Projet : To analyze mRNA regulation by piRNAs in stem cell biology

We are using Drosophila germline stem cells (GSCs), an outstanding model to study stem cells in vivo.

We have demonstrated a role of Aub in GSC self-renewal and this Aub function depends on the regulation of the proto-oncogene Cbl (Rojas-Rios et al. EMBO J. 2017).

We are further investigating the role of Aub and piRNAs in mRNA regulation for stem cell self-renewal and differentiation.

 

Figure : Scheme of mRNA regulation by Aubergine and piRNAs in Drosophila germline stem cells.