Regulation of innate immunity by Nrf2
van der Horst D, Carter-Timofte ME, van Grevenynghe J, Laguette N, Dinkova-Kostova AT, Olagnier D
Molecular Basis of Inflammation
Molecular bases of human diseases
Inflammation is a normal reaction of the immune system in response to infections or tissue damage. It plays a pivotal role in triggering adaptive immune responses. However, unresolved inflammation is pervasive and fosters several etiologically distinct human pathologies that present with a broad range of symptoms. Such pathologies include cancer, auto-inflammatory and auto-immune disorders, but also metabolic diseases.
The Molecular Basis of Inflammation team studies the molecular mechanisms involved in the initiation, maintenance, and resolution of inflammation. To decipher how deregulation of these processes promote pathologies, we study inflammatory responses at several scales:
- At the molecular level: we identify and characterize new pathways involved in triggering inflammatory pathologies,
- At the cellular level: we characterize how these pathways are regulated depending on cellular identity,
- At the tissue level: we study how cellular heterogeneity within tissues dictates the outcome of inflammatory response and impacts homeostasis
- At the organism level: we study inflammatory responses and the consequences of their pathological activation on integrated in vivo models .
To achieve these aims, the Molecular Basis of Inflammation team uses and develops techniques ranging from nanotechnologies, single-cell transcriptomics, to in vivo phenotyping. We develop interdisciplinary approaches around these themes through networks and collaborations at national (https://www.innasco.fr/) and international (https://frontinov.cnrs.fr/) levels.
The “Molecular Basis of Inflammation” team welcomes applications from research scientists and engineers willing to implement new technologies in a fast-evolving area of research.
Contact: Nadine.Laguette@igh.cnrs.fr
PUBLICATIONS OF THE TEAM
Alternative pathways driven by STING: From innate Immunity to lipid metabolism.
Vila IK, Guha S, Kalucka J, Olagnier D, Laguette N.
The crosstalk between DNA-PK and cGAS drives tumor immunogenicity
Clara Taffoni, Johanna Marines, Hanane Chamma, Mathilde Saccas, Amel Bouzid, Soumyabrata Guha, Ana-Luiza Chaves Valadao, Katarzyna Polak, Maguy Del Rio, Celine Gongora, Donovan Pineau, Jean-Philippe Hugnot, Karima Kissa, Laura Fontenille, Fabien P. Blanchet, Isabelle K. Vila, Nadine Laguette
Protocol to induce and assess cGAS-STING pathway activation in vitro.
Chamma H, Guha S, Laguette N, Vila IK
Activation of STING in the pancreatic tumor microenvironment: A novel therapeutic opportunity
Hanane Chamma, Isabelle K Vila, Clara Taffoni, Andrei Turtoi, Nadine Laguette
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
Isabelle K.Vila, Hanane Chamma, Alizée Steer, Mathilde Saccas, Clara Taffoni, Evgenia Turtoi, Line S.Reinert, Saqib Hussain, Johanna Marines, Lei Jin, Xavier Bonnefont, Mathieu Hubert, Olivier Schwartz, Soren R.Paludan, Gaetan Van Simaeys, Gilles Doumont, Bijan Sobhian, Dimitrios Vlachakis, Andrei Turtoi, Nadine Laguette
Editorial: Nucleic Acid-Associated Inflammation.
Laguette N, Langevin C, Olagnier D, Torraca V, Vanpouille-Box C, Verrier ER.
Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes.
Taffoni C, Steer A, Marines J, Chamma H, Vila IK, Laguette N
Animal Models for the Study of Nucleic Acid Immunity: Novel Tools and New Perspectives
Isabelle K Vila , Maxence Fretaud , Dimitrios Vlachakis, Nadine Laguette, Christelle Langevin
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation
J. Guerra, A.-L. Valadao, D. Vlachakis, K. Polak, I. K. Vila, C. Taffoni, T. Prabakaran, A. S. Marriott, R. Kaczmarek, A. Houel, B. Auzemery,S. Déjardin,P. Boudinot, B. Nawrot, N. J. Jones, S. R. Paludan, S. Kossida, C. Langevin and N. Laguette
V1b vasopressin receptor trafficking and signaling: Role of arrestins, G proteins and Src kinase.
Perkovska S, Méjean C, Ayoub MA, Li J, Hemery F, Corbani M, Laguette N, Ventura MA, Orcel H, Durroux T, Mouillac B, Mendre C
Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production
Bregnard, C, Guerra, J, Dejardin, S, Passalacqua, F, Benkirane, M, Laguette, N
Shaping of the host cell by viral accessory proteins
Laguette N, Benkirane M.
DNA damage repair machinery and HIV escape from innate immune sensing
Brégnard C, Benkirane M, Laguette N.
Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing
Laguette,N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., Kirchhoff, F., Constantinou, A., Sobhian, B., Benkirane, M.
Supervisor: Hanane CHAMMA
Title: Identification of new regulators of immunity to pathological nucleic acids
Direction : Dr. Nadine Laguette
Date of defense: December 2022
Members of the defense jury : not yet defined
Supervisor: Soumyabrata Guha
Title : Communication entre heterochromatine et inflammation
Direction : Dr. Nadine Laguette
Since the 01-10-2021
