Yang, Chami et al. show that loss of the exonuclease TREX1 in murine cancer cells stabilizes short MRE11-dependent cytosolic DNA fragments. These fragments activate interferon signaling and promote anti-tumor immunity, enhancing PD-1 blockade responses and immune memory.

Yang, Chami et al. EMBO reports 2026 https://doi.org/10.1038/s44319-026-00961-8

Philippe Pasero - Maintenance of genome integrity during DNA replication