Molecular Basis of Inflammation

Molecular bases of human diseases

Inflammation is a normal reaction of the immune system in response to infections or tissue damage. It plays a pivotal role in triggering adaptive immune responses. However, unresolved inflammation is pervasive and fosters several etiologically distinct human pathologies that present with a broad range of symptoms. Such pathologies include cancer, auto-inflammatory and auto-immune disorders, but also metabolic diseases.

The Molecular Basis of Inflammation team studies the molecular mechanisms involved in the initiation, maintenance, and resolution of inflammation. To decipher how deregulation of these processes promote pathologies, we study inflammatory responses at several scales:

  • At the molecular level: we identify and characterize new pathways involved in triggering inflammatory pathologies,
  • At the cellular level: we characterize how these pathways are regulated depending on cellular identity,
  • At the tissue level: we study how cellular heterogeneity within tissues dictates the outcome of inflammatory response and impacts homeostasis
  • At the organism level: we study inflammatory responses and the consequences of their pathological activation on integrated in vivo models .


To achieve these aims, the Molecular Basis of Inflammation team uses and develops techniques ranging from nanotechnologies, single-cell transcriptomics, to in vivo phenotyping. We develop interdisciplinary approaches around these themes through networks and collaborations at national (https://www.innasco.fr/) and international (https://frontinov.cnrs.fr/) levels.

The “Molecular Basis of Inflammation” team welcomes applications from research scientists and engineers willing to implement new technologies in a fast-evolving area of research.
Contact: Nadine.Laguette@igh.cnrs.fr

Nadine LAGUETTE
Researcher

0434359811
Robin Charpentier
Robin CHARPENTIER
Assistant ingénieur en biologie
IT

0434359811
Klaudia Kvakova
Klaudia KVAKOVA
Postdoc invité
Postdoc

0434359811
Moritz Schüssler
Moritz SCHüSSLER
Postdoc
Postdoc

0434359811
Clara TAFFONI
Postdoc

0434359811
Hanane CHAMMA
PhD Student

0434359811
Tommy Chastel
Tommy CHASTEL
PhD Student
PhD Student

0434359811
Soumyabrata GUHA
PhD Student

0434359945

PUBLICATIONS OF THE TEAM

Regulation of innate immunity by Nrf2

van der Horst D, Carter-Timofte ME, van Grevenynghe J, Laguette N, Dinkova-Kostova AT, Olagnier D

more

Alternative pathways driven by STING: From innate Immunity to lipid metabolism.

Vila IK, Guha S, Kalucka J, Olagnier D, Laguette N.

The crosstalk between DNA-PK and cGAS drives tumor immunogenicity

Clara Taffoni, Johanna Marines, Hanane Chamma, Mathilde Saccas, Amel Bouzid, Soumyabrata Guha, Ana-Luiza Chaves Valadao, Katarzyna Polak, Maguy Del Rio, Celine Gongora, Donovan Pineau, Jean-Philippe Hugnot, Karima Kissa, Laura Fontenille, Fabien P. Blanchet, Isabelle K. Vila, Nadine Laguette

more

Protocol to induce and assess cGAS-STING pathway activation in vitro.

Chamma H, Guha S, Laguette N, Vila IK

Activation of STING in the pancreatic tumor microenvironment: A novel therapeutic opportunity

Hanane Chamma, Isabelle K Vila, Clara Taffoni, Andrei Turtoi, Nadine Laguette

STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

Isabelle K.Vila, Hanane Chamma, Alizée Steer, Mathilde Saccas, Clara Taffoni, Evgenia Turtoi, Line S.Reinert, Saqib Hussain, Johanna Marines, Lei Jin, Xavier Bonnefont, Mathieu Hubert, Olivier Schwartz, Soren R.Paludan, Gaetan Van Simaeys, Gilles Doumont, Bijan Sobhian, Dimitrios Vlachakis, Andrei Turtoi, Nadine Laguette

more

Editorial: Nucleic Acid-Associated Inflammation.

Laguette N, Langevin C, Olagnier D, Torraca V, Vanpouille-Box C, Verrier ER.

Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes.

Taffoni C, Steer A, Marines J, Chamma H, Vila IK, Laguette N

more

Animal Models for the Study of Nucleic Acid Immunity: Novel Tools and New Perspectives

Isabelle K Vila , Maxence Fretaud , Dimitrios Vlachakis, Nadine Laguette, Christelle Langevin

more

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

J. Guerra, A.-L. Valadao, D. Vlachakis, K. Polak, I. K. Vila, C. Taffoni, T. Prabakaran, A. S. Marriott, R. Kaczmarek, A. Houel, B. Auzemery,S. Déjardin,P. Boudinot, B. Nawrot, N. J. Jones, S. R. Paludan, S. Kossida, C. Langevin and N. Laguette

more

V1b vasopressin receptor trafficking and signaling: Role of arrestins, G proteins and Src kinase.

Perkovska S, Méjean C, Ayoub MA, Li J, Hemery F, Corbani M, Laguette N, Ventura MA, Orcel H, Durroux T, Mouillac B, Mendre C

Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production

Bregnard, C, Guerra, J, Dejardin, S, Passalacqua, F, Benkirane, M, Laguette, N

+ Laboratory of Molecular Virology

DNA damage repair machinery and HIV escape from innate immune sensing

Brégnard C, Benkirane M, Laguette N.

+ Laboratory of Molecular Virology

Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing

Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Sobhian, B., Benkirane, M.


+ Laboratory of Molecular Virology

+ Genetic Instability and Cancer

BREGNARD Christelle
BREGNARD Christelle
Dustscher
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GUERRA Jessica
GUERRA Jessica
Chercheur - IRB, Suisse
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CAVAL Vincent
CAVAL Vincent
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PASSALACQUA Franck
PASSALACQUA Franck
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ROUX Vincent
ROUX Vincent
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BENHADID Imad
BENHADID Imad
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EL MANSSOURI Hanane
EL MANSSOURI Hanane
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BALCON Lise
BALCON Lise
ONIRIS
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VALADAO Ana-Luiza
VALADAO Ana-Luiza
IRIM
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POLAK Katarzyna
POLAK Katarzyna
Chargée de Projet - CILOA
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AUZEMERY Baptiste
AUZEMERY Baptiste
Genoscreen
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MARINES Johanna
MARINES Johanna
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ADJALI Ines
ADJALI Ines
Attachée de recherche clinique - Institut Claudius Regaud, Paris
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SEDDA Alexis
SEDDA Alexis
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SACCAS Mathilde
SACCAS Mathilde
TOLLYS
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AIT-MOUFFOK Amel
AIT-MOUFFOK Amel
LinkedIn
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Supervisor: Hanane CHAMMA
Title: Identification of new regulators of immunity to pathological nucleic acids
Direction : Dr. Nadine Laguette
Date of defense: December 2022
Members of the defense jury : not yet defined


Supervisor: Soumyabrata Guha
Title : Communication entre heterochromatine et inflammation
Direction : Dr. Nadine Laguette
Since the 01-10-2021

Lab phd theses