Projet : To analyze the molecular mechanisms of mRNA regulation by piRNAs and PIWI proteins
We have shown that the PIWI protein Aubergine (Aub) plays a role in the stability of maternal mRNAs in the embryo: it is involved in both the decay of maternal mRNAs in the somatic part of the embryo, and the stabilization of the same mRNAs in the germ plasm -a specialized cytoplasm at the posterior pole of the embryo, from which the germline develops-.
Recently, we have identified a new function of Aub in the translational control of maternal mRNAs.
We are analyzing this new function.
mRNA modification or “epitranscriptomics” has emerged has a new layer of gene regulation.