hassanane, MS., Massari, S., Ciccarese, S.
Antibody nomenclature: From IMGT-ONTOLOGY to INN definition
Lefranc, MP.
Familial Mediterranean fever in a large Lebanese family: Multiple MEFV mutations and evidence for a Founder effect of the p.[M694I] mutation.
Medlej-Hashim, M., Chouery, E., Salem, N., Delague, V., Lefranc, G., Loiselet, J., Mégarbané, A.
Microsomal epoxide hydrolase gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in the Tunisian population.
Lakhdar R, Denden S, Knani J, Leban N, Daimi H, Hassine M, Lefranc G, Chibani JB, Khelil AH
Standardized sequence and structure analysis of antibody using IMGT®
Ehrenmann F., Duroux P., Giudicelli V. and Lefranc M.-P.
A Mise au point: déficit en alpha 1 antitrypsine. A review: alpha1 antitrypsin deficiency
Denden S., Lakhdar R., Leban N., Daimi H., El Hayek D., Knani J., Perrin P., Lefranc G., Ben Chibani J. and Haj Khelil A.
Atypical hemolytic uremic syndrome in the Tunisian population.
Leban, N., Aloui, S., Touati, D., Lakhdhar, R., Skhiri, H., Lefranc, G., Achour, A., Elmay, M., Lopez-Trascasa, M., Sanchez-Corral, P., Chibani, J., Haj Khelil, A.
Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide
Robert, R., Lefranc, MP., Ghochikyan, A., Agadjanyan, MG., Cribbs, DH., Van Nostrand, WE., Wark, KL., Dolezal, O.
Association of GSTM1 and GSTT1 polymorphisms with chronic obstructive pulmonary disease in a Tunisian population
Lakhdar, R., Denden, S., Knani, J., Leban, N., Daimi, H., Hassine, M., Lefranc, G., Ben Chibani, J., Haj Khelil, A.
ImmunoGrid: towards agent-based simulations of the human immune system at a natural scale.
Halling-Brown M, Pappalardo F, Rapin N, Zhang P, Alemani D, Emerson A, Castiglione F, Duroux P, Pennisi M, Miotto O, Churchill D, Rossi E, Moss DS, Sansom CE, Bernaschi M, Lefranc MP, Brunak S, Lund O, Motta S, Lollini PL, Murgo A, Palladini A, Basford KE, Brusic V, Shepherd AJ.
Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population
Lakhdar R, Denden S, Knani J, Leban N, Daimi H, Hassine M, Lefranc G, Ben Chibani J, Haj Khelil A.
From IMGT-ONTOLOGY to IMGT/LIGMotif: the IMGT(R) standardized approach for immunoglobulin and T cell receptor gene identification and description in large genomic sequences
Lane J, Duroux P, Lefranc MP.
A novel paradigm for cell and molecule interaction ontology: from the CMM model to IMGT-ONTOLOGY
Pappalardo, F., Lefranc, MP., Lollini, PL., Motta, S
Annotation and classification of the bovine T cell receptor delta genes
Herzig, CT., Lefranc, MP., Baldwin, CL.
Hemoglobinopathies in North Africa: a review.
Haj Khelil, A., Denden, S., Leban, N., Daimi, H., Lakhdhar, R., Lefranc, G., Ben Chibani, J., Perrin , P
IMGT/3D Structure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF
Ehrenmann, F., Kaas, Q., Lefranc, MP.
A new familial sclerosing bone dysplasia.
Chouery, E., Pangrazio, A., Frattini, A., Villa, A., Van Wesenbeeck, L., Piters, E., Van Hul, W., Coxon, F., Schouten, T., Helfrich, M., Lefranc, G., Mégarbané, A.
IMGT® standardized analysis of immunoglobulin rearranged sequences.
Giudicelli V. and Lefranc M.-P.
Antibody databases and tools: The IMGT® experience.
Lefranc MP.
Antibody databases: IMGT® a french platform of world-wide interest.
Lefranc, MP.
Protective effect of diclofenac towards the oxidative stress induced by paracetamol toxicity in rats
Aouacheri, W., Saka, S., Djafer, R., Lefranc, G
Biochemical and molecular diagnosis of alpha 1 antitrypsin deficiency in a Tunisian family
Denden S, Braham W, Amri F, Lakhdar R, Lefranc G, Knani J, Ben Chibani J, Haj Khelil A.
Alteration of sarcoplasmic reticulum ca release in skeletal muscle from calpain 3-deficient mice.
Dayanithi G, Richard I, Viero C, Mazuc E, Mallie S, Valmier J, Bourg N, Herasse M, Marty I, Lefranc G, Mangeat P, Baghdiguian S
Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity
Pelat T., Hust M., Hale M., Lefranc M.-P., Dübel S and Thullier P
Human Immunoglobulin Allotypes: Possible implications for immunogenicity
Jefferis, R and Lefranc, M.-P.
The deduced structure of the T cell receptor gamma locus in Canis lupus familiaris
Massari, S., Bellahcene, F., Vaccarelli, G., Carelli, G., Mineccia, M., Lefranc, MP., Antonacci, R., Ciccarese, S.
ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization.
Pappalardo, F., Halling-Brown, MD., Rapin, N., Zhang, P., Alemani, D., Emerson, A., Paci, P., Duroux, P., Pennisi, M., Palladini, A., Miotto, O., Churchill, D., Rossi, E., Shepherd, AJ., Moss, DS., Castiglione, F., Bernaschi, M., Lefranc, MP., Brunak, S., Motta, S., Lollini, PL., Basford, KE., Brusic, V.
IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab.
Magdelaine-Beuzelin C, Vermeire S, Goodall M, Baert F, Noman M, Assche GV, Ohresser M, Degenne D, Dugoujon JM, Jefferis R, Rutgeerts P, Lefranc MP, Watier H.
The B7 family of immunoregulatory receptors: A comparative and evolutionary perspective.
Hansen JD, Pasquier LD, Lefranc MP, Lopez V, Benmansour A, Boudinot P.
) IMGT(R), the international ImMunoGeneTics information system(R).
Lefranc, MP., Giudicelli, V., Ginestoux, C., Jabado-Michaloud, J., Folch, G., Bellahcene, F., Wu, Y., Gemrot, E., Brochet, X., Lane, J., Regnier, L., Ehrenmann, F., Lefranc, G., Duroux, P.
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis.
Brochet X, Lefranc MP, Giudicelli V
IMGT, the International ImMunoGeneTics Information System for Immunoinformatics : methods for querying IMGT databases, tools, and web resources in the context of immunoinformatics.
Lefranc MP
IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes.
Kaas, Q., Duprat, E., Tourneur, G. and Lefranc M.P
Admixture and sexual bias in the population settlement of La Réunion Island (Indian Ocean).
Berniell-Lee G, Plaza S, Bosch E, Calafell F, Jourdan E, Césari M, Lefranc G, Comas D
NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A.
Benayoun B, Baghdiguian S, Lajmanovich A, Bartoli M, Daniele N, Gicquel E, Bourg N, Raynaud F, Pasquier MA, Suel L, Lochmuller H, Lefranc G, Richard I
Novel and recurrent STAT3 mutations in hyper-IgE syndrome patients from different ethnic groups.
Jiao, H., Tóth, B., Erdős, M., Fransson, I., Rákóczi, E., Balogh, I., Magyarics, Z., Dérfalvi, B. Csorba, G., Szaflarska, A., Megarbane, A., Akatcherian, C., Dbaibo, G., Rajnavölgyi, E., Hammarström, L., Kere, J., Lefranc, G., Maródi, L
Alpha 1 antitrypsin polymorphism associated to asthma and emphysema in a central Tunisian population.
Haj-Khelil, A., Denden, S., Hlioui, L., Hattab, N., Daimi, H., Leban, N., Perrin, P, Lefranc, G., Ben Chibani, J.
IMGT-ONTOLOGY, IMGT® databases, tools and Web resources for Immunoinformatics.
Lefranc MP
WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report August 2007, 13th International Congress of Immunology, Rio de Janeiro, Brazil.
Lefranc MP
Alpha 1 antitrypsin polymorphism in the tunisian population with special reference to pulmonary disease
Denden, S., Haj Khelil, A., Perrin, P., Daimi, H., Leban, N., Ouaja, A., Mahdouani, K., Hlioui, L., Lefranc, G., Ben Chibani, J.
IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm
Duroux, P., Kaas, Q., Brochet, X., Lane, J., Ginestoux, C., Lefranc, MP., Giudicelli, V.
IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics
Lefranc, MP., Giudicelli, V., Regnier, L., Duroux, P.
Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering.
Pelat T, Bedouelle H, Rees AR, Crennell SJ, Lefranc MP, Thullier P.
Recovering probabilities for nucleotide trimming processes for T cell receptor TRA and TRG V-J junctions analyzed with IMGT tools
Bleakley, K., Lefranc, MP., Biau, G.
IMGT Colliers de Perles for IgSF domain standardization: The T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA4, PDCD1 and BTLA) receptors
Garapati V.P. and Lefranc M.-P.
Genetic diseases in consanguineous families: Invaluable contribution to the fundamental research
Lefranc G
IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?
Kaas, Q., Ehrenmann, F., Lefranc, MP.
WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report
Lefranc MP
Electron microscopic findings in skin biopsies from patients with infantile osteopetrosis and neuronal storage disease
Alroy, J., Pfannl, R., Ucci, A., Lefranc, G., Frattini, A., Mégarbané, A.
Le paradigme IMGT-ONTOLOGY
Giudicelli V. and Lefranc M.-P.
A high affinity, human-like antibody fragment (scFv) neutralising the lethal factor (LF) of Bacillus anthracis by inhibiting PA-LF complex formation
Pelat T., Hust M., Laffly E., Condemine F., Bottex C., Vidal D., Lefranc M.-P., Dubel S. and Thullier P.
C3 complement polymorphism in patients suffering from obstructive chronic bronchopneumopathy in Tunisia
Leban, N., Haj Khelil, A., Daimi, H., Denden, S., Slimene, F., Mehdouani, K., Abdennaji Guenounou, B., Lefranc, G., Perrin, P., Ben Chibani, J.
Costimulatory receptors in jawed vertebrates: conserved CD28, odd CTLA4 and multiple BTLAs
Bernard, D., Hansen, JD., Du Pasquier, L., Lefranc, MP., Benmansour, A., Boudinot, P.
IMGT Colliers de Perles and IgSF domain standardization for T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA4, PDCD1 and BTLA) receptors
Garapati, VP., Lefranc, MP.
Molecular study of six families originating from the Middle-East and presenting with autosomal recessive osteopetrosis.
Souraty N, Noun P, Djambas-Khayat C, Chouery E, Pangrazio A, Villa A, Lefranc G, Frattini A, Megarbane A.
Structure-function relationships of the variable domains of monoclonal antibodies approved for cancer treatment
Magdelaine-Beuzelin, C., Kaas, Q., Wehbi, V., Ohresser, M., Jefferis, R., Lefranc, M.P., Watier, H.
IMGT®, the international ImMunoGeneTics information system® for immunoinformatics. Methods for querying IMGT® databases, tools and Web resources in the context of immunoinformatics.
Lefranc , M.P.
Interactive IMGT on-line database and tool for the structural analysis of immunoglobulins, T cell receptors, MHC and related proteins of the immune system
Kaas, Q. and Lefranc, M.P.
IMGT Colliers de Perles: standardized sequence-structure representations of the IgSF and MhcSF superfamily domains
Kaas, Q., Lefranc, MP.
The genomic sequence of the bovine T cell receptor gamma TRG loci and localization of the TRGC5 cassette.
Conrad, ML., Mawer, MA., Lefranc, MP., McKinnell, L., Whitehead, J., Davis, SK., Pettman, R., Koop, BF.
Diversity in the Complementarity Determining Region 3 (CDR3) of Antibodies from mice with evolving anti-TSHR antibody responses.
Martinez O, Gangi E, Mordi D, Gupta S, Dorevitch S, Lefranc MP, Prabhakar BS.
IMGT®, the international ImMunoGeneTics information system®, the reference in immunogenetics and immunoinformatics. In: Proceedings First International Congress on Macromolecular Biochemistry and Genetics. Gafsa, Tunisia, 12-16 April 2007.
Duroux P., Giudicelli V., Kaas Q., Jabado-Michaloud J., Folch G., Ginestoux C., Brochet X., Lane J., Régnier L. Wu Y., Garapati V.P., Bellahcene F., Servier E.-J., Ehrenmann F., Lefranc G and Lefranc M.-P.
IMGT standardization for statistical analyses of T cell receptor junctions: the TRAV-TRAJ example
BLEAKLEY K., GIUDICELLI V., WU Y., LEFRANC M.-P. and BIAU G
Chemiluminescent detection of clonal immunoglobulin and T cell receptor gene rearrangements in Tunisian lymphoid malignancies, leukemias and lymphomas.
Abed R.E., Khechine A.E., Omri H.E., Youssef S., Laatiri A., Lefranc M.-P., Khelif A., Soua Z
IMGT/GeneInfo: T cell receptor gamma TRG and delta TRD genes in database give access to all TR potential V(D)J recombinations
Baum T.P., Hierle V., Pascal N., Bellahcene F., Chaume D., Lefranc M.-P., Jouvin-Marche E., Marche P.N. and Demongeot J.
Mutations in OSTM1 (Grey Lethal) define a particular severe form of autosomal recessive osteopetrosis with neural involvement.
Pangrazio A., Poliani P.L., Mégarbané A., Lefranc G., Lanino E., Di Rocco M., Rucci F., Lucchini F., Ravanini M., Facchetti F., Abinun M., Vezzoni P., Villa A. and Frattini A.
Using bioinformatics tools for the sequence analysis of the immunoglobulins and T cell receptors.
Lefranc M.-P.
Web sites of Interest to Immunologists.
Lefranc M.-P.
Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating T cells
Herzig C., Blumerman S., Lefranc M.-P. and Baldwin C.
PenBase, the shrimp antimicrobial peptide penaeidin database: sequence-based classification and recommended nomenclature.
Gueguen, Y., Garnier, J., Robert, L., Lefranc, M.-P., Mougenot, I., de Lorgeril, J., Janech, M., Gross, P., Warr, G., Cuthbertson, B., Barracco, M.A., Bulet, P., Aumela, A., Yang, Y., Bo, D., Xiang, J., Tassanakajon, A., Piquemal, D. and Bachère, E
IMGT/LIGM-DB, the IMGT® comprehensive database of immunoglobulin and T cell receptor nucleotide sequences.
Giudicelli V., Duroux, P., Ginestoux C., Folch G., Jabado-Michaloud J., Chaume D. and Lefranc, M.-P.
A simple method to predict protein-binding from aligned sequences--application to MHC superfamily and beta2-microglobulin
Duprat, E, Lefranc, MP, Gascuel, O.
Population structure in the Mediterranean basin: a Y chromosome perspective
Capelli C, Redhead N, Romano V, Cali F, Lefranc G, Delague V, Megarbane A, Felice AE, Pascali VL, Neophytou PI, Poulli Z, Novelletto A, Malaspina P, Terrenato L, Berebbi A, Fellous M, Thomas MG, Goldstein DB.
HLA-C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India-Pakistan
Buhler, S., Mégarbané, A., Lefranc, G., Tiercy, J.M. and Sanchez-Mazas, A.
Retrieving factual data and documents using IMGT-ML in the IMGT information system®
Chaume D. Combres K., Giudicelli V. and Lefranc M.-P.
IMGT-ONTOLOGY and IMGT databases, tools and Web resources for Immunoinformatics. From the IMGT genomics, genetics and structural approaches to IMGT-Choreography
Lefranc MP.
IMGT, the international ImMunoGeneTics information system®: a standardized approach for immunogenetics and immunoinformatics
Lefranc, M.-P.
T cell receptor/peptide/MHC molecular characterization and standardized pMHC contact sites in IMGT/3Dstructure-DB
Kaas, Q. and Lefranc, M.-P.
IMGT unique numbering for standardized contact analysis of immunoglobulin/antigen and T cell receptor/peptide/MHC complexes
Kaas, Q., Chiche, L. and Lefranc, M.-P.
MICA: standardized IMGT allele nomenclature, polymorphisms and diseases
Frigoul, A. and Lefranc, M.-P.
Selection of a macaque Fab with human-like framework regions, high affinity, and that neutralizes the protective antigen (PA) of Bacillus anthracis
Laffly, E., Danjou, L., Condemine, F., Vidal, D., Drouet, E., Lefranc, M.-P., Bottex, C. and Thullier, P.
Immunogenetics sequence annotation: the strategy of IMGT based on IMGT-ONTOLOGY
Giudicelli, V., Chaume, D., Jabado-Michaloud, J. and Lefranc, M.-P.
Interactive IMGT on-line tools for the analysis of immunoglobulin and T cell receptor repertoires
Giudicelli, V. and Lefranc, M.-P.
IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN
Lefranc, M.-P., Duprat, E., Kaas, Q., Tranne, M., Thiriot, A. and Lefranc, G.
IMGT-Choreography: processing of complex immunogenetics knowledge
Chaume, D., Giudicelli, V., Combres, K., Ginestoux, C. and Lefranc, M.-P.
IMGT-Choreography for Immunogenetics and Immunoinformatics
Lefranc, M.-P., Clément, O., Kaas, Q., Duprat, E., Chastellan, P., Coelho, I., Combres, K., Ginestoux, C., Giudicelli, V., Chaume, D. and Lefranc, G.
IMGT, the international ImMunoGeneTics information system®
Lefranc, M.-P., Giudicelli, V., Kaas, Q., Duprat, E., Jabado-Michaloud, J., Scaviner, D., Ginestoux, C., Clément, O., Chaume, D., Lefranc, G.
IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes
Giudicelli, V., Chaume, D. and Lefranc, M.-P.
IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains
Lefranc, M.-P., Pommié, C., Kaas, Q., Duprat, E., Bosc, N., Guiraudou, D., Jean, C., Ruiz, M., Da Piedade, I., Rouard, M., Foulquier, E., Thouvenin, V. and Lefranc, G.
Familial Mediterranean fever (FMF) in Lebanon and Jordan: a population genetics study and report of three novel mutations.
Medlej-Hashim M, Serre JL, Corbani S, Saab O, Jalkh N, Delague V, Chouery E, Salem N, Loiselet J, Lefranc G, Mégarbané A.
IMGT-Choreography: processing of complex immunogenetics knowledge.
Chaume, D., Giudicelli, V., Combres, K., Ginestoux, C. and Lefranc, M.P
[Familial Mediterranean Fever (FMF): from diagnosis to treatment].
Medlej-Hashim M, Loiselet J, Lefranc G, Mégarbané A
IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily
Duprat E., Kaas Q., Garelle V., Lefranc G. and Lefranc M.-P.
IMGT, the international ImMunoGeneTics information system®
Lefranc, M-P.
IMGT/JunctionAnalysis : the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs
Yousfi Monod M., Giudicelli V., Chaume D. and Lefranc M.-P.
A high affinity macaque antibody Fab with human-like framework regions obtained from a small immune phage display library.
Chassagne, S., Laffly, E., Drouet, E., Herodin, F., Lefranc, M.-P. and Thullier, P.
IMGT/V-QUEST, an integrated software for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis.
Giudicelli V., Chaume D. and Lefranc M.-P.
Characterization of human FCGR3B*02 (HNA-1b, NA2) cDNAs and IMGT standardized description of FCGR3B alleles
Bertrand, G., Duprat, E., Lefranc, M.-P., Marti, J. and Coste, J.
Immunoglobulin lambda (IGL) genes of human and mouse
Lefranc, M.-P. and Lefranc, G.
IMGT/GeneInfo: enhancing V(D)J recombination database accessibility
Baum, P., Pasqual, N., Thuderoz, F., Hierle, V., Chaume, D., Lefranc, M.-P., Jouvin-Marche, E., Marche, N., and Demongeot, J.
IMGT-ONTOLOGY and IMGT databases, tools and web resources for immunogenetics and immunoinformatics
Lefranc, M.-P.
IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, t cell receptor and MHC structural data.
Kaas, Q., Ruiz, M. and Lefranc, M.-P.
Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) syndrome: report of a new family with additional features and review
Mégarbané, H., Zablit, C., Waked, N., Lefranc, G., Tomb, R. and Mégarbané, A.
IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties
Pommié, C., Levadoux, S., Sabatier, R., Lefranc, G. and Lefranc, M.-P.
Amyloidosis in familial Mediterranean fever patients: correlation with MEFV genotype-phenotype correlation and SAA1 and MICA polymorphisms effects
Medlej-Hashim, M., Delague, V., Chouery, E., Salem, N., Rawashdeh, M., Lefranc, G., Loiselet, J., and Mégarbané, A.
IMGT-ONTOLOGY for Immunogenetics and Immunoinformatics (http://imgt.cines.fr)
Lefranc, M.-P., Giudicelli, V., Ginestoux, C., Bosc, N., Folch, G., Guiraudou, D., Jabado-Michaloud, J., Magris, S., Scaviner, D., Thouvenin, V., Combres,K., Girod, D., Jeanjean, S., Protat, C., Yousfi-Monod, M., Duprat, E., Kaas, Q., Pommié, C., C
IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains
Lefranc, M.-P., Pommié, C., Ruiz, M., Giudicelli, V., Foulquier, E., Truong, L., Thouvenin-Contet, V. and Lefranc, G.
IMGT® databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr
Lefranc, M.-P.
IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr: the reference in immunoinformatics.
Lefranc, M.-P., Giudicelli, V., Ginestoux, C. and Chaume, D.
IMGT, the international ImMunoGeneTics information system®, http://imgt.cines.fr -
Lefranc, M.-P.
Local application of IGF1 on dental pulp mechanically exposed; in vivo study on rabbit
Haddad, M., Lefranc, G. and Aftimos, G.
Joining the pillars of Hercules: mtDNA sequences show multidirectional gene flow in the Western Mediterranean
Plaza, S., Calafell, F., Helal, A., Bouzerna, N., Lefranc, G., Bertranpetit, J. and Comas, D.
Editorial - The International ImMunoGeneTics database IMGT
Warr, G.W., Clem, L.W. and Söderhall, K.
IMGT/PhyloGene: an online software package for phylogenetic analysis of immunoglobulin and T cell receptor genes
Elemento, O and Lefranc, M.-P.
IMGT-ONTOLOGY: gestion et découverte de connaissances au sein d'IMGT
Giudicelli, V. and Lefranc, M.-P.
IMGT Locus in Focus: The mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes
Bosc, N. and Lefranc, M.-P.
IMGT, the international ImMunoGeneTics database®, http://imgt.cines.fr
Lefranc, M.-P.
An efficient and accurate distance based algorithm to reconstruct tandem duplication trees
Elemento, O. and Gascuel, O.
Evidence for Balancing Selection from Nucleotide Sequence Analyses of Human G6PD
Verrelli, B.C., McDonald, J.H., Argyropoulos, G., Destro-Bisol, G., Froment, A., Drousiotou, A., Lefranc, G., Helal, A.N., Loiselet, J. and Tishkoff, S.A.
Asymptomatic deficiency in the peptide transporter associated to antigen processing (TAP)
De la Salle, H., Saulquin, X., Mansour, I., Klaymé, S., Fricker, D., Zimmer, J., Cazenave, J-P., Hanau, D., Bonneville, M., Houssaint, E., Lefranc, G. and Naman, R.
IMGT, the international ImMunoGeneTics database : a high-quality information system for comparative immunogenetics and immunology
Lefranc, M-P
The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases
Chardes, T., Chapal, N., Bresson, D., Bes, C., Giudicelli, V., Lefranc, M-P and Peraldi-Roux, S.
Reconstructing the duplication history of tandemly repeated genes
Elemento, O., Gascuel, O. and Lefranc, M-P.
IMGT gene identification and Colliers de Perles of human immunoglobulin with know 3D structures
Ruiz, M. and Lefranc, M-P.
Consanguinity
Lefranc, M.-P. and Lefranc, G.
Familial mediterranean fever: the potential for misdiagnosis of E148V using the E148Q usual RFLP detection method
Medlej-Hashim, M., Salem, N., Chouery, E., Rawashdeh, M., Delague, V., Haffar, M., Mansour, I., Naman, R., Lefranc, G., Loiselet, J. and Megarbané A.
Nomenclature and overview of the mouse (Mus musculus and Mus sp.) immunoglobulin kappa (IGK) genes
Martinez-Jean C., Folch, G. and Lefranc, M.-P.
Familial mediterranean fever: association of elevated IgD plasma levels with specific MEFV mutations
Medlej-Hashim, M., Petit, I., Adib, S., Chouery, E., Salem, N., Delague, V., Rawashdeh, M., Mansour, I., Lefranc, G., Naman, R., Loiselet, J., Lecron, J.-C., Serre, J.-L. and Megarbané A.
Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance
Tishkoff, S.A., Varkonyi, R., Cahinhinan, N., Abbes, S., Argyropoulos, G., Destro-Bisol, G., Drousiotou, A;, Dangerfield, B., Lefranc, G., Loiselet, J., Piro, A., Stoneking, M., Tagarelli, A., Tagarelli, G., Touma, E.H., Williams, S.M. and Clark, A.G
IMGT-XML a XML language for IMGT-ONTOLOGY and IMGT/LIGM-DB data
Chaume, D., Giudicelli, V. and Lefranc, M.-P.
DNA sequence variability of IGHG3 genes associated to the main G3m haplotypes in human populations
Dard, P., Lefranc, M.-P., Osipova, L., Sanchez-Mazas, A.
The T cell Receptor FactsBook
Lefranc, M.-P., and Lefranc, G.
The Immunoglobulin FactsBook
Lefranc, M.-P., and Lefranc, G.
IGHV3 associated restriction fragment length polymorphisms confer susceptibility to bullous pemphigoid
Raux, G., Gilbert, D., Joly, P., Martel, P., Roujeau, J.-C., Prost, C., Lefranc, M.-P., Tron, F.
Nomenclature of the human immunoglobulin lambda (IGL) genes
Lefranc, M.-P.
Pathophysiology of limb girdle muscular dystrophy type 2A: hypothesis and new insights in the IkappaBalpha/NF-kappaB survival pathway
Baghdiguian, S., Richard, I., Martin, M., Coopman, P., Beckmann, J.S., Mangeat, P., Lefranc, G.
IMGT, the International ImMunoGeneTics database.
Lefranc, M.-P.
A study of GM allotypes and gamma immunoglobulins heavy chain genes in Berbers, Arabs and sub-Saharan Africans from the Jerba Island (Tunisia)
Yacoubi Loveslati, B., Sanchez-Mazas, A., Ennafaa, H., Marrakchi, R., Dugoujon, J.-M., Lefranc, M.-P., Ben Ammar Elgaaied, A.
Nomenclature of the human immunoglobulin heavy (IGH) genes
Lefranc, M.-P.
Nomenclature of the human immunoglobulin kappa (IGK) genes
Lefranc, M.-P.
Familial Mediterranean Fever in Lebanon: mutation spectrum, evidence for cases in Maronites, Greek Orthodoxes, Greek Catholics, Syriacs and Chiites and for an association between Amyloidosis and M694V and M694I mutations
Mansour, I., Delague, V., Cazeneuve, C., Dode, C., Chouery, E., Pecheux, C., Medlej-Hachim, M., Salem, N., Al Zein, L., Levan-Petit, I., Lefranc, G., Goossens, M., Delpech, M., Amselem, S., Megarbane, A., Grateau, G., Loiselet, J. and Naman, R.
A worldwide analysis of AG molecular diversity inferred from serology
Sanchez-Mazas, A., Bütler-Brunner, E., Bütler, R., Calderon, R., Chaventre, A., Dugoujon, J.-M.,Hammond, M., Lefranc, G., Matsumoto, H., Osipova, L., Politis, C., Pullman, R. and Langaney, A.
The Mouse (Mus musculus) T cell Receptor Delta Variable (TRDV), Diversity (TRDD), and Joining (TRDJ) Genes
Bosc, N., Contet, V. and Lefranc, M.-P.
Characterisation and specificity of two single-chain Fv antibodies directed to the protein tyrosine kinase Syk
Péneff, C., Lefranc M.-P. and Dariavach, P.
Genetic screening of fourteen mutations in jordanian familial mediterranean fever patients
Medlej-Hashim, M., Rawashdeh, M., Chouery, E., Mansour, I., Delague, V., Lefranc, G., Naman, R., Loiselet, J. and Mégarbané, A.
Protein displays of the Human T cell Receptor Alpha, Beta, Gamma and Delta Variable and Joining Regions
Folch, G., Scaviner, D., Contet, V. and Lefranc, M.-P.
Locus Maps and Genomic Repertoire of the Human T cell Receptor Genes
Lefranc, M.-P.
Locus Maps and Genomic Repertoire of the Human Immunoglobulin Genes
Lefranc, M.-P.
The Teleostei Immunoglobulin Light IGL1 and IGL2 V, J and C Genes
Artero, S. and Lefranc, M.-P.
The Teleostei Immunoglobulin Heavy IGH Genes
Artero, S. and Lefranc, M.-P.
The Human T cell Receptor Beta Diversity (TRBD) and Beta Joining (TRBJ) Genes
Folch, G. and Lefranc, M.-P.
The Human T cell Receptor Alpha Joining (TRAJ) Genes
Scaviner, D. and Lefranc, M.-P.
Nomenclature of the human T cell Receptor genes
Lefranc, M.-P.
Nomenclature of the human immunoglobulin genes
Lefranc, M.-P.
Web sites of Interest to Immunologists
Lefranc, M.-P.
IMGT (ImMunoGénéTique), base de données internationale spécialisée et intégrée en Immunogénétique
Giudicelli, V., Chaume, D. and Lefranc M-P.
IMGT, the international ImMunoGeneTics database.
Ruiz, M., Giudicelli, V., Ginestoux, C., Stoehr, P., Robinson, J., Bodmer, J., Marsh, S.G., Bontrop, R., Lemaitre, M., Lefranc, G., Chaume, D. and Lefranc, M.-P.
The human T cell Receptor Alpha Variable (TRAV) Genes.
Scaviner, D. and Lefranc, M.-P.
The human T cell receptor beta variable (TRBV) genes.
Folch, G. and Lefranc, M.-P.
IMGT sequence profile: a standardized visualization for the immunoglobulin and T cell receptor V-REGIONs applicable to other protein alignments
Ruiz, M. and Lefranc, M.-P.
Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/NF-kappaB pathway perturbation in mice
Richard, I., Roudaut, C., Marchand, S., Baghdiguian, S., Herasse, M., Stockholm, D., Ono, Y., Suel, L., Bourg, N., Sorimachi, H., Lefranc, G., Fardeau, M., Sebille, A. and Bexkmann, J.S.
The Mouse (Mus musculus) T cell Receptor Beta Variable (TRBV), Diversity (TRBD), and Joining (TRBJ) Genes
Bosc, N. and Lefranc, M.-P.
IMGT ImMunoGeneTics Database
Lefranc, M.-P.
Alu insertion polymorphisms in Northwest Africa and the Iberian Peninsula: evidence for a strong genetic boundary through the Gilbraltar Straits
Comas, D., Calafell, F., Benchemsi, N., Helal, A., Lefranc, G., Stoneking, M., Batzer, M.A., Bertranpetit, J. and Sajantila, A.
Towards database interoperability, ontologies and biological data mining
Chaume, D.
Calpaïne 3 et dystrophie musculaire des ceintures de type 2A
Herasse, M., Baghdigian, S., Fougerousse, F., Martin, M., Stockhlom, D., Beckmann, J.S., Lefranc, G. and Richard, I.
Protein displays of the human immunoglobulin heavy, kappa and lambda variable and joining regions.
Scaviner, D., Barbié, V., Ruiz, M. and Lefranc, M.-P.
The Human Immunoglobulin Heavy Diversity (IGHD) and Joining (IGHJ) segments.
Ruiz, M., Pallarès, N., Contet, V., Barbie, V. and Lefranc, M.-P.
IMGT, base de données internationale en ImMunoGénétique, http://imgt.cnusc.fr:8104.
Ruiz, M., Giudicelli, V. and Lefranc, M.-P.
The human immunoglobulin heavy variable (IGHV) genes.
Pallarès, N., Lefebvre, S., Contet, V., Matsuda, F. and Lefranc, M.-P.
BamHI-SacI RFLP and Gm analysis of the immunoglobulin IGHG genes in the Northern Selkups (West Siberia) : new haplotypes with deletion, duplication and triplication.
Osipova, L.P., Posukh, O.L., Wiebe, V.P., Miyazaki, T., Matsumoto, H., Lefranc, G. and Lefranc, M.-P.
Allelic polymorphisms and RFLP in the human immunoglobulin lambda light chain locus.
Lefranc, M.-P., Pallarès, N. and Frippiat, J.-P.
IMGT, the international ImMunoGeneTics database.
Lefranc, M.-P., Giudicelli, V., Ginestoux, C., Bodmer, J., Müller, W., Bontrop, R., Lemaître, M., Malik, A., Barbié, V. and Chaume, D.
Trends and challenges of Bioinformatics.
Lefranc, M.-P.
The IMGT unique numbering for Immunoglobulins, T cell receptors and Ig-like domains.
Lefranc, M.-P.
Ontology for Immunogenetics : IMGT-ONTOLOGY.
Giudicelli, V. and Lefranc, M.-P.
Towards database interoperability, ontologies and biological data mining.
Chaume, D.
Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IB/NF-B pathway in limb-girdle muscular dystrophy type 2A.
Baghdiguian, S., Martin, M., Richard, I., Pons, F., Astier, C., Bourg, N., Hay, R., Chemaly, R., Halaby, G., Loiselet, J., Anderson, L., Lopez de Munain, A., Fardeau, M., Mangeat, P., Beckmann, J. and Lefranc, G.
Présentation à la surface du phage filamenteux : les multiples applications du phage display.
Souriau, C., Hua, T.D., Lefranc, M.-P. and Weill, M.
A genetic study of the south Altaian population of the Mendur-Sokkon village, Altai Republic.
Posukh, O.L., Osipova, L.P., Kashinskaya, Y.O., Ivakin, E.A., Kryukov, Y.A., Karafet, T.M., Kazakovtseva, M.A., Skobel'Tsina, L.M., Crawford, M.G., Lefranc, M.-P. and Lefranc, G.
IMGT Locus on Focus - The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments.
Pallares, N., Frippiat, J.P., Giudicelli, V. and Lefranc, M.-P.
The mouse (Mus musculus) immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments.
Martinez, C. and Lefranc, M.-P.
PreB1 (CD10-) acute lymphoblastic leukaemia : immunophenotypic and genomic characteristics, clinical features and outcome in 38 adults and 26 children.
Lenormand, B., Béné, M.C., Lesesve, J.F., Bastard, C., Tilly, H., Lefranc, M.-P., Faure, G.-C., Garand, R., Falkenrodt, A., Kandel, G., Solary, E., Maynadié, M., Callat, M.-P., Thouret, F., Monconduit, M., Vannier, J.-P. and The Groupe d'Etude Immuno
IMGT, the International ImMunoGeneTics database.
Lefranc, M.-P., Giudicelli, V., Busin, C., Bodmer, J., Muller, W., Bontrop, R., Lemaitre, M., Malik, A. and Chaume, D.
Quelle génétique demain
Lefranc, M.-P.
IMGT, the international ImMunoGeneTics database, http://imgt.cnusc.fr:8104.
Lefranc, M.-P.
IMGT Locus on Focus : a new section of Experimental and Clinical Immunogenetics.
Lefranc, M.-P.
Detection of antigen receptor gene rearrangements in lymphoproliferative malignancies by fluorescent polymerase chain reaction.
Kerlan-Candon, S., Soua, Z., Lefranc, M.-P., Clot, J. and Eliaou, J.-F.
Role of JAK3 in CD40-mediated signaling.
Jabara, H.H., Buckley, R.H., Roberts, J.L., Lefranc, G., Loiselet, J., Khalil, G. and Geha, R.S.
IMGT, the international ImMunoGeneTics database: a new Design for Immunogenetics Data Access
Giudicelli, V., Chaume, D., Mennessier, G., Althaus, H.-H., Müller, W., Bodmer, J., Malik, A. and Lefranc, M.-P.
IMGT/LIGM-DB : a systematized approach for ImMunoGeneTics database coherence and data distribution improvement.
Giudicelli, V., Chaume, D. and Lefranc, M.-P.
Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation : implications for treatment.
Bozzi, F., Lefranc, G., Villa, A., Badolato, R., Schumacher, R.F., Khalil, G., Loiselet, J., Bresciani, S., O'Shea, J.J., Vezzoni, P., Notarangelo, L.D. and Candotti, F.
Influence of Intron lenght and its influence on Alternative Splicing of CD44.
Bell, M.V., Cowper, A.E., Lefranc, M.-P., Bell, J.I. and Screaton, G.R.
IMGT/PRIMER-DB (http://imgt.cnusc.fr:8104) - Une base de données pour la construction de banques combinatoires de fragments d'anticorps et de peptides.
Barbié, V., Lemaitre, M. and Lefranc, M.-P.
The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments.
Barbié, V. and Lefranc, M.-P.
Thèses en cours
Sujet : Etude génomique et biocuration des loci des récepteurs d'antigènes chez les espèces de vertébrés à mâchoires impliqués dans la recherche biotechnologique
Direction de thèse de Madame DEBBAGH CHAHRAZED (thèse 1A 2020-2023 )
Directrice de thèse : Sofia KOSSIDA 25%
Encadrants : Veronique GIUDICELLI 25%, Geraldine FOLCH 25%, Joumana JABADO-MICHALOUD 25%
Financement : bourse d’excellence d’Algérie
Sujet : l'Intelligence artificielle appliquée à l'immunogénétique
Direction de thèse de Monsieur ELAZAMI ELHASSANI Merouane (thèse 2A 2020-2023 )
Directrice de thèse: Sofia KOSSIDA 25%,
Encadrants: Loïc MAISONNASSE 50% (ATOS), Patrice Duroux 25%
Financement : bourse CIFRE avec ATOS
Sujet : Explorer et visualiser la réponse immunitaire spécifique après immunisation, VISIMMU
Direction de thèse de Madame GORET Agathe (thèse 1A 2020-2023 )
Directrice de thèse: Sofia KOSSIDA 25%,
Encadrants: Catherine PRADES 25% (SANOFI), Veronique GIUDICELLI 25%, Patrice DUROUX 25%
Financement : bourse CIFRE avec SANOFI
Sujet : Approche IMGT pour la prédiction et l'analyse de l'interaction épitope et paratope
par Anjana Kushwaha
Direction de thèse de Madame KUSHWAHA Anjana (thèse 1A 2020-2023 )
Directeurs de thèse: Sofia KOSSIDA 25%, Konstantin TODOROV 25% (LIRMM),
Encadrants: Veronique GIUDICELLI 25%, Patrice DUROUX 25%
Financement : co-financement de la Région
Sujet : Une base de connaissance en immunogénétique pour la découverte de la nouvelle connaissance scientifique au sein d'IMGT®
Direction de thèse de Monsieur SANOU Gaoussou (thèse 1A 2020-2023 )
Directeurs de thèse: Sofia KOSSIDA 25%, Konstantin TODOROV 25% (LIRMM),
Encadrants: Veronique GIUDICELLI 25%, Patrice DUROUX 25%
Financement : contrat doctoral CBS2
Sujet : Caractérisation in silico des répertoires des gènes des immunoglobulines et des récepteurs des cellules T chez des souches consanguines de Mus musculus
par Anna Tran
Direction de thèse de Madame TRAN Anna (thèse 2A 2020-2023 )
Directrice de thèse: Sofia KOSSIDA 25%,
Encadrants: Veronique GIUDICELLI 25%, Geraldine FOLCH 50%
Financement : ressources propres d’IMGT
Thèses dirigées par Marie-Paule Lefranc et Gérard Lefranc : http://www.imgt.org/about/aboutus.php#thesis